Search Results - "HARLEY, J. B."

The PTPN22 C1858T functional polymorphism and autoimmune diseases-a meta-analysis by Lee, Y. H., Rho, Y. H., Choi, S. J., Ji, J. D., Song, G. G., Nath, S. K., Harley, J. B.

“…Objective. To assess whether combined evidence shows the association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) C1858T polymorphism and…”
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Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network by Bush, WS, Crosslin, DR, Owusu-Obeng, A, Wallace, J, Almoguera, B, Basford, MA, Bielinski, SJ, Carrell, DS, Connolly, JJ, Crawford, D, Doheny, KF, Gallego, CJ, Gordon, AS, Keating, B, Kirby, J, Kitchner, T, Manzi, S, Mejia, AR, Pan, V, Perry, CL, Peterson, JF, Prows, CA, Ralston, J, Scott, SA, Scrol, A, Smith, M, Stallings, SC, Veldhuizen, T, Wolf, W, Volpi, S, Wiley, K, Li, R, Manolio, T, Bottinger, E, Brilliant, MH, Carey, D, Chisholm, RL, Chute, CG, Haines, JL, Hakonarson, H, Harley, JB, Holm, IA, Kullo, IJ, Jarvik, GP, Larson, EB, McCarty, CA, Williams, MS, Denny, JC, Rasmussen-Torvik, LJ, Roden, DM, Ritchie, MD

“…Genetic variation can affect drug response in multiple ways, although it remains unclear how rare genetic variants affect drug response. The electronic Medical…”
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Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus by Sawalha, A H, Kaufman, K M, Kelly, J A, Adler, A J, Aberle, T, Kilpatrick, J, Wakeland, E K, Li, Q-Z, Wandstrat, A E, Karp, D R, James, J A, Merrill, J T, Lipsky, P, Harley, J B

“…The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of…”
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High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus by Niewold, T B, Hua, J, Lehman, T J A, Harley, J B, Crow, M K

“…Interferon alpha (IFN-alpha) levels are elevated in many patients with systemic lupus erythematosus (SLE); however it is not known whether high serum IFN-alpha…”
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Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort by Namjou, B, Kothari, P H, Kelly, J A, Glenn, S B, Ojwang, J O, Adler, A, Alarcón-Riquelme, M E, Gallant, C J, Boackle, S A, Criswell, L A, Kimberly, R P, Brown, E, Edberg, J, Stevens, A M, Jacob, C O, Tsao, B P, Gilkeson, G S, Kamen, D L, Merrill, J T, Petri, M, Goldman, R R, Vila, L M, Anaya, J-M, Niewold, T B, Martin, J, Pons-Estel, B A, Sabio, J M, Callejas, J L, Vyse, T J, Bae, S-C, Perrino, F W, Freedman, B I, Scofield, R H, Moser, K L, Gaffney, P M, James, J A, Langefeld, C D, Kaufman, K M, Harley, J B, Atkinson, J P

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with a complex pathogenesis in which genetic, hormonal and environmental factors have a…”
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MHC associations with clinical and autoantibody manifestations in European SLE by Morris, D L, Fernando, M M A, Taylor, K E, Chung, S A, Nititham, J, Alarcón-Riquelme, M E, Barcellos, L F, Behrens, T W, Cotsapas, C, Gaffney, P M, Graham, R R, Pons-Estel, B A, Gregersen, P K, Harley, J B, Hauser, S L, Hom, G, Langefeld, C D, Noble, J A, Rioux, J D, Seldin, M F, Vyse, T J, Criswell, L A

“…Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to…”
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Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus by James, JA, Kim-Howard, XR, Bruner, BF, Jonsson, MK, McClain, MT, Arbuckle, MR, Walker, C., Dennis, GJ, Merrill, JT, Harley, JB

“…Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow,…”
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The curiously suspicious: a role for Epstein-Barr virus in lupus by Harley, J B, Harley, I T W, Guthridge, J M, James, J A

“…While the events initiating the development of autoantibodies in systemic lupus erythematosus (SLE) have not yet been convincingly established, newly developed…”
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Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis by Lin, C P, Adrianto, I, Lessard, C J, Kelly, J A, Kaufman, K M, Guthridge, J M, Freedman, B I, Anaya, J-M, Alarcón-Riquelme, M E, Pons-Estel, B A, Martin, J, Glenn, S, Adler, A, Bae, S-C, Park, S-Y, Bang, S-Y, Song, Y-W, Boackle, S A, Brown, E E, Edberg, J C, Alarcón, G S, Petri, M A, Criswell, L A, Ramsey-Goldman, R, Reveille, J D, Vila, L M, Gilkeson, G S, Kamen, D L, Ziegler, J, Jacob, C O, Rasmussen, A, James, J A, Kimberly, R P, Merrill, J T, Niewold, T B, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Moser, K L, Harley, J B, Gaffney, P M, Montgomery, C G

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of…”
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A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus by Wang, S, Adrianto, I, Wiley, G B, Lessard, C J, Kelly, J A, Adler, A J, Glenn, S B, Williams, A H, Ziegler, J T, Comeau, M E, Marion, M C, Wakeland, B E, Liang, C, Kaufman, K M, Guthridge, J M, Alarcón-Riquelme, M E, Alarcón, G S, Anaya, J-M, Bae, S-C, Kim, J-H, Joo, Y B, Boackle, S A, Brown, E E, Petri, M A, Ramsey-Goldman, R, Reveille, J D, Vilá, L M, Criswell, L A, Edberg, J C, Freedman, B I, Gilkeson, G S, Jacob, C O, James, J A, Kamen, D L, Kimberly, R P, Martin, J, Merrill, J T, Niewold, T B, Pons-Estel, B A, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Harley, J B, Wakeland, E K, Moser, K L, Montgomery, C G, Gaffney, P M

