Search Results - "HARMS, John F"

Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways by Padovan-Neto, Fernando E, Sammut, Stephen, Chakroborty, Shreaya, Dec, Alexander M, Threlfell, Sarah, Campbell, Peter W, Mudrakola, Vishnu, Harms, John F, Schmidt, Christopher J, West, Anthony R

“…The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a critical role in the regulation of cAMP and cGMP signaling…”
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Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis by Siuciak, Judith A., Chapin, Douglas S., Harms, John F., Lebel, Lorraine A., McCarthy, Sheryl A., Chambers, Leslie, Shrikhande, Alka, Wong, Stephen, Menniti, Frank S., Schmidt, Christopher J.

“…Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase expressed primarily in dopaminoreceptive medium spiny neurons of…”
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Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease by Kleiman, Robin J, Kimmel, Lida H, Bove, Susan E, Lanz, Thomas A, Harms, John F, Romegialli, Alison, Miller, Kenneth S, Willis, Amy, des Etages, Shelley, Kuhn, Max, Schmidt, Christopher J

“…Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced…”
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CCK Receptor Inhibition Reduces Pancreatic Tumor Fibrosis and Promotes Nanoparticle Delivery by Abraham, Thomas, Armold, Michael, McGovern, Christopher, Harms, John F, Darok, Matthew C, Gigliotti, Christopher, Adair, Bernadette, Gray, Jennifer L, Kelly, Deborah F, Adair, James H, Matters, Gail L

“…The poor prognosis for pancreatic ductal adenocarcinoma (PDAC) patients is due in part to the highly fibrotic nature of the tumors that impedes delivery of…”
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Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer by Matters, Gail L, Harms, John F

“…It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40%…”
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Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide by Harms, John F, Menniti, Frank S, Schmidt, Christopher J

“…PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive…”
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Kinetics of Metastatic Breast Cancer Cell Trafficking in Bone by PHADKE, Pushkar A, MERCER, Robyn R, GAY, Carol V, MASTRO, Andrea M, WELCH, Danny R, HARMS, John F, YUJIANG JIA, FROST, Andra R, JEWELL, Jennifer L, BUSSARD, Karen M, NELSON, Shakira, MOORE, Cynthia, KAPPES, John C

“…Purpose: In vivo studies have focused on the latter stages of the bone metastatic process (osteolysis), whereas little is known about earlier events, e.g.,…”
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Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background by Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Martin, Ashley N., Harms, John F., Schmidt, Christopher J.

“…The phenotype of genetically modified animals is strongly influenced by both the genetic background of the animal as well as environmental factors. We have…”
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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models by Beaumont, Vahri, Zhong, Sheng, Lin, Hai, Xu, WenJin, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Wadel, Kristian, Buisson, Bruno, Padovan-Neto, Fernando E., Chakroborty, Shreaya, Ward, Karen M., Harms, John F., Beltran, Jose, Kwan, Mei, Ghavami, Afshin, Häggkvist, Jenny, Tóth, Miklós, Halldin, Christer, Varrone, Andrea, Schaab, Christoph, Dybowski, J. Nikolaj, Elschenbroich, Sarah, Lehtimäki, Kimmo, Heikkinen, Taneli, Park, Larry, Rosinski, James, Mrzljak, Ladislav, Lavery, Daniel, West, Anthony R., Schmidt, Christopher J., Zaleska, Margaret M., Munoz-Sanjuan, Ignacio

“…Huntington’s disease (HD) symptoms are driven to a large extent by dysfunction of the basal ganglia circuitry. HD patients exhibit reduced striatal…”
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Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia by VERHOEST, Patrick R, CHAPIN, Douglas S, PANDIT, Jayvardhan, PROULX-LAFRANCE, Caroline, SCHMIDT, Anne W, SCHMIDT, Christopher J, SUICIAK, Judith A, LIRAS, Spiros, CORMAN, Michael, FONSECA, Kari, HARMS, John F, XINJUN HOU, MARR, Eric S, MENNITI, Frank S, NELSON, Frederick, O'CONNOR, Rebecca

