Search Results - "HANTRAYE, Philippe"

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease by Grealish, Shane, Diguet, Elsa, Kirkeby, Agnete, Mattsson, Bengt, Heuer, Andreas, Bramoulle, Yann, Van Camp, Nadja, Perrier, Anselme L., Hantraye, Philippe, Björklund, Anders, Parmar, Malin

“…Considerable progress has been made in generating fully functional and transplantable dopamine neurons from human embryonic stem cells (hESCs). Before these…”
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Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease by Le Douce, Juliette, Maugard, Marianne, Veran, Julien, Matos, Marco, Jégo, Pierrick, Vigneron, Pierre-Antoine, Faivre, Emilie, Toussay, Xavier, Vandenberghe, Michel, Balbastre, Yaël, Piquet, Juliette, Guiot, Elvire, Tran, Nguyet Thuy, Taverna, Myriam, Marinesco, Stéphane, Koyanagi, Ayumi, Furuya, Shigeki, Gaudin-Guérif, Mylène, Goutal, Sébastien, Ghettas, Aurélie, Pruvost, Alain, Bemelmans, Alexis-Pierre, Gaillard, Marie-Claude, Cambon, Karine, Stimmer, Lev, Sazdovitch, Véronique, Duyckaerts, Charles, Knott, Graham, Hérard, Anne-Sophie, Delzescaux, Thierry, Hantraye, Philippe, Brouillet, Emmanuel, Cauli, Bruno, Oliet, Stéphane H.R., Panatier, Aude, Bonvento, Gilles

“…Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer’s disease (AD). Whether and how such metabolic dysregulation…”
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Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate by Goulay, Romain, Flament, Julien, Gauberti, Maxime, Naveau, Michael, Pasquet, Nolwenn, Gakuba, Clement, Emery, Evelyne, Hantraye, Philippe, Vivien, Denis, Aron-Badin, Romina, Gaberel, Thomas

“…BACKGROUND AND PURPOSE—Subarachnoid hemorrhage (SAH) is a devastating form of stroke with neurological outcomes dependent on the occurrence of delayed cerebral…”
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MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates by Aron Badin, Romina, Bugi, Aurore, Williams, Susannah, Vadori, Marta, Michael, Marie, Jan, Caroline, Nassi, Alberto, Lecourtois, Sophie, Blancher, Antoine, Cozzi, Emanuele, Hantraye, Philippe, Perrier, Anselme L.

“…Cell therapy products (CTP) derived from pluripotent stem cells (iPSCs) may constitute a renewable, specifically differentiated source of cells to potentially…”
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Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging by Lavisse, Sonia, Guillermier, Martine, Hérard, Anne-Sophie, Petit, Fanny, Delahaye, Marion, Van Camp, Nadja, Ben Haim, Lucile, Lebon, Vincent, Remy, Philippe, Dollé, Frédéric, Delzescaux, Thierry, Bonvento, Gilles, Hantraye, Philippe, Escartin, Carole

“…Astrocytes and microglia become reactive under most brain pathological conditions, making this neuroinflammation process a surrogate marker of neuronal…”
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Ectosomes: a new mechanism for non-exosomal secretion of tau protein by Dujardin, Simon, Bégard, Séverine, Caillierez, Raphaëlle, Lachaud, Cédrick, Delattre, Lucie, Carrier, Sébastien, Loyens, Anne, Galas, Marie-Christine, Bousset, Luc, Melki, Ronald, Aurégan, Gwennaëlle, Hantraye, Philippe, Brouillet, Emmanuel, Buée, Luc, Colin, Morvane

“…Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be…”
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The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases by Ben Haim, Lucile, Ceyzériat, Kelly, Carrillo-de Sauvage, Maria Angeles, Aubry, Fabien, Auregan, Gwennaëlle, Guillermier, Martine, Ruiz, Marta, Petit, Fanny, Houitte, Diane, Faivre, Emilie, Vandesquille, Matthias, Aron-Badin, Romina, Dhenain, Marc, Déglon, Nicole, Hantraye, Philippe, Brouillet, Emmanuel, Bonvento, Gilles, Escartin, Carole

