Search Results - "HARKEN, A. H"

Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium : Two paradoxes revisited by CLEVELAND, J. C, MELDRUM, D. R, CAIN, B. S, BANERJEE, A, HARKEN, A. H

“…Patients receiving oral hypoglycemic agents for diabetes mellitus are at increased risk of cardiovascular mortality. Oral hypoglycemic agents are inhibitors of…”
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Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C by Mitchell, Max B, Meng, Xianzhong, Ao, Lihua, Brown, James M, Harken, Alden H, Banerjee, Anirban

“…Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against…”
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A Novel Model of Ischemia in Renal Tubular Cells Which Closely Parallels in Vivo Injury by Meldrum, K.K., Meldrum, D.R., Hile, K.L., Burnett, A.L., Harken, A.H.

“…Purpose. Renal ischemia-reperfusion (IR) injury is a devastating clinical problem. While effective animal models have been developed to investigate this…”
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Preconditioning against myocardial dysfunction after ischemia and reperfusion by an alpha 1-adrenergic mechanism by Banerjee, A, Locke-Winter, C, Rogers, K B, Mitchell, M B, Brew, E C, Cairns, C B, Bensard, D D, Harken, A H

“…Preconditioning may find ready applicability in humans facing scheduled global cardiac ischemia-reperfusion (IR) during bypass or transplantation, where such a…”
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Endotoxin induces cardiac HSP70 and resistance to endotoxemic myocardial depression in rats by Meng, X, Brown, J M, Ao, L, Nordeen, S K, Franklin, W, Harken, A H, Banerjee, A

“…Endotoxin (bacterial lipopolysaccharide, LPS) depresses myocardial function. However, heat shock and sublethal LPS can confer cardiac resistance to…”
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Role of bradykinin in cardiac functional protection after global ischemia-reperfusion in rat heart by Brew, E C, Mitchell, M B, Rehring, T F, Gamboni-Robertson, F, McIntyre, Jr, R C, Harken, A H, Banerjee, A

“…We have reported that cardiac preconditioning against ischemia-reperfusion (IR) can be induced by transient ischemia (TI) and alpha 1-adrenoreceptor…”
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Early and delayed preconditioning: differential mechanisms and additive protection by Meldrum, D R, Cleveland, Jr, J C, Rowland, R T, Banerjee, A, Harken, A H, Meng, X

“…The purposes of this study were to determine whether 1) 24-h endotoxin (ETX) pretreatment induces delayed ("second window") myocardial protection against…”
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Endotoxin Pretreatment Increases Endogenous Myocardial Catalase Activity and Decreases Ischemia-Reperfusion Injury of Isolated Rat Hearts by Brown, James M., Grosso, Michael A., Terada, Lance S., Glenn J. R. Whitman, Banerjee, Anirban, White, Carl W., Harken, Alden H., Repine, John E.

“…Hearts isolated from rats pretreated 24 hr before with endotoxin had increased myocardial catalase activity, but the same superoxide dismutase, glutathione…”
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Human SERCA2a levels correlate inversely with age in senescent human myocardium by Cain, Brian S, Meldrum, Daniel R, Joo, Kyung S, Wang, Ju-Feng, Meng, Xianzhong, Cleveland, Joseph C, Banerjee, Anirban, Harken, Alden H

“…Objectives. This study sought to characterize functional impairment after simulated ischemia-reperfusion (I/R) or Ca2+bolus in senescent human myocardium and…”
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Cardiac preconditioning with calcium: Clinically accessible myocardial protection by Meldrum, Daniel R., Cleveland, Joseph C., Sheridan, Brett C., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…Cardiac preconditioning is mediated by protein kinase C. Although endogenous calcium is a potent stimulus of protein kinase C, it remains unknown whether…”
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Ischemic preconditioning in human and rat ventricle by Cleveland, Jr, J C, Wollmering, M M, Meldrum, D R, Rowland, R T, Rehring, T F, Sheridan, B C, Harken, A H, Banerjee, A

“…The signal transduction of ischemic preconditioning involves activation of endogenous receptor-based systems, including alpha 1-adrenoceptors and adenosine…”
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p38 MAPK Inhibition Decreases TNF-α Production and Enhances Postischemic Human Myocardial Function by Cain, Brian S., Meldrum, Daniel R., Meng, Xianzhong, Dinarello, Charles A., Shames, Brian D., Banerjee, Anirban, Harken, Alden H.