“…By utilizing structure-based drug design (SBDD) knowledge, a novel class of phosphodiesterase (PDE) 10A inhibitors was identified. The structure-based drug…”
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Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia † Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1) by Verhoest, Patrick R, Chapin, Douglas S, Corman, Michael, Fonseca, Kari, Harms, John F, Hou, Xinjun, Marr, Eric S, Menniti, Frank S, Nelson, Frederick, O’Connor, Rebecca, Pandit, Jayvardhan, Proulx-LaFrance, Caroline, Schmidt, Anne W, Schmidt, Christopher J, Suiciak, Judith A, Liras, Spiros

“…By utilizing structure-based drug design (SBDD) knowledge, a novel class of phosphodiesterase (PDE) 10A inhibitors was identified. The structure-based drug…”
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Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate by Helal, Christopher J, Arnold, Eric, Boyden, Tracey, Chang, Cheng, Chappie, Thomas A, Fisher, Ethan, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Pandit, Jayvardhan, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, McGinnis, Dina, O’Connor, Rebecca E, O’Donnell, Christopher J, Ogden, Adam, Piotrowski, Mary, Schmidt, Christopher J, Seymour, Patricia A, Ueno, Hirokazu, Vansell, Nichole, Verhoest, Patrick R, Yang, Edward X

“…Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core…”
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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor by Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X

“…Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the…”
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Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo by Kleiman, Robin J, Chapin, Douglas S, Christoffersen, Curt, Freeman, Jody, Fonseca, Kari R, Geoghegan, Kieran F, Grimwood, Sarah, Guanowsky, Victor, Hajós, Mihály, Harms, John F, Helal, Christopher J, Hoffmann, William E, Kocan, Geralyn P, Majchrzak, Mark J, McGinnis, Dina, McLean, Stafford, Menniti, Frank S, Nelson, Fredrick, Roof, Robin, Schmidt, Anne W, Seymour, Patricia A, Stephenson, Diane T, Tingley, Francis David, Vanase-Frawley, Michelle, Verhoest, Patrick R, Schmidt, Christopher J

“…Cyclic nucleotides are critical regulators of synaptic plasticity and participate in requisite signaling cascades implicated across multiple neurotransmitter…”
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Maintaining GFP tissue fluorescence through bone decalcification and long-term storage by Harms, John F, Budgeon, Lynn R, Christensen, Neil D, Welch, Danny R

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Tu1923 A Single Nucleotide Polymorphism of the CCK-B Receptor Does Not Effect Survival in Colon & Gastric Cancer by Alsubai, Jelal, Smith, Jill P, McGovern, Christopher, Matters, Gail, Harms, John F, Liao, Jiangang

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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor by Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, LaChapelle, Erik A, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X

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Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters Substance P level by Erin, Nuray, Akdas Barkan, Güliz, Harms, John F., Clawson, Gary A.

“…We have previously demonstrated that inactivation of capsaicin-sensitive sensory neurons enhances lung and heart metastases of breast carcinoma. Because a…”
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Role of endogenous cholecystokinin on growth of human pancreatic cancer by MATTERS, Gail L, MCGOVERN, Christopher, HARMS, John F, MARKOVIC, Kevin, ANSON, Krystal, JAYAKUMAR, Calpurnia, MARTENIS, Melissa, AWAD, Christina, SMITH, Jill P

“…Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer. Although down-regulation of gastrin inhibits growth of pancreatic cancer, the…”
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Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasis by KOBLINSKI, Jennifer E, KAPLAN-SINGER, Benjamin R, WELCH, Danny R, KLEINMAN, Hynda K, VANOSDOL, Sherilyn J, WU, Michael, ENGBRING, Jean A, SONGLIN WANG, GOLDSMITH, Corinne M, PIPER, John T, VOSTAL, Jaroslav G, HARMS, John F

“…Skeletal metastases occur with high incidence in patients with breast cancer and cause long-term skeletal morbidity. Osteonectin (SPARC, BM-40) is a bone…”
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