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies…”
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Genetic associations of LYN with systemic lupus erythematosus by Lu, R, Vidal, G S, Kelly, J A, Delgado-Vega, A M, Howard, X K, Macwana, S R, Dominguez, N, Klein, W, Burrell, C, Harley, I T, Kaufman, K M, Bruner, G R, Moser, K L, Gaffney, P M, Gilkeson, G S, Wakeland, E K, Li, Q-Z, Langefeld, C D, Marion, M C, Divers, J, Alarcón, G S, Brown, E E, Kimberly, R P, Edberg, J C, Ramsey-Goldman, R, Reveille, J D, McGwin Jr, G, Vilá, L M, Petri, M A, Bae, S-C, Cho, S-K, Bang, S-Y, Kim, I, Choi, C-B, Martin, J, Vyse, T J, Merrill, J T, Harley, J B, Alarcón-Riquelme, M E, Nath, S K, James, J A, Guthridge, J M

“…We targeted LYN, a src-tyosine kinase involved in B-cell activation, in case–control association studies using populations of European-American,…”
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Smoking is not associated with autoantibody production in systemic lupus erythematosus patients, unaffected first-degree relatives, nor healthy controls by Young, KA, Terrell, DR, Guthridge, JM, Kamen, DL, Gilkeson, GS, Karp, DR, Ishimori, ML, Weisman, MH, Holers, VM, Harley, JB, Norris, JM, James, JA

“…Objective The objective of this paper is to examine whether smoking is associated with autoantibody production in systemic lupus erythematosus (SLE) patients,…”
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Genome Scan of Human Systemic Lupus Erythematosus by Regression Modeling: Evidence of Linkage and Epistasis at 4p16-15.2 by Gray-McGuire, C., Moser, K.L., Gaffney, P.M., Kelly, J., Yu, H., Olson, J.M., Jedrey, C.M., Jacobs, K.B., Kimberly, R.P., Neas, B.R., Rich, S.S., Behrens, T.W., Harley, J.B.

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving at least hormonal, environmental, and genetic factors. Familial aggregation, a…”
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Anti-neutrophil cytoplasmic antibodies target sequential functional proteinase 3 epitopes in the sera of patients with Wegener's granulomatosis by Bruner, B.F, Vista, E.S, Wynn, D.M, Harley, J.B, James, J.A

“…Many patients with Wegener's granulomatosis (WG) have anti-neutrophil cytoplasmic antibodies (c-ANCA). Aside from being a diagnostic marker, these…”
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An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus by James, J A, Kaufman, K M, Farris, A D, Taylor-Albert, E, Lehman, T J, Harley, J B

“…An unknown environmental agent has been suspected to induce systemic lupus erythematosus (lupus) in man. Prompted by our recent immunochemical findings, we…”
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The genetics of systemic lupus erythematosus: putting the pieces together by Kelly, J A, Moser, K L, Harley, J B

“…With lambda(s) estimates of 10 to 20 and other evidence of familial aggregation, as well as a monozygotic twin concordance rate >20, systemic lupus…”
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Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multicenter Pilot for Preemptive Pharmacogenomics in Electronic Health Record Systems by Rasmussen-Torvik, L J, Stallings, S C, Gordon, A S, Almoguera, B, Basford, M A, Bielinski, S J, Brautbar, A, Brilliant, M H, Carrell, D S, Connolly, J J, Crosslin, D R, Doheny, K F, Gallego, C J, Gottesman, O, Kim, D S, Leppig, K A, Li, R, Lin, S, Manzi, S, Mejia, A R, Pacheco, J A, Pan, V, Pathak, J, Perry, C L, Peterson, J F, Prows, C A, Ralston, J, Rasmussen, L V, Ritchie, M D, Sadhasivam, S, Scott, S A, Smith, M, Vega, A, Vinks, A A, Volpi, S, Wolf, W A, Bottinger, E, Chisholm, R L, Chute, C G, Haines, J L, Harley, J B, Keating, B, Holm, I A, Kullo, I J, Jarvik, G P, Larson, E B, Manolio, T, McCarty, C A, Nickerson, D A, Scherer, S E, Williams, M S, Roden, D M, Denny, J C

“…We describe here the design and initial implementation of the eMERGE‐PGx project. eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics…”
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Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus by Ramos, P S, Kelly, J A, Gray-McGuire, C, Bruner, G R, Leiran, A N, Meyer, C M, Namjou, B, Espe, K J, Ortmann, W A, Reichlin, M, Langefeld, C D, James, J A, Gaffney, P M, Behrens, T W, Harley, J B, Moser, K L

“…Autoantibodies are clinically relevant biomarkers for numerous autoimmune disorders. The genetic basis of autoantibody production in systemic lupus…”
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Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective by Jeffries, M, Hamadeh, F, Aberle, T, Glenn, S, Kamen, DL, Kelly, JA, Reichlin, M, Harley, JB, Sawalha, AH

“…Systemic lupus erythematosus is a chronic autoimmune disease that can be associated with a variety of haematological manifestations. We identified 76 patients…”
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Recent insights into the genetic basis of systemic lupus erythematosus by Moser, K L, Kelly, J A, Lessard, C J, Harley, J B

“…Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or lupus) in the 1970s with associations in the human leukocyte antigen…”
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