Search Results - "HARDER, W"

Solar-Cycle Variability Results from the Solar Radiation and Climate Experiment (SORCE) Mission by Woods, Thomas N., Harder, Jerald W., Kopp, Greg, Snow, Martin

“…The Solar Radiation and Climate Experiment (SORCE) was a NASA mission that operated from 2003 to 2020 to provide key climate-monitoring measurements of total…”
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An influence of solar spectral variations on radiative forcing of climate by Haigh, Joanna D, Winning, Ann R, Toumi, Ralf, Harder, Jerald W

“…The thermal structure and composition of the atmosphere is determined fundamentally by the incoming solar irradiance. Radiation at ultraviolet wavelengths…”
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Overview of the Solar Radiation and Climate Experiment (SORCE) Seventeen-Year Mission by Woods, Thomas N., Harder, Jerald W., Kopp, Greg, McCabe, Debra, Rottman, Gary, Ryan, Sean, Snow, Martin

“…The Solar Radiation and Climate Experiment (SORCE) was a NASA mission that operated from 2003 to 2020 to provide key climate-monitoring measurements of total…”
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Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases by Shio, Marina Tiemi, Tiemi Shio, Marina, Eisenbarth, Stephanie C, Savaria, Myriam, Vinet, Adrien F, Bellemare, Marie-Josée, Harder, Kenneth W, Sutterwala, Fayyaz S, Bohle, D Scott, Descoteaux, Albert, Flavell, Richard A, Olivier, Martin

“…The intraerythrocytic parasite Plasmodium -- the causative agent of malaria -- produces an inorganic crystal called hemozoin (Hz) during the heme…”
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Regional climate impacts of a possible future grand solar minimum by Ineson, Sarah, Maycock, Amanda C., Gray, Lesley J., Scaife, Adam A., Dunstone, Nick J., Harder, Jerald W., Knight, Jeff R., Lockwood, Mike, Manners, James C., Wood, Richard A.

“…Any reduction in global mean near-surface temperature due to a future decline in solar activity is likely to be a small fraction of projected anthropogenic…”
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Trends in solar spectral irradiance variability in the visible and infrared by Harder, Jerald W., Fontenla, Juan M., Pilewskie, Peter, Richard, Erik C., Woods, Thomas N.

“…The Spectral Irradiance Monitor (SIM) on‐board the Solar Radiation and Climate Experiment (SORCE) satellite provides the first multi‐year continuous…”
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Solar Irradiance Reference Spectra (SIRS) for the 2008 Whole Heliosphere Interval (WHI) by Woods, Thomas N., Chamberlin, Phillip C., Harder, Jerald W., Hock, Rachel A., Snow, Martin, Eparvier, Francis G., Fontenla, Juan, McClintock, William E., Richard, Erik C.

“…The IHY2007 Whole Heliosphere Interval (WHI) for solar Carrington Rotation 2068 (20 March to 16 April 2008) has been very successful in obtaining a wide…”
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Lyn Tyrosine Kinase: Accentuating the Positive and the Negative by Xu, Yuekang, Harder, Kenneth W., Huntington, Nicholas D., Hibbs, Margaret L., Tarlinton, David M.

“…Lyn, one of several Src-family tyrosine kinases in immune cells, is noted for its ability to negatively regulate signaling pathways through phosphorylation of…”
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Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase by Odom, Sandra, Gomez, Gregorio, Kovarova, Martina, Furumoto, Yasuko, Ryan, John J, Wright, Harry V, Gonzalez-Espinosa, Claudia, Hibbs, Margaret L, Harder, Kenneth W, Rivera, Juan

“…A role for Lyn kinase as a positive regulator of immunoglobulin (Ig)E-dependent allergy has long been accepted. Contrary to this belief, Lyn kinase was found…”
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The impact of solar spectral irradiance variability on middle atmospheric ozone by Merkel, Aimee W., Harder, Jerald W., Marsh, Daniel R., Smith, Anne K., Fontenla, Juan M., Woods, Thomas N.

“…This study presents the impact of solar spectral irradiance (SSI) variability on middle atmospheric ozone over the declining phase of solar cycle 23. Two…”
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Analysis of acrylamide in different foodstuffs using liquid chromatography–tandem mass spectrometry and gas chromatography–tandem mass spectrometry by Hoenicke, K., Gatermann, R., Harder, W., Hartig, L.

