CYP17 and breast cancer risk : The polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1

CYP17 and breast cancer risk : The polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1

The ability of a motif of the CYP17 5' untranslated region, created by a polymorphic T to C substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of any of the polymorphic alleles was observed in electromobility shift assay. No other sequence within +1 to +10...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Vol. 59; no. 12; pp. 2825 - 2828
Main Authors: KRISTENSEN, V. N, HARALDSEN, E. K, ANDERSON, K. B, LØNNING, P. E, ERIKSTEIN, B, KARESEN, R, GABRIELSEN, O. S, BØRRESEN-DALE, A.-L
Format: Journal Article
Language:English
Published: Philadelphia, PA American Association for Cancer Research 15-06-1999
Subjects:
5' Untranslated Regions - metabolism
Adult
Aged
Aged, 80 and over
Alleles
Base Sequence
Biological and medical sciences
Breast Neoplasms - genetics
Female
Genotype
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Molecular Sequence Data
Polymorphism, Genetic
Risk Factors
Sequence Alignment
Sp1 Transcription Factor - metabolism
Steroid 17-alpha-Hydroxylase - genetics
Tumors
Human
5' terminal-Sequence
Leukocyte
Cytochrome P450
Genotype
Molecular interaction
Binding site
Flanking sequence
Malignant tumor
Mammary gland diseases
Transcription factor Sp1
Risk factor
Genetics
Female
Mammary gland
Polymorphism
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Summary:The ability of a motif of the CYP17 5' untranslated region, created by a polymorphic T to C substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of any of the polymorphic alleles was observed in electromobility shift assay. No other sequence within +1 to +100 of each of the CYP17 alleles formed complex with the Sp-1 or enhanced binding to the polymorphic CACC box. Genotyping of 510 breast cancer patients and 201 controls revealed no difference in genotype frequencies. Age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype.
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ISSN:0008-5472
1538-7445