Search Results - "HAQUE, S. Jaharul"

Tumor Heterogeneity in Glioblastomas: From Light Microscopy to Molecular Pathology by Becker, Aline P, Sells, Blake E, Haque, S Jaharul, Chakravarti, Arnab

“…One of the main reasons for the aggressive behavior of glioblastoma (GBM) is its intrinsic intra-tumor heterogeneity, characterized by the presence of clonal…”
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Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells by SHAIK OHIDAR RAHAMAN, HARBOR, Phyllis C, CHERNOVA, Olga, BARNETT, Gene H, VOGELBAUM, Michael A, JAHARUL HAQUE, S

“…Glioblastoma multiforme (GBM), the most common and malignant central nervous system tumor in humans, is highly proliferative and resistant to apoptosis. Stat3,…”
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TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways by Singh, Karnika, Han, Chunhua, Fleming, Jessica L., Becker, Aline P., McElroy, Joseph, Cui, Tiantian, Johnson, Benjamin, Kumar, Ashok, Sebastian, Ebin, Showalter, Christian A., Schrock, Morgan S., Summers, Matthew K., Becker, Valesio, Tong, Zhen-yue, Meng, Xiaomei, Manring, Heather R., Venere, Monica, Bell, Erica H., Robe, Pierre A., Grosu, A. L., Haque, S. Jaharul, Chakravarti, Arnab

“…GBM (Glioblastoma) is the most lethal CNS (Central nervous system) tumor in adults, which inevitably develops resistance to standard treatments leading to…”
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STAT3-mediated Coincidence Detection Regulates Noncanonical Immediate Early Gene Induction by Waitkus, Matthew S., Chandrasekharan, Unni M., Willard, Belinda, Haque, S.Jaharul, DiCorleto, Paul E.

“…Signaling pathways interact with one another to form dynamic networks in which the cellular response to one stimulus may depend on the presence, intensity,…”
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Pediatric hypereosinophilic syndrome (HES) differs from adult HES by Katz, Hary T., Haque, S. Jaharul, Hsieh, Fred H.

“…The idiopathic hypereosinophilic syndrome (HES) developed in a 15-year-old boy who presented with colitis, cough, rash, and hepatitis. Molecular analysis…”
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PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells by GHOSH, Mrinal K, SHARMA, Pankaj, HARBOR, Phyllis C, RAHAMAN, Shaik O, HAQUE, S. Jaharul

“…Glioblastoma multiforme (GBM) cells frequently harbor amplification and/or gain-of-function mutation of the EGFR gene leading to the activation of multiple…”
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The Role of miRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas by Beyer, Sasha, Fleming, Jessica, Meng, Wei, Singh, Rajbir, Haque, S Jaharul, Chakravarti, Arnab

“…MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that function in gene silencing by post-transcriptional regulation of gene expression. The…”
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miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma by Cui, Tiantian, Bell, Erica H., McElroy, Joseph, Becker, Aline Paixao, Gulati, Pooja Manchanda, Geurts, Marjolein, Mladkova, Nikol, Gray, Ashley, Liu, Kevin, Yang, Linlin, Liu, Ziyan, Fleming, Jessica L., Haque, S. Jaharul, Barnholtz-Sloan, Jill S., Ligon, Keith L., Beroukhim, Rameen, Robe, Pierre, Chakravarti, Arnab

“…Glioblastomas (GBMs) are the most aggressive primary brain tumors, with an average survival of less than 15 months. Therefore, there is a critical need to…”
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MicroRNA-575 acts as a novel oncogene via targeting multiple signaling pathways in glioblastoma by Gray, Ashley, Cui, Tiantian, Bell, Erica Hlavin, McElroy, Joseph, Sebastian, Ebin, Li, Fuhai, Geurts, Marjolein, Liu, Kevin, Robe, Pierre, Haque, S. Jaharul, Chakravarti, Arnab

“…Glioblastoma (GBM) patients currently face poor survival outcomes with an average survival period of <15 months, while only 3–5% of patients survive longer…”
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Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1 by Zhuang, Dazhong, Qiu, Yaling, Haque, S. Jaharul, Dong, Fan

“…Mutations in the granulocyte‐colony stimulating factor receptor (G‐CSF‐R) gene resulting in carboxy terminal truncation have been associated with acute myeloid…”
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MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways by Estrada-Bernal, Adriana, Chatterjee, Moumita, Haque, S Jaharul, Yang, Linlin, Morgan, Meredith A, Kotian, Shweta, Morrell, David, Chakravarti, Arnab, Williams, Terence M

“…Over 90% of pancreatic adenocarcinoma PC express oncogenic mutant KRAS that constitutively activates the Raf-MEK-MAPK pathway conferring resistance to both…”
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A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma by Cui, Tiantian, Bell, Erica H, McElroy, Joseph, Liu, Kevin, Sebastian, Ebin, Johnson, Benjamin, Gulati, Pooja Manchanda, Becker, Aline Paixao, Gray, Ashley, Geurts, Marjolein, Subedi, Depika, Yang, Linlin, Fleming, Jessica L, Meng, Wei, Barnholtz-Sloan, Jill S, Venere, Monica, Wang, Qi-En, Robe, Pierre A, Haque, S Jaharul, Chakravarti, Arnab