“…Acrylamide levels over a wide range of different food products were analysed using both liquid chromatography–tandem mass spectrometry (HPLC–MS–MS) and gas…”
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Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles by Yang, Zhi, Leon, Jeffrey, Martin, Mike, Harder, John W, Zhang, Rui, Liang, Dong, Lu, Wei, Tian, Mei, Gelovani, Juri G, Qiao, Alex, Li, Chun

“…There has been increased interest in the use of polymeric nanoparticles as carriers for near-infrared fluorescence (NIRF) dyes for cancer diagnosis. However,…”
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Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity by Hibbs, Margaret L, Harder, Kenneth W, Armes, Jane, Kountouri, Nicole, Quilici, Cathy, Casagranda, Franca, Dunn, Ashley R, Tarlinton, David M

“…Genetic ablation of the Lyn tyrosine kinase has revealed unique inhibitory roles in B lymphocyte signaling. We now report the consequences of sustained…”
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The Infrared Solar Spectrum Measured by the SOLSPEC Spectrometer Onboard the International Space Station by Thuillier, G., Harder, J. W., Shapiro, A., Woods, T. N., Perrin, J.-M., Snow, M., Sukhodolov, T., Schmutz, W.

“…A solar spectrum extending from the extreme ultraviolet to the near-infrared is an important input for solar physics, climate research, and atmospheric…”
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The SORCE SIM Solar Spectrum: Comparison with Recent Observations by Harder, J. W., Thuillier, G., Richard, E. C., Brown, S. W., Lykke, K. R., Snow, M., McClintock, W. E., Fontenla, J. M., Woods, T. N., Pilewskie, P.

“…The Spectral Irradiance Monitor (SIM) on board the NASA SORCE satellite (Solar Radiation and Climate Experiment) was launched on 25 January 2003 and has been…”
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Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells by Bishop, J L, Roberts, M E, Beer, J L, Huang, M, Chehal, M K, Fan, X, Fouser, L A, Ma, H L, Bacani, J T, Harder, K W

“…Intestinal homeostasis requires a complex balance of interactions between diverse resident microbial communities, the intestinal epithelium, and the underlying…”
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Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2 by McColl, Bradley K, Paavonen, Karri, Karnezis, Tara, Harris, Nicole C, Davydova, Natalia, Rothacker, Julie, Nice, Edouard C, Harder, Kenneth W, Roufail, Sally, Hibbs, Margaret L, Rogers, Peter A.W, Alitalo, Kari, Stacker, Steven A, Achen, Marc G

“…Vascular endothelial growth factor (VEGF)-D is a secreted glycoprotein that induces angiogenesis and lymphangiogenesis. It consists of a central domain,…”
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Midlatitude atmospheric OH response to the most recent 11-y solar cycle by Wang, Shuhui, Li, King-Fai, Pongetti, Thomas J., Sander, Stanley P., Yung, Yuk L., Liang, Mao-Chang, Livesey, Nathaniel J., Santee, Michelle L., Harder, Jerald W., Snow, Martin, Mills, Franklin P.

“…The hydroxyl radical (OH) plays an important role in middle atmospheric photochemistry, particularly in ozone (O ₃) chemistry. Because it is mainly produced…”
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2B4-SAP signaling is required for the priming of naive CD8+ T cells by antigen-expressing B cells and B lymphoma cells by Huang, Yu-Hsuan, Tsai, Kevin, Tan, Sara Y., Kang, Sohyeong, Ford, Mandy L., Harder, Kenneth W., Priatel, John J.

“…Mutations in SH2D1A gene that encodes SAP (SLAM-associated protein) result in X-linked lymphoproliferative disease (XLP), a rare primary immunodeficiency…”
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Gain- and Loss-of-Function Lyn Mutant Mice Define a Critical Inhibitory Role for Lyn in the Myeloid Lineage by Harder, Kenneth W., Parsons, Linda M., Armes, Jane, Evans, Natalie, Kountouri, Nicole, Clark, Roslyn, Quilici, Cathy, Grail, Dianne, Hodgson, George S., Dunn, Ashley R., Hibbs, Margaret L.

“…To investigate the role of the Lyn kinase in establishing signaling thresholds in hematopoietic cells, a gain-of-function mutation analogous to the Src…”
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