Search Results - "HARDY, Medora M"

Epidermal COX-2 Induction Following Ultraviolet Irradiation: Suggested Mechanism for the Role of COX-2 Inhibition in Photoprotection by Tripp, Catherine S., Blomme, Eric A.G., Chinn, Kevin S., Hardy, Medora M., LaCelle, Peter, Pentland, Alice P.

“…The cyclooxygenase isoforms, COX-1 and COX-2, are involved in the biosynthesis of prostaglandin E2, a major prostaglandin involved in epidermal homeostasis and…”
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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis by Mnich, Stephen J., Blanner, Patrick M., Hu, Liangbiao G., Shaffer, Alexander F., Happa, Fernando A., O'Neil, Shawn, Ukairo, Okechukwu, Weiss, Dave, Welsh, Eric, Storer, Chad, Mbalaviele, Gabriel, Ichijo, Hidenori, Monahan, Joseph B., Hardy, Medora M., Eda, Hiroyuki

“…In this report, we show that apoptosis signal-regulating kinase 1 −/− (ASK1 KO) mice were resistant to inflammatory arthritis induced in the K/BxN serum…”
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Selective cyclooxygenase-2 inhibition does not alter keratinocyte wound responses in the mouse epidermis after abrasion by Hardy, Medora M, Blomme, Eric A G, Lisowski, Andrew, Chinn, Kevin S, Jones, Amy, Harmon, Janet M, Opsahl, Alan, Ornberg, Richard L, Tripp, Catherine S

“…The cyclooxygenase isoforms, COX-1 and COX-2, are the rate limiting enzymes in the biosynthesis of prostaglandin E(2), a major prostaglandin involved in…”
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Novel Insights into the Cellular Mechanisms of the Anti-inflammatory Effects of NF-κB Essential Modulator Binding Domain Peptides by Baima, Eric T., Guzova, Julia A., Mathialagan, Sumathy, Nagiec, Eva E., Hardy, Medora M., Song, Lily R., Bonar, Sheri L., Weinberg, Robin A., Selness, Shaun R., Woodard, Scott S., Chrencik, Jill, Hood, William F., Schindler, John F., Kishore, Nandini, Mbalaviele, Gabriel

“…The classical nuclear factor κB (NF-κB) signaling pathway is under the control of the IκB kinase (IKK) complex, which consists of IKK-1, IKK-2, and NF-κB…”
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CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain by Cortes-Burgos, Luz A., Zweifel, Ben S., Settle, Steven L., Pufahl, Robert A., Anderson, Gary D., Hardy, Medora M., Weir, Dana E., Hu, George, Happa, Fernando A., Stewart, Zachary, Muthian, Shanmugam, Graneto, Matthew J., Masferrer, Jaime L.

“…Zileuton, a redox and iron chelator 5-lipoxygenase (5-LOX) inhibitor and, leukotriene receptor antagonists are presently used clinically in the long term…”
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Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima by Leeuwenburgh, Christiaan, Hardy, Medora M., Hazen, Stanley L., Wagner, Peter, Oh-ishi, Shuji, Steinbrecher, Urs P., Heinecke, Jay W.

“…Oxidized low density lipoprotein (LDL) may be of central importance in triggering atherosclerosis. One potential pathway involves the production of nitric…”
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A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors by Zweifel, Ben S., Hardy, Medora M., Anderson, Gary D., Dufield, Dawn R., Pufahl, Robert A., Masferrer, Jaime L.

“…The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflammatory diseases including asthma, atherosclerosis, rheumatoid arthritis, pain,…”
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Cyclooxygenase 2‐dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants by Hardy, Medora M., Seibert, Karen, Manning, Pamela T., Currie, Mark G., Woerner, B. Mark, Edwards, Dorothy, Koki, Alane, Tripp, Catherine S.

