Search Results - "HARDMAN, W. E"

Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects by HARDMAN, W. E, MOYER, M. P, CAMERON, I. L

“…The cancer chemotherapeutic efficacy of the topoisomerase I inhibitor, CPT-11 (irinotecan) is often limited by the induction of severe delayed diarrhoea. In…”
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Three Percent Dietary Fish Oil Concentrate Increased Efficacy of Doxorubicin Against MDA-MB 231 Breast Cancer Xenografts by HARDMAN, W. Elaine, AVULA, C. P, FERNANDES, Gabriel, CAMERON, Ivan L

“…Omega 3 polyunsaturated fatty acids (the type of fat found in fish oil) have been used to kill or slow the growth of cancer cells in culture and in animal…”
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Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis by BARNES, C. J, CAMERON, I. L, HARDMAN, W. E, LEE, M

“…Sustained use of non-steroidal anti-inflammatory drugs (NSAIDs) may prevent colorectal cancer. However, the optimal drug, period of efficacy and mechanism(s)…”
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Consumption of an omega-3 fatty acids product, INCELL AAFA , reduced side-effects of CPT-11 (irinotecan) in mice by Hardman, W E, Moyer, M P, Cameron, I L

“…INCELL AAFA, an omega-3 polyunsaturated fatty acid product containing a high concentration of long chain fatty acids, was tested for its ability to ameliorate…”
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Effects of iron supplementation and ET-18-OCH3 on MDA-MB 231 breast carcinomas in nude mice consuming a fish oil diet by HARDMAN, W. E, BARNES, C. J, KNIGHT, C. W, CAMERON, I. L

“…Lipid peroxidation products can be cytotoxic. Our objectives were (1) to use two pro-oxidants (iron and a pro-oxidative drug) to selectively increase lipid…”
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Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy by Hardman, W.Elaine, Moyer, Mary Pat, Cameron, Ivan L.

“…A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt./wt. fish oil…”
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Distribution of lymphoid nodules, aberrant crypt foci and tumours in the colon of carcinogen-treated rats by CAMERON, I. L, GARZA, J, HARDMAN, W. E

“…Sprague-Dawley rats were given eight weekly subcutaneous injections of 1,2-dimethylhydrazine (DMH) or of vehicle then were sacrificed at 1, 5 or 24 weeks after…”
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Efficacy of treatment of colon, lung and breast human carcinoma xenografts with: doxorubicin, cisplatin, irinotecan or topotecan by Hardman, W E, Moyer, M P, Cameron, I L

“…Given that human cancer xenografts tend to retain chemosensitivities similar to the cancerous tissue of origin, human carcinoma xenografts grown in nude mice…”
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Presence of well‐differentiated distal, but not poorly differentiated proximal, rat colon carcinomas is correlated with increased cell proliferation in and lengthening of colon crypts by Barnes, Christopher J., Hardman, W. Elaine, Cameron, Ivan L.

“…To determine whether colon crypt proliferative parameters were significantly altered by the stage of colon carcinogenesis or the type or location of colon…”
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Dietary supplementation with pectin and guar gum on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by Heitman, D W, Hardman, W E, Cameron, I L

“…The effect of dietary supplementation with pectin and/or guar gum on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis was studied using 120 male…”
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Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice by CARTER, J. W, LANCASTER, H. K, HARDMAN, W. E, CAMERON, I. L

“…Six-week-old male CF-1 mice were fed the AIN-76 diet, given eight weekly s.c. injections of either the colon carcinogen 1,2-dimethylhydrazine or saline, and…”
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Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas by Hardman, W E, Cameron, I L

“…Male, Sprague-Dawley rats were injected subcutaneously with the colon carcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 9.5 mg DMH base/per kg rat body…”
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Dietary fibre on cell proliferation in large bowel mucosal crypts near or away from lymphoid nodules and on mineral bioavailability by Cameron, I. L., Hardman, W. E., Heitman, D. W., Carter, J. W.

“…The effect of consumption for 24 weeks of different amounts (0%, 5% or 10% w/w) of fermentable (pectin and guar gum) or nonfermentable (cellulose and lignin)…”
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The nonfermentable dietary fiber lignin alters putative colon cancer risk factors but does not protect against DMH-induced colon cancer in rats by Cameron, Ivan L., Hardman, W. Elaine, Heitman, David W.

“…The effect of supplementation of the diet with auto-hydrolyzed lignin on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis was studied using 112 male…”
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Aspirin, but not sodium salicylate, indomethacin, or nabumetone, reversibly suppresses 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats by BARNES, C. J, HARDMAN, W. E, CAMERON, I. L, LEE, M

“…The aim of this study was to determine if selective inhibition of cyclooxygenase isozymes affects the initiation of carcinogen-induced colon cancer using…”
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Age-related changes in gastric mucosal repair and proliferative activities in rats exposed acutely to aspirin by Lee, M, Hardman, W E, Cameron, I

“…The present study was designed to determine whether there are any age-related changes in the repair of acute gastric mucosal injury induced by aspirin in…”
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Transforming growth factor alpha distribution in rectal crypts as a biomarker of decreased colon cancer risk in patients consuming cellulose by Hardman, W E, Cameron, I L, Beer, W H, Speeg, K V, Kadakia, S C, Lang, K A

“…Data from rat experimental carcinogenesis studies indicate that supplemental dietary cellulose reduces the incidence of colon cancer. Epidemiology studies also…”
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Age-dependent sensitization to oxidative stress by dietary fatty acids by Barnes, C J, Hardman, W E, Maze, G L, Lee, M, Cameron, I L

“…Experiments were designed to test the hypothesis that short-term feeding of a high polyunsaturated fatty acid (PUFA) diet would increase susceptibility to…”
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Zinc deprivation promotes progression of 1,2-dimethylhydrazine-induced colon tumors but reduces malignant invasion in mice by Carter, J.W, Lancaster, H, Hardman, W.E, Cameron, I.L

“…The aim of this study was to characterize colon tumor development and invasiveness associated with dietary zinc deprivation. Colon carcinogenesis was initiated…”
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Aspirin suppresses 1,2-dimethylhydrazine-induced alteration of proliferative parameters in rat colonic crypts by Barnes, C J, Lee, M, Hardman, W E, Cameron, I L

“…Human epidemiological reports and rodent experimental research data indicate a possible chemopreventive effect of regular aspirin use for decreasing risk of…”
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