Search Results - "HARDY, Richard W"

Insect Antiviral Innate Immunity: Pathways, Effectors, and Connections by Kingsolver, Megan B., Huang, Zhijing, Hardy, Richard W.

“…Insects are infected by a wide array of viruses some of which are insect restricted and pathogenic, and some of which are transmitted by biting insects to…”
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Differential viral RNA methylation contributes to pathogen blocking in Wolbachia-colonized arthropods by Bhattacharya, Tamanash, Yan, Liewei, Crawford, John M, Zaher, Hani, Newton, Irene L G, Hardy, Richard W

“…Arthropod endosymbiont Wolbachia pipientis is part of a global biocontrol strategy to reduce the replication of mosquito-borne RNA viruses such as…”
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Wolbachia elevates host methyltransferase expression to block an RNA virus early during infection by Bhattacharya, Tamanash, Newton, Irene L G, Hardy, Richard W

“…Wolbachia pipientis is an intracellular endosymbiont known to confer host resistance against RNA viruses in insects. However, the causal mechanism underlying…”
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An Antiviral Role for Antimicrobial Peptides during the Arthropod Response to Alphavirus Replication by Huang, Zhijing, Kingsolver, Megan B, Avadhanula, Vasanthi, Hardy, Richard W

“…Erratum ( vol. 87 , p. 6536 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Viral RNA is a target for Wolbachia-mediated pathogen blocking by Bhattacharya, Tamanash, Newton, Irene L G, Hardy, Richard W

“…The ability of the endosymbiont Wolbachia pipientis to restrict RNA viruses is presently being leveraged to curb global transmission of arbovirus-induced…”
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Making connections in insect innate immunity by Kingsolver, Megan B., Hardy, Richard W.

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A novel system for the launch of alphavirus RNA synthesis reveals a role for the Imd pathway in arthropod antiviral response by Avadhanula, Vasanthi, Weasner, Brandon P, Hardy, Gail G, Kumar, Justin P, Hardy, Richard W

“…Alphaviruses are RNA viruses transmitted between vertebrate hosts by arthropod vectors, primarily mosquitoes. How arthropods counteract alphaviruses or viruses…”
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Conflict in the Intracellular Lives of Endosymbionts and Viruses: A Mechanistic Look at Wolbachia-Mediated Pathogen-blocking by Lindsey, Amelia R I, Bhattacharya, Tamanash, Newton, Irene L G, Hardy, Richard W

“…At the forefront of vector control efforts are strategies that leverage host-microbe associations to reduce vectorial capacity. The most promising of these…”
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Comparative analyses of alphaviral RNA:Protein complexes reveals conserved host-pathogen interactions by Gebhart, Natasha N, Hardy, Richard W, Sokoloski, Kevin J

“…The identification of host / pathogen interactions is essential to both understanding the molecular biology of infection and developing rational intervention…”
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Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts by Rose, Patrick P, Hanna, Sheri L, Spiridigliozzi, Anna, Wannissorn, Nattha, Beiting, Daniel P, Ross, Susan R, Hardy, Richard W, Bambina, Shelly A, Heise, Mark T, Cherry, Sara

“…Alphaviruses, including several emerging human pathogens, are a large family of mosquito-borne viruses with Sindbis virus being a prototypical member of the…”
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Host-Dependent Modifications of Packaged Alphavirus Genomic RNA Influence Virus Replication in Mammalian Cells by Crawford, John M, Yan, Liewei L, Zaher, Hani, Hardy, Richard W

“…Alphaviruses must interact efficiently with two distinct host environments in order to replicate and transmit between vertebrate and mosquito hosts. Some…”
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Identification of Interactions between Sindbis Virus Capsid Protein and Cytoplasmic vRNA as Novel Virulence Determinants by Sokoloski, Kevin J, Nease, Lauren M, May, Nicholas A, Gebhart, Natasha N, Jones, Claire E, Morrison, Thomas E, Hardy, Richard W

“…Alphaviruses are arthropod-borne viruses that represent a significant threat to public health at a global level. While the formation of alphaviral nucleocapsid…”
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Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways by Lindsey, Amelia R I, Bhattacharya, Tamanash, Hardy, Richard W, Newton, Irene L G

“…is a maternally transmitted bacterium that manipulates arthropod and nematode biology in myriad ways. The strain colonizing creates sperm-egg incompatibilities…”
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Role for the Phosphatidylinositol 3-Kinase-Akt-TOR Pathway during Sindbis Virus Replication in Arthropods by Patel, Rohini K, Hardy, Richard W

“…The efficient transmission of alphaviruses requires the establishment of a persistent infection in the arthropod vector; however, the nature of the…”
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Alphavirus RNA synthesis and non-structural protein functions by Rupp, Jonathan C., Sokoloski, Kevin J., Gebhart, Natasha N., Hardy, Richard W.

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Host Derivation of Sindbis Virus Influences Mammalian Type I Interferon Response to Infection by Crawford, John M, Buechlein, Aaron M, Moline, Davis A, Rusch, Douglas B, Hardy, Richard W

“…Arboviruses are defined by their ability to replicate in both mosquito vectors and mammalian hosts. There is good evidence that arboviruses "prime" their…”
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Evidence of Adaptive Evolution in Wolbachia -Regulated Gene DNMT2 and Its Role in the Dipteran Immune Response and Pathogen Blocking by Bhattacharya, Tamanash, Rice, Danny W, Crawford, John M, Hardy, Richard W, Newton, Irene L G

“…Eukaryotic nucleic acid methyltransferase (MTase) proteins are essential mediators of epigenetic and epitranscriptomic regulation. DNMT2 belongs to a large,…”
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Catalytic Core of Alphavirus Nonstructural Protein nsP4 Possesses Terminal Adenylyltransferase Activity by TOMAR, Shailly, HARDY, Richard W, SMITH, Janet L, KUHN, Richard J

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Requirement for the Amino-Terminal Domain of Sindbis Virus nsP4 during Virus Infection by RUPP, Jonathan C, JUNDT, Natasha, HARDY, Richard W

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Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro by Rubach, Jon K, Wasik, Brian R, Rupp, Jonathan C, Kuhn, Richard J, Hardy, Richard W, Smith, Janet L

“…Abstract The Sindbis virus RNA-dependent RNA polymerase (nsP4) is responsible for the replication of the viral RNA genome. In infected cells, nsP4 is localized…”
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