“…Objective To examine cyclooxygenase‐2 (COX‐2) enzyme expression, its regulation by interleukin‐1β (IL‐1β), and the role of prostaglandin E2 (PGE2) in…”
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Low Density Lipoprotein Receptor-related Protein Modulates the Expression of Tissue-type Plasminogen Activator in Human Colon Fibroblasts by Hardy, Medora M., Feder, Joseph, Wolfe, Richard A., Bu, Guojun

“…Human colon fibroblasts (HCF) produce tissue-type plasminogen activator (t-PA) in culture, but after 24-48 h, t-PA ceases to accumulate in the medium. Here, we…”
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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/B×N serum-induced arthritis by MNICH, Stephen J, BLANNER, Patrick M, MBALAVIELE, Gabriel, ICHIJO, Hidenori, MONAHAN, Joseph B, HARDY, Medora M, EDA, Hiroyuki, HU, Liangbiao G, SHAFFER, Alexander F, HAPPA, Fernando A, O'NEIL, Shawn, UKAIRO, Okechukwu, WEISS, Dave, WELSH, Eric, STORER, Chad

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Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides by Baima, Eric T, Guzova, Julia A, Mathialagan, Sumathy, Nagiec, Eva E, Hardy, Medora M, Song, Lily R, Bonar, Sheri L, Weinberg, Robin A, Selness, Shaun R, Woodard, Scott S, Chrencik, Jill, Hood, William F, Schindler, John F, Kishore, Nandini, Mbalaviele, Gabriel

“…The classical nuclear factor kappaB (NF-kappaB) signaling pathway is under the control of the IkappaB kinase (IKK) complex, which consists of IKK-1, IKK-2, and…”
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Evaluation of activity of putative superoxide dismutase mimics. Direct analysis by stopped-flow kinetics by WEISS, R. H, FLICKINGER, A. G, RIVERS, W. J, HARDY, M. M, ASTON, K. W, RYAN, U. S, RILEY, D. P

“…By stopped-flow kinetic analysis, we have directly evaluated the superoxide dismutase (SOD) activity of a number of organic nitroxides and iron- and…”
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Superoxide dismutase mimetics inhibit neutrophil-mediated human aortic endothelial cell injury in vitro by HARDY, M. M, FLICKINGER, A. G, RILEY, D. P, WEISS, R. H, RYAN, U. S

“…In this study, we evaluated the ability of low molecular weight manganese-based superoxide dismutase mimetics to attenuate neutrophil-mediated oxygen radical…”
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Cyclooxygenase 2‐dependent prostaglandin E 2 modulates cartilage proteoglycan degradation in human osteoarthritis explants by Hardy, Medora M., Seibert, Karen, Manning, Pamela T., Currie, Mark G., Woerner, B. Mark, Edwards, Dorothy, Koki, Alane, Tripp, Catherine S.

“…Abstract Objective To examine cyclooxygenase‐2 (COX‐2) enzyme expression, its regulation by interleukin‐1β (IL‐1β), and the role of prostaglandin E 2 (PGE 2 )…”
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Expression of cyclooxygenase and regulation by interleukin-1β in human osteoarthritis tissues by Hardy, Medora M., Koki, Alane, Koboldt, Carol M., Edwards, Dorothy, Manning, Pamela T., Currie, Mark, Seibert, Karen

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Endogenous xanthine oxidase does not significantly contribute to vascular endothelial production of reactive oxygen species by Paler-Martínez, A, Panus, P C, Chumley, P H, Ryan, U, Hardy, M M, Freeman, B A

“…The contribution of xanthine oxidoreductase (XDH + XO) to the extracellular release of hydrogen peroxide (H2O2) and intracellular H2O2 concentration in…”
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Abnormal expression of a late gene family L1 protein in monkey cells abortively infected with adenovirus type 2 by Anderson, C W, Hardy, M M, Lewis, J B

“…The drastically reduced virus yields obtained from monkey cells abortively infected with adenovirus 2 (Ad2) have been attributed primarily to a severe decrease…”
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