Search Results - "HARASAWA, Hitomi"

Analysis of Predictive Factors for Diarrhea after the Administration of Naldemedine by Hashizume, Junya, Shiojiri, Kyohei, Ryu, Emi, Kawauchi, Yuki, Hasegawa, Kyoko, Ezaki, Nozomi, Yamashita, Haruna, Ishii, Koji, Harasawa, Hitomi, Nakamura, Tadahiro, Sasaki, Hitoshi, Kodama, Yukinobu

“…Naldemedine (NAL), a peripherally acting μ-opioid receptor antagonist, is effective for opioid-induced constipation (OIC). However, diarrhea is the most common…”
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Methotrexate-Coated Complexes of Plasmid DNA and Polyethylenimine for Gene Delivery by Kodama, Yukinobu, Noda, Ryo, Sato, Kayoko, Harasawa, Hitomi, Kurosaki, Tomoaki, Nakagawa, Hiroo, Nakamura, Tadahiro, Kitahara, Takashi, Muro, Takahiro, Sasaki, Hitoshi

“…Folate receptors are overexpressed on the surface cancer cells. We successfully constructed a new gene delivery vector of methotrexate (MTX)-coated plasmid…”
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Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery by Hamada, Eri, Kurosaki, Tomoaki, Hashizume, Junya, Harasawa, Hitomi, Nakagawa, Hiroo, Nakamura, Tadahiro, Kodama, Yukinobu, Sasaki, Hitoshi

“…We previously found that a complex comprising plasmid DNA (pDNA), polyethylenimine (PEI), and γ-polyglutamic acid (γ-PGA) had high transgene efficiency without…”
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Effects of changing the timing of warfarin administration in combination with fluconazole on prolongation of the PT-INR: a case report by Akamatsu, Hayato, Nakagawa, Hiroo, Matsumaru, Ichiro, Hashizume, Junya, Harasawa, Hitomi, Kodama, Yukinobu, Miura, Takashi, Ohyama, Kaname

“…Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the…”
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Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle by Kurosaki, Tomoaki, Katafuchi, Yuki, Hashizume, Junya, Harasawa, Hitomi, Nakagawa, Hiroo, Nakashima, Mikiro, Nakamura, Tadahiro, Yamashita, Chikamasa, Sasaki, Hitoshi, Kodama, Yukinobu

“…We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type…”
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Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis by Kurosaki, Tomoaki, Kanda, Hiroki, Hashizume, Junya, Sato, Kayoko, Harasawa, Hitomi, Nakamura, Tadahiro, Sasaki, Hitoshi, Kodama, Yukinobu

“…In a previous study, we constructed a lung-targeting lipopolyplex containing polyethyleneimine (PEI), 1,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA),…”
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Development of a DNA Vaccine for Melanoma Metastasis by Inhalation Based on an Analysis of Transgene Expression Characteristics of Naked pDNA and a Ternary Complex in Mouse Lung Tissues by Kodama, Yukinobu, Nakashima, Mikiro, Nagahara, Tadayuki, Oyama, Natsuko, Hashizume, Junya, Nakagawa, Hiroo, Harasawa, Hitomi, Muro, Takahiro, Kurosaki, Tomoaki, Yamashita, Chikamasa, Hashida, Mitsuru, Kitahara, Takashi, Sasaki, Hitoshi, Kawakami, Shigeru, Nakamura, Tadahiro

“…The present study investigated a pulmonary delivery system of plasmid DNA (pDNA) and its application to melanoma DNA vaccines. pCMV-Luc, pEGFP-C1, and pZsGreen…”
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Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice by Kodama, Yukinobu, Tokunaga, Ayako, Hashizume, Junya, Nakagawa, Hiroo, Harasawa, Hitomi, Kurosaki, Tomoaki, Nakamura, Tadahiro, Nishida, Koyo, Nakashima, Mikiro, Hashida, Mitsuru, Kawakami, Shigeru, Sasaki, Hitoshi

“…We developed a biocompatible splenic vector for a DNA vaccine against melanoma. The splenic vector is a ternary complex composed of plasmid DNA (pDNA),…”
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Splenic Gene Delivery System Using Self-assembling Nano-complex with Phosphatidylserine Analog by Kurosaki, Tomoaki, Nakasone, Chihiro, Kodama, Yukinobu, Egashira, Kanoko, Harasawa, Hitomi, Muro, Takahiro, Nakagawa, Hiroo, Kitahara, Takashi, Higuchi, Norihide, Nakamura, Tadahiro, Sasaki, Hitoshi

“…The recognition of phosphatidylserine on the erythrocyte membrane mediates erythrophagocytosis by resident spleen macrophages. The application of…”
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A Novel Alternative Splicing Isoform of Human T-Cell Leukemia Virus Type 1 bZIP Factor (HBZ-SI) Targets Distinct Subnuclear Localization by MURATA, Ken, HAYASHIBARA, Toshihisa, MIYANISHI, Takayuki, YAMADA, Yasuaki, KAMIHIRA, Shimeru, SUGAHARA, Kazuyuki, UEMURA, Akiko, YAMAGUCHI, Taku, HARASAWA, Hitomi, HASEGAWA, Hiroo, TSURUDA, Kazuto, OKAZAKI, Toshiro, KOJI, Takehiko

