Search Results - "HARAMAKI, N"

Statins for heart failure: a potential for new treatment by Haramaki, Nobuya, Ikeda, Hisao

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Oxidative stress is related to exercise intolerance in patients with heart failure by Nishiyama, Yasuhiro, Ikeda, Hisao, Haramaki, Nobuya, Yoshida, Noriko, Imaizumi, Tsutomu

“…To assess the role of oxidative stress in exercise intolerance in patients with heart failure, a symptom-limited exercise test was performed with a bicycle…”
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Glutathione Reductase and Lipoamide Dehydrogenase Have Opposite Stereospecificities for α-Lipoic Acid Enantiomers by Pick, U., Haramaki, N., Constantinescu, A., Handelman, G.J., Tritschler, H.J., Packer, L.

“…The reduction of exogenous α-lipoic acid to dihydrolipoate by mammalian cells and tissues confers additional antioxidant protection to the cell. Both (R+) and…”
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DNA Single-Strand Breaks and Cytotoxicity Induced by Chromate(VI), Cadmium(II), and Mercury(II) in Hydrogen Peroxide-Resistant Cell Lines by Tsuzuki, Katsuyuki, Sugiyama, Masayasu, Haramaki, Nobuya

“…The induction of cytotoxicity and DNA single-strand breaks by chromium(VI), cadmium(II), and mercury(II) were compared in H2O2-resistant Chinese hamster ovary…”
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Influence of o-phenanthroline on DNA single-strand breaks, alkali-labile sites, glutathione reductase, and formation of chromium(V) in Chinese hamster V-79 cells treated with sodium chromate (VI) by Sugiyama, M, Tsuzuki, K, Haramaki, N

“…The effect of the cell-permeable metal chelator o-phenanthroline (OP) on the formation of chromium(V), DNA breaks, alkali-labile sites, and enzyme inhibition…”
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Platelet P-selectin plays an important role in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates by Yokoyama, Shinji, Ikeda, Hisao, Haramaki, Nobuya, Yasukawa, Hideo, Murohara, Toyoaki, Imaizumi, Tsutomu

“…We investigated the role of P-selectin in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates. Plaque rupture followed by thrombus…”
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Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers by Morita, Hirohiko, Ikeda, Hisao, Haramaki, Nobuya, Eguchi, Hiroyuki, Imaizumi, Tsutomu

“…We investigated whether and how soon smoking cessation ameliorates the smoking-induced intracellular oxidative stress and platelet aggregability in long-term…”
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Augmented oxidative stress of platelets in Chronic smokers : Mechanisms of Impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability by TAKAJO, Yoshinori, IKEDA, Hisao, HARAMAKI, Nobuya, MUROHARA, Toyoaki, IMAIZUMI, Tsutomu

“…We investigated whether impaired platelet-derived nitric oxide (PDNO) bioactivity and augmented platelet aggregability in chronic smokers are related to the…”
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Polymorphonuclear Leukocytes May Impair Endothelial Function: Results of Crossover Randomized Study of Lipid-Lowering Therapies by Sugano, Ryo, Matsuoka, Hidehiro, Haramaki, Nobuya, Umei, Hidekazu, Murase, Eiko, Fukami, Kei, Iida, Shuji, Ikeda, Hisao, Imaizumi, Tsutomu

“…OBJECTIVES—To examine whether polymorphonuclear leukocytes (PMNs) in hypercholesterolemia (HC) are activated to generate large amount of superoxide in vivo and…”
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Intra-coronary administration of L-arginine aggravates myocardial stunning through production of peroxynitrite in dogs by MORI, E, HARAMAKI, N, IKEDA, H, IMAIZUMI, T

“…The aim of this study was to investigate how the enhanced nitric oxide (NO) production by intra-coronary infusion of L-arginine acts in myocardial stunning in…”
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Networking Antioxidants in the Isolated Rat Heart are Selectively Depleted by Ischemia-Reperfusion by Haramaki, Nobuya, Stewart, Daphne B, Aggarwal, Sarita, Ikeda, Hisao, Reznick, Abraham Z, Packer, Lester