“…Introduction.TNF-α is a proinflammatory cytokine implicated in myocardial dysfunction following ischemia/reperfusion (I/R). I/R results in myocardial…”
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Dysfunction of cGMP-mediated pulmonary vasorelaxation in endotoxin-induced acute lung injury by Fullerton, D A, McIntyre, Jr, R C, Hahn, A R, Agrafojo, J, Koike, K, Meng, X, Banerjee, A, Harken, A H

“…Endothelial-dependent and -independent cGMP-mediated mechanisms of pulmonary vasorelaxation were studied in endotoxin-induced acute lung injury in the rat…”
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Differential cellular immunolocalization of renal tumour necrosis factor‐α production during ischaemia versus endotoxaemia by Donnahoo, K. K., Meng, X., Ao, L., Ayala, A., Shames, B. D., Cain, M. P., Harken, A. H., Meldrum, D. R.

“…Summary Both renal ischaemia and endotoxaemia provoke renal dysfunction and cellular injury. Although the clinical manifestation of each insult is similar…”
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Protein kinase C mediates Ca2(+)-induced cardioadaptation to ischemia-reperfusion injury by Meldrum, D R, Cleveland, Jr, J C, Mitchell, M B, Sheridan, B C, Gamboni-Robertson, F, Harken, A H, Banerjee, A

“…Although protein kinase C (PKC)-mediated cardioadaptation to ischemia-reperfusion (IR) is accompanied by increased intracellular Ca2+ concentration, it is…”
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Interleukin 1 Pretreatment Decreases Ischemia/Reperfusion Injury by Brown, James M., White, Carl W., Terada, Lance S., Grosso, Michael A., Shanley, Paul F., Mulvin, David W., Banerjee, Anirban, Glenn J. R. Whitman, Harken, Alden H., Repine, John E.

“…Hearts isolated from rats treated 36 hr before with interleukin 1 (IL-1) had increased glucose-6-phosphate dehydrogenase (G6PD) activity and decreased hydrogen…”
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Adenosine Reduces Cardiac TNF-α Production and Human Myocardial Injury Following Ischemia-Reperfusion by Cain, Brian S., Meldrum, Daniel R., Dinarello, Charles A., Meng, Xianzhong, Banerjee, Anirban, Harken, Alden H.

“…Myocardial tumor necrosis factor-α (TNF-α) is an autocrine contributor to myocardial dysfunction and cardiomyocyte death in ischemia-reperfusion injury (I/R),…”
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Adaptive and maladaptive mechanisms of cellular priming by MELDRUM, D. R, CLEVELAND, J. C, MOORE, E. E, PARTRICK, D. A, BANERJEE, A, HARKEN, A. H

“…The mechanisms of cellular priming resulting in both adaptive and maladaptive responses to subsequent injury and strategies for manipulating this priming to…”
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Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts by BROWN, J. M, TERADA, L. S, GROSSO, M. A, WHITMANN, G. J, VELASCO, S. E, PATT, A, HARKEN, A. H, REPINE, J. E

“…Three lines of investigation indicated that hydrogen peroxide (H2O2) from xanthine oxidase (XO) contributes to cardiac dysfunction during reperfusion after…”
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LPS-induced delayed myocardial adaptation enhances acute preconditioning to optimize postischemic cardiac function by Rowland, R T, Meng, X, Cleveland, Jr, J C, Meldrum, D R, Harken, A H, Brown, J M

“…Myocardial tolerance to ischemia and reperfusion (I/R) injury can be achieved by either acute or delayed cardioprotective mechanisms. Ischemic preconditioning…”
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