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Clinical and oncologic implications in epigenetic down-regulation of CD26/ dipeptidyl peptidase IV in adult T-cell leukemia cells by TSUJI, Tomohiro, SUGAHARA, Kazuyuki, TSURUDA, Kazuto, UEMURA, Akiko, HARASAWA, Hitomi, HASEGAWA, Hiroo, HAMAGUCHI, Yukio, TOMONAGA, Masao, YAMADA, Yasuaki, KAMIHIRA, Shimeru

“…CD26/dipeptidyl peptidase IV (DPPIV), a T-cell-activation antigen, is a 110-kD type II surface glycoprotein expressed on various types of normal cells…”
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Splenic Gene Delivery System Using Self-assembling Nano-complex with Phosphatidylserine Analog by Tomoaki Kurosaki, Chihiro Nakasone, Yukinobu Kodama, Kanoko Egashira, Hitomi Harasawa, Takahiro Muro, Hiroo Nakagawa, Takashi Kitahara, Norihide Higuchi, Tadahiro Nakamura, Hitoshi Sasaki

“…The recognition of phosphatidylserine on the erythrocyte membrane mediates erythrophagocytosis by resident spleen macrophages. The application of…”
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Clinical relevance of survivin as a biomarker in neoplasms, especially in adult T-cell leukemias and acute leukemias by SUGAHARA, Kazuyuki, UEMURA, Akiko, YAMADA, Yasuaki, KAMIHIRA, Shimeru, HARASAWA, Hitomi, NAGAI, Hiroshi, HIRAKATA, Yoichi, TOMONAGA, Masao, MURATA, Kenn, SOHDA, Hiroshi, NAKAGOE, Toru, SHIBASAKI, Sin-Ichi

“…Survivin has been identified as one of the top 4 transcripts among 3.5 million human transcriptomes uniformly up-regulated in cancer tissues but not in normal…”
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Poor Renal Function and a High Modified Glasgow Prognostic Score Are Predictive Factors for Nedaplatin/5-Fluorouracil Combination Therapy-induced Febrile Neutropenia by Hashizume, Junya, Nambu, Madoka, Nakagawa, Hiroo, Harasawa, Hitomi, Kodama, Yukinobu

“…Nedaplatin (NDP)/5-fluorouracil (5-FU) combination therapy frequently causes severe neutropenia and febrile neutropenia (FN). However, there is no consensus on…”
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Possible attenuation of Fas-mediated signaling by dominant expression of caspase-8 aberrant isoform in adult T-cell leukemia cells by SUGAHARA, Kazuyuki, HAYASHI, Tomomi, DATEKI, Natsuko, HIRAKATA, Yoichi, HARASAWA, Hitomi, TOMONAGA, Masao, YAMADA, Yasuaki, KAMIHIRA, Shimeru

“…The Fas up-regulated in adult T-cell leukemia (ATL) cells is usually the wild-type protein and is usually functional, at least in vitro. However, primary ATL…”
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Selective oxidation of 1,2-diols by electrochemical method using organotin compound and bromide ion as mediators by Maki, Toshihide, Fukae, Kazuhiro, Harasawa, Hitomi, Ohishi, Takahiro, Matsumura, Yoshihiro, Onomura, Osamu

“…A new electrochemical method for a selective oxidation of 1,2-diols to keto alcohols was explored. The method used dibutyltin oxide and bromide ion as…”
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Efficient Oxidation of 1,2-Diols into α-Hydroxyketones Catalyzed by Organotin Compounds by Maki, Toshihide, Iikawa, Shinya, Mogami, Gen, Harasawa, Hitomi, Matsumura, Yoshihiro, Onomura, Osamu

“…Get selective! A selective oxidation of 1,2‐diols to α‐hydroxyketones catalyzed by organotin compounds has been developed (see scheme). Invaluable chemo‐ and…”
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Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1–transformed T cells by Yoshie, Osamu, Fujisawa, Ryuichi, Nakayama, Takashi, Harasawa, Hitomi, Tago, Hideaki, Izawa, Dai, Hieshima, Kunio, Tatsumi, Youichi, Matsushima, Kouji, Hasegawa, Hitoshi, Kanamaru, Akihisa, Kamihira, Shimeru, Yamada, Yasuaki

“…Chemokines and chemokine receptors play important roles in migration and tissue localization of various lymphocyte subsets. Here, we report the highly frequent…”
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Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer by Kurosaki, Tomoaki, Yamashita, Yumi, Aki, Keisei, Harasawa, Hitomi, Nakagawa, Hiroo, Kodama, Yukinobu, Higuchi, Norihide, Nakamura, Tadahiro, Kitahara, Takashi, Sasaki, Hitoshi

“…The purpose of this study was to develop a new type of gene vector, polyamidoamine (PAMAM) dendriplex pharmaceutically modified, based on electrostatic…”
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Aberrant expression of caspase cascade regulatory genes in adult T‐cell leukaemia: survivin is an important determinant for prognosis by Kamihira, Shimeru, Yamada, Yasuaki, Hirakata, Yoichi, Tomonaga, Masao, Sugahara, Kazuyuki, Hayashi, Tomoni, Dateki, Natsuko, Harasawa, Hitomi, Nakayama, Katsushi

“…Derangement of either apoptosis or cell division is known to play an important role in tumorigenesis. Fas‐mediated apoptosis on normal and leukaemic T cells is…”
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