“…Although cardiac endogenous antioxidants have been reported to be oxidized and decreased by ischemia-reperfusion, little is known whether the changes in these…”
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Inhibition of platelet adherence to mononuclear cells by alpha-tocopherol: role of P-selectin by Murohara, Toyoaki, Ikeda, Hisao, Otsuka, Yoritaka, Aoki, Mika, Haramaki, Nobuya, Katoh, Atsushi, Takajo, Yoshinori, Imaizumi, Tsutomu

“…Platelet-leukocyte interaction is an early important event for thrombogenesis, and this process is mainly mediated by P-selectin on platelets. Although…”
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HMG-CoA Reductase Inhibitor Protects Against In Vivo Arterial Thrombosis by Augmenting Platelet-Derived Nitric Oxide Release in Rats by Yokoyama, Shinji, Ikeda, Hisao, Haramaki, Nobuya, Yasukawa, Hideo, Katoh, Atsushi, Imaizumi, Tsutomu

“…Acute coronary syndromes are caused by platelet-mediated thrombosis following rupture of a plaque. HMG-CoA reductase inhibitors (statins) reduce the incidence…”
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Cytosolic and Mitochondrial Systems for NADH- and NADPH-dependent Reduction of α-Lipoic Acid by Haramaki, Nobuya, Han, Derick, Handelman, Garry J, Tritschler, Hans J, Packer, Lester

“…In cellular, tissue, and organismal systems, exogenously supplied α-lipoic acid (thioctic acid) has a variety of significant effects, including direct radical…”
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Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation by KANAYA, Seiji, IKEDA, Hisao, HARAMAKI, Nobuya, MUROHARA, Toyoaki, IMAIZUMI, Tsutomu

“…Platelet-derived nitric oxide inhibits platelet aggregation via constitutive NO synthase (NOS). Tetrahydrobiopterin (BH(4)), a cofactor of NOS, augments NO…”
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Protective effects of riboflavin and its derivatives against ischemic reperfused damage of rat heart by Kotegawa, M, Sugiyama, M, Haramaki, N

“…The effects of riboflavin and its derivatives such as FAD, FMN and lumichrome on the levels of high energy phosphate compounds (ATP and creatine phosphate) and…”
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Long-term smoking impairs platelet-derived nitric oxide release by ICHIKI, K, IKEDA, H, HARMAKI, N, UENO, T, IMAIZUMI, T

“…Long-term smoking impairs endothelium-dependent vasodilation, which is mediated by nitric oxide (NO). However, it is unknown whether long-term smoking impairs…”
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The influence of vitamin E and dihydrolipoic acid on cardiac energy and glutathione status under hypoxia-reoxygenation by Haramaki, N, Assadnazari, H, Zimmer, G, Schepkin, V, Packer, L

“…The combination of vitamin E supplementation with dihydrolipoic acid perfusion synergistically improves cardiac functional recovery during post-ischemic…”
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Platelet-Derived Nitric Oxide and Coronary Risk Factors by Ikeda, Hisao, Takajo, Yoshinori, Murohara, Toyoaki, Ichiki, Kazuya, Adachi, Hisashi, Haramaki, Nobuya, Katoh, Atsushi, Imaizumi, Tsutomu

“…Platelet aggregation is inhibited through a negative feedback mechanism by the l-arginine/nitric oxide (NO) pathway found in platelets themselves. We have…”
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Vitamin E inhibits lysophosphatidylcholine-induced endothelial dysfunction and platelet activation by Murohara, Toyoaki, Ikeda, Hisao, Katoh, Atsushi, Takajo, Yoshinori, Otsuka, Yoritaka, Haramaki, Nobuya, Imaizumi, Tsutomu

“…Lysophosphatidylcholine (LPC), a lysolipid contained in oxidized low-density lipoprotein, is an atherogenic molecule that induces endothelial dysfunction and…”
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