Search Results - "HARDY, Serge"

Physiological and oncogenic roles of the PRL phosphatases by Hardy, Serge, Kostantin, Elie, Hatzihristidis, Teri, Zolotarov, Yevgen, Uetani, Noriko, Tremblay, Michel L.

“…The human Phosphatase of Regenerative Liver (PRL) family comprises three members (PRL‐1, ‐2, ‐3; gene name PTP4A1, PTP4A2, PTP4A3) that are highly expressed in…”
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Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism by Hardy, Serge, Kostantin, Elie, Wang, Shan Jin, Hristova, Tzvetena, Galicia-Vázquez, Gabriela, Baranov, Pavel V., Pelletier, Jerry, Tremblay, Michel L.

“…Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association…”
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Modeling ocular lens disease in Xenopus by Viet, Justine, Reboutier, David, Hardy, Serge, Lachke, Salil A., Paillard, Luc, Gautier‐Courteille, Carole

“…Background Ocular lens clouding is termed as cataract, which depending on the onset, is classified as congenital or age‐related. Developing new cataract…”
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Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth by Kostantin, Elie, Hardy, Serge, Valinsky, William C., Kompatscher, Andreas, de Baaij, Jeroen H.F., Zolotarov, Yevgen, Landry, Melissa, Uetani, Noriko, Martínez-Cruz, Luis Alfonso, Hoenderop, Joost G.J., Shrier, Alvin, Tremblay, Michel L.

“…The oncogenic phosphatase of regenerating liver 2 (PRL-2) has been shown to regulate intracellular magnesium levels by forming a complex through an extended…”
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Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain by Wu, Chia-Lun, Hardy, Serge, Aubry, Isabelle, Landry, Melissa, Haggarty, Allison, Saragovi, Horacio Uri, Tremblay, Michel L

“…Receptor tyrosine phosphatase sigma (RPTPσ) plays an important role in the regulation of axonal outgrowth and neural regeneration. Recent studies have…”
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Reverse genetics in eukaryotes by Hardy, Serge, Legagneux, Vincent, Audic, Yann, Paillard, Luc

“…Reverse genetics consists in the modification of the activity of a target gene to analyse the phenotypic consequences. Four main approaches are used towards…”
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Oleate Promotes the Proliferation of Breast Cancer Cells via the G Protein-coupled Receptor GPR40 by Hardy, Serge, St-Onge, Geneviève G., Joly, Érik, Langelier, Yves, Prentki, Marc

“…Evidence from epidemiological studies and animal models suggests a link between high levels of dietary fat intake and risk of breast cancer. In addition,…”
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Impact of oncogenic protein tyrosine phosphatases in cancer by Hardy, Serge, Julien, Sofi G, Tremblay, Michel L

“…Protein tyrosine phosphatases (PTPs) constitute a large family of enzymes that can exert both positive and negative effects on signaling pathways. They play…”
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Mapping of the Lipid-Binding and Stability Properties of the Central Rod Domain of Human Dystrophin by Legardinier, Sébastien, Raguénès-Nicol, Céline, Tascon, Christophe, Rocher, Chantal, Hardy, Serge, Hubert, Jean-François, Le Rumeur, Elisabeth

“…Dystrophin is a cytoskeletal protein that confers resistance to the sarcolemma against the stress of contraction–relaxation cycles by interacting with…”
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Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse by Hassan, Syed-Wajahat, Doody, Karen M, Hardy, Serge, Uetani, Noriko, Cournoyer, Denis, Tremblay, Michel L

“…T cell protein tyrosine phosphatase (TC-PTP/PTPN2) is an enzyme that is essential for the proper functioning of the immune system and that participates in the…”
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A Two-amino Acid Mutation Encountered in Duchenne Muscular Dystrophy Decreases Stability of the Rod Domain 23 (R23) Spectrin-like Repeat of Dystrophin by Legardinier, Sébastien, Legrand, Baptiste, Raguénès-Nicol, Céline, Bondon, Arnaud, Hardy, Serge, Tascon, Christophe, Le Rumeur, Elisabeth, Hubert, Jean-François

“…Lack of functional dystrophin causes severe Duchenne muscular dystrophy. The subsarcolemmal location of dystrophin, as well as its association with both…”
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Caspase-3 Regulates Catalytic Activity and Scaffolding Functions of the Protein Tyrosine Phosphatase PEST, a Novel Modulator of the Apoptotic Response by Hallé, Maxime, Liu, Ying-Chih, Hardy, Serge, Théberge, Jean-François, Blanchetot, Christophe, Bourdeau, Annie, Meng, Tzu-Ching, Tremblay, Michel L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PTB Regulates the Processing of a 3′-Terminal Exon by Repressing both Splicing and Polyadenylation by Le Sommer, Caroline, Lesimple, Michelle, Mereau, Agnès, Menoret, Severine, Allo, Marie-Rose, Hardy, Serge

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inside the human cancer tyrosine phosphatome by Tremblay, Michel L, Julien, Sofi G, Dubé, Nadia, Hardy, Serge

“…Key Points The protein tyrosine phosphatase (Ptp) family comprises 107 members that are classified into four classes on the basis of the amino acid sequences…”
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Protein tyrosine phosphatome metabolic screen identifies TC‐PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics by Vinette, Valerie, Aubry, Isabelle, Insull, Hayley, Uetani, Noriko, Hardy, Serge, Tremblay, Michel L.

“…Metabolic reprogramming occurs in cancer cells and is regulated partly by the opposing actions of tyrosine kinases and tyrosine phosphatases. Several members…”
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PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics by Hardy, Serge, Zolotarov, Yevgen, Coleman, Jacob, Roitman, Simon, Khursheed, Hira, Aubry, Isabelle, Uetani, Noriko, Tremblay, Michel L

“…Phosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2, PTP4A3, respectively) control intracellular magnesium levels by…”
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Saturated Fatty Acid-induced Apoptosis in MDA-MB-231 Breast Cancer Cells by Hardy, Serge, El-Assaad, Wissal, Przybytkowski, Ewa, Joly, Erik, Prentki, Marc, Langelier, Yves

“…Little is known about the biochemical basis of the action of free fatty acids (FFA) on breast cancer cell proliferation and apoptosis. Here we report that…”
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Investigating alternative RNA splicing in Xenopus by Mereau, Agnès, Hardy, Serge

“…Alternative splicing, the process by which distinct mature mRNAs can be produced from a single primary transcript, is a key mechanism to increase the organism…”
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PRL Phosphatases Promote Tumor Progression by Regulating the Level of Intracellular Magnesium by Hardy, Serge, Kostantin, Elie, Wang, Shan Jin, Uetani, Noriko, Tremblay, Michel L.

“…The Phosphatase of Regenerative Liver (PRL) enzymes (PRL‐1,‐2,‐3; gene name PTP4A1, PTP4A2, PTP4A3) are members of the protein tyrosine phosphatase family…”
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Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2 by Giménez-Mascarell, Paula, Oyenarte, Iker, Hardy, Serge, Breiderhoff, Tilman, Stuiver, Marchel, Kostantin, Elie, Diercks, Tammo, Pey, Angel L., Ereño-Orbea, June, Martínez-Chantar, María Luz, Khalaf-Nazzal, Reham, Claverie-Martin, Felix, Müller, Dominik, Tremblay, Michel L., Martínez-Cruz, Luis Alfonso

“…Phosphatases of regenerating liver (PRLs), the most oncogenic of all protein-tyrosine phosphatases (PTPs), play a critical role in metastatic progression of…”
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