“…Rapid tumor growth, widespread brain-invasion, and therapeutic resistance critically contribute to glioblastoma (GBM) recurrence and dismal patient outcomes…”
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STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation by Xu, Weiling, Comhair, Suzy A A, Zheng, Shuo, Chu, Shan C, Marks-Konczalik, Joanna, Moss, Joel, Haque, S Jaharul, Erzurum, Serpil C

“…Interferon-gamma (IFN-gamma) is required for induction of the human nitric oxide synthase-2 (NOS2) gene in lung epithelium. Although the human NOS2 promoter…”
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Redox Regulation of Interleukin-4 Signaling by Sharma, Pankaj, Chakraborty, Rikhia, Wang, Lu, Min, Booki, Tremblay, Michel L., Kawahara, Tsukasa, Lambeth, J. David, Haque, S. Jaharul

“…The physiologic control of cytokine receptor activation is primarily mediated by reciprocal activation of receptor-associated protein tyrosine kinases and…”
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MicroRNA Biomarkers for Patients With Muscle-Invasive Bladder Cancer Undergoing Selective Bladder-Sparing Trimodality Treatment by Meng, Wei, Efstathiou, Jason, Singh, Rajbir, McElroy, Joseph, Volinia, Stefano, Cui, Ri, Ibrahim, Ahmed, Johnson, Benjamin, Gupta, Nirmala, Mehta, Satvam, Wang, Huabao, Miller, Eric, Nguyen, Phuong, Fleming, Jessica, Wu, Chin-Lee, Haque, S. Jaharul, Shipley, William, Chakravarti, Arnab

“…Trimodality therapy with maximal transurethral resection of bladder tumor and definitive chemoradiation reserving cystectomy for salvage of local recurrence is…”
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Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas by Bredel, Markus, Espinosa, Lluís, Kim, Hyunsoo, Scholtens, Denise M., McElroy, Joseph P., Rajbhandari, Rajani, Meng, Wei, Kollmeyer, Thomas M., Malta, Tathiane M., Quezada, Michael A., Harsh, Griffith R., Lobo-Jarne, Teresa, Solé, Laura, Merati, Aran, Nagaraja, Surya, Nair, Sindhu, White, Jaclyn J., Thudi, Nanda K., Fleming, Jessica L., Webb, Amy, Natsume, Atsushi, Ogawa, Seishi, Weber, Ruthild G., Bertran, Joan, Haque, S. Jaharul, Hentschel, Bettina, Miller, C. Ryan, Furnari, Frank B., Chan, Timothy A., Grosu, Anca-Ligia, Weller, Michael, Barnholtz-Sloan, Jill S., Monje, Michelle, Noushmehr, Houtan, Jenkins, Robert B., Rogers, C. Leland, MacDonald, David R., Pugh, Stephanie L., Chakravarti, Arnab

“…Genetic alterations help predict the clinical behavior of diffuse gliomas, but some variability remains uncorrelated. Here, we demonstrate that…”
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Receptor-Associated Constitutive Protein Tyrosine Phosphatase Activity Controls the Kinase Function of JAK1 by Haque, S. Jaharul, Wu, Qian, Kammer, Winfried, Friedrich, Karlheinz, Smith, Jonathan M., Kerr, Ian M., Stark, George R., Bryan R. G. Williams

“…Exposure of cells to protein tyrosine phosphatase (PTP) inhibitors causes an increase in the phosphotyrosine content of many cellular proteins. However, the…”
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p300- and Myc-mediated regulation of glioblastoma multiforme cell differentiation by Panicker, Sreejith P, Raychaudhuri, Baisakhi, Sharma, Pankaj, Tipps, Russell, Mazumdar, Tapati, Mal, Asoke K, Palomo, Juan M, Vogelbaum, Michael A, Haque, S Jaharul

“…Tumorigenic potential of glioblastoma multiforme (GBM) cells is, in part, attributable to their undifferentiated (neural stem cell-like) phenotype. Astrocytic…”
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Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis by Zheng, Shuo, De, Bishnu P, Choudhary, Suresh, Comhair, Suzy A.A, Goggans, Tannishia, Slee, Roger, Williams, Bryan R.G, Pilewski, Joseph, Haque, S.Jaharul, Erzurum, Serpil C

“…Viral infection is the primary cause of respiratory morbidity in cystic fibrosis (CF) infants. Here, we identify that host factors allow increased virus…”
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The possible role of TGF-beta-induced suppressors of cytokine signaling expression in osteoclast/macrophage lineage commitment in vitro by Fox, Simon W, Haque, S Jaharul, Lovibond, Alison C, Chambers, Timothy J

“…Osteoclast formation is dependent on the ability of TGF-beta to enable receptor activator of NF-kappaB ligand (RANKL)-induced commitment of hemopoietic…”
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