Search Results - "HARDIN, John A"

Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model by Zhang, Zhuo, Leong, Daniel J, Xu, Lin, He, Zhiyong, Wang, Angela, Navati, Mahantesh, Kim, Sun J, Hirsh, David M, Hardin, John A, Cobelli, Neil J, Friedman, Joel M, Sun, Hui B

“…Curcumin has been shown to have chondroprotective potential in vitro. However, its effect on disease and symptom modification in osteoarthritis (OA) is largely…”
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Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model by Leong, Daniel J, Choudhury, Marwa, Hanstein, Regina, Hirsh, David M, Kim, Sun Jin, Majeska, Robert J, Schaffler, Mitchell B, Hardin, John A, Spray, David C, Goldring, Mary B, Cobelli, Neil J, Sun, Hui B

“…Abstract Introduction Epigallocatechin 3-gallate (EGCG), a polyphenol present in green tea, was shown to exert chondroprotective effects in vitro . In this…”
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Factors modulating expression of Renilla luciferase from control plasmids used in luciferase reporter gene assays by Shifera, Amde Selassie, Hardin, John A.

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The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus by Ben-Zvi, Ilan, Aranow, Cynthia, Mackay, Meggan, Stanevsky, Anfisa, Kamen, Diane L, Marinescu, L Manuela, Collins, Christopher E, Gilkeson, Gary S, Diamond, Betty, Hardin, John A

“…Excessive activity of dendritic cells (DCs) is postulated as a central disease mechanism in Systemic Lupus Erythematosus (SLE). Vitamin D is known to reduce…”
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Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis by Leong, Daniel J, Choudhury, Marwa, Hirsh, David M, Hardin, John A, Cobelli, Neil J, Sun, Hui B

“…Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest…”
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Procyanidins Mitigate Osteoarthritis Pathogenesis by, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling by Wang, Angela, Leong, Daniel J, He, Zhiyong, Xu, Lin, Liu, Lidi, Kim, Sun Jin, Hirsh, David M, Hardin, John A, Cobelli, Neil J, Sun, Hui B

“…Procyanidins are a family of plant metabolites that have been suggested to mitigate osteoarthritis pathogenesis in mice. However, the underlying mechanism is…”
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Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model by Leong, Daniel J, Choudhury, Marwa, Hanstein, Regina, Hirsh, David M, Kim, Sun Jin, Majeska, Robert J, Schaffler, Mitchell B, Hardin, John A, Spray, David C, Goldring, Mary B, Cobelli, Neil J, Sun, Hui B

“…Following publication of the original article [1], the authors reported an error in Figs. 2C and 5C…”
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Dendritic cell-mediated in vivo bone resorption by Maitra, Radhashree, Follenzi, Antonia, Yaghoobian, Arash, Montagna, Cristina, Merlin, Simone, Cannizzo, Elvira S, Hardin, John A, Cobelli, Neil, Stanley, E Richard, Santambrogio, Laura

“…Osteoclasts are resident cells of the bone that are primarily involved in the physiological and pathological remodeling of this tissue. Mature osteoclasts are…”
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PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins by Shifera, Amde Selassie, Hardin, John A.

“…The herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) promoter contains elements involved in both constitutive and induced expression. We determined…”
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The Kentucky African American Encyclopedia by Smith, Gerald L, McDaniel, Karen Cotton, Hardin, John A

“…The story of African Americans in Kentucky is as diverse and vibrant as the state's general history. The work of more than 150 writers,The Kentucky African…”
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Consequences of metabolic and oxidative modifications of cartilage tissue by Hardin, John A., Cobelli, Neil, Santambrogio, Laura

“…Key Points Diabetes, metabolic syndrome and chronic infections increase glycaemia, lipidaemia and cellular levels of reactive oxygen species (ROS) and reactive…”
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Mechanotransduction and cartilage integrity by Leong, Daniel J., Hardin, John A., Cobelli, Neil J., Sun, Hui B.

“…Osteoarthritis (OA) is characterized by the breakdown of articular cartilage that is mediated in part by increased production of matrix metalloproteinases…”
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CITED2 mediates the cross‐talk between mechanical loading and IL‐4 to promote chondroprotection by He, Zhiyong, Leong, Daniel J., Xu, Lin, Hardin, John A., Majeska, Robert J., Schaffler, Mitchell B., Thi, Mia M., Yang, Liu, Goldring, Mary B., Cobelli, Neil J., Sun, Hui B.

“…Osteoarthritis (OA) pathogenesis is mediated largely through the actions of proteolytic enzymes such as matrix metalloproteinase (MMP) 13. The transcriptional…”
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Fifty Years of Segregation. Black Higher Education in Kentucky, 1904-1954 by Hardin, John A

“…This book examines the history of 20th century racial segregation in Kentucky higher education, the last state in the South to enact legislation banning…”
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A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. III. Comparative performance characteristics of academic and manufacturers' laboratories by FRITZLER, Marvin J, WIIK, Allan, MAINI, Ravinder N, REEVES, Westley H, ROTHFIELD, Naomi F, TAKASAKI, Yoshinari, WILSON, Merlin, BYRD, Martha G, SLIVKA, Lloyd, KOZIOL, James A, TAN, Eng M, SMOLEN, Josef S, MCDOUGAL, J. Steven, CHAN, Edward K. L, GORDON, Thomas P, HARDIN, John A, KALDEN, Joachim R, LAHITA, Robert G

“…OBJECTIVE: To analyze the performance of different commercial enzyme immunoassay (EIA) kits for measuring antinuclear antibodies (ANA) specific for dsDNA,…”
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A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus by Diamond, Betty, DeGiorgio, Lorraine A, Konstantinov, Konstantin N, Lee, Sunhee C, Hardin, John A, Volpe, Bruce T

“…In systemic lupus erythematosus, antibodies against double-stranded DNA are a major contributor to renal disease. We have previously demonstrated that the…”
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Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus by PRABHAKARAN, Shyam, BRAMLAGE, Matthew, EDGAR, Mark A, DIAMOND, Betty, HARDIN, John A, VOLPE, Bruce T

“…We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain…”
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Age-Related Carbonylation of Fibrocartilage Structural Proteins Drives Tissue Degenerative Modification by Scharf, Brian, Clement, Cristina C., Yodmuang, Supansa, Urbanska, Aleksandra M., Suadicani, Sylvia O., Aphkhazava, David, Thi, Mia M., Perino, Giorgio, Hardin, John A., Cobelli, Neil, Vunjak-Novakovic, Gordana, Santambrogio, Laura

“…Aging-related oxidative stress has been linked to degenerative modifications in different organs and tissues. Using redox proteomic analysis and illustrative…”
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Osteoarthritis: A Perspective from the Arthritis Foundation: We Need a Base Hit by Hardin, John A.

“…Issue Title: Special Issue: HSS Osteoarthritis Symposium: Frontiers in OA…”
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Directing autoimmunity to nucleoprotein particles: the impact of dendritic cells and interferon alpha in lupus by Hardin, John A

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