“…Astrocyte reactivity is a hallmark of neurodegenerative diseases (ND), but its effects on disease outcomes remain highly debated. Elucidation of the signaling…”
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Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates by Gauvain, Gregory, Akolkar, Himanshu, Chaffiol, Antoine, Arcizet, Fabrice, Khoei, Mina A., Desrosiers, Mélissa, Jaillard, Céline, Caplette, Romain, Marre, Olivier, Bertin, Stéphane, Fovet, Claire-Maelle, Demilly, Joanna, Forster, Valérie, Brazhnikova, Elena, Hantraye, Philippe, Pouget, Pierre, Douar, Anne, Pruneau, Didier, Chavas, Joël, Sahel, José-Alain, Dalkara, Deniz, Duebel, Jens, Benosman, Ryad, Picaud, Serge

“…Vision restoration is an ideal medical application for optogenetics, because the eye provides direct optical access to the retina for stimulation. Optogenetic…”
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Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates by Fayard, Audrey, Fenyi, Alexis, Lavisse, Sonia, Dovero, Sandra, Bousset, Luc, Bellande, Tracy, Lecourtois, Sophie, Jouy, Christophe, Guillermier, Martine, Jan, Caroline, Gipchtein, Pauline, Dehay, Benjamin, Bezard, Erwan, Melki, Ronald, Hantraye, Philippe, Aron Badin, Romina

“…The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data…”
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Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates by Goutal, Sébastien, Tournier, Nicolas, Guillermier, Martine, Van Camp, Nadja, Barret, Olivier, Gaudin, Mylène, Bottlaender, Michel, Hantraye, Philippe, Lavisse, Sonia

“…Knowledge of the repeatability of quantitative parameters derived from [18F]FDG PET images is essential to define the group size and allow correct…”
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THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency by Vautheny, Audrey, Duwat, Charlotte, Aurégan, Gwennaëlle, Joséphine, Charlène, Hérard, Anne-Sophie, Jan, Caroline, Mitja, Julien, Gipchtein, Pauline, Gaillard, Marie-Claude, Buée, Luc, Blum, David, Hantraye, Philippe, Bonvento, Gilles, Brouillet, Emmanuel, Cambon, Karine, Bemelmans, Alexis-Pierre

“…The role played by microglia has taken the center of the stage in the etiology of Alzheimer's disease (AD). Several genome-wide association studies carried out…”
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A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin by Damiano, Maria, Diguet, Elsa, Malgorn, Carole, D'Aurelio, Marilena, Galvan, Laurie, Petit, Fanny, Benhaim, Lucile, Guillermier, Martine, Houitte, Diane, Dufour, Noelle, Hantraye, Philippe, Canals, Josep M, Alberch, Jordi, Delzescaux, Thierry, Déglon, Nicole, Beal, M Flint, Brouillet, Emmanuel

“…Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of a CAG repeat encoding a polyglutamine tract in the huntingtin…”
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In vivo evidence for the selective subcortical degeneration in Huntington's disease by Douaud, Gwenaëlle, Behrens, Timothy E., Poupon, Cyril, Cointepas, Yann, Jbabdi, Saâd, Gaura, Véronique, Golestani, Narly, Krystkowiak, Pierre, Verny, Christophe, Damier, Philippe, Bachoud-Lévi, Anne-Catherine, Hantraye, Philippe, Remy, Philippe

“…Although Huntington's disease is largely considered to be a subcortical disease, there is no clear consensus on whether all deep grey matter loss is a direct…”
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Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology by Duwat, Charlotte, Léal, Pauline, Vautheny, Audrey, Aurégan, Gwennaëlle, Joséphine, Charlène, Gaillard, Marie-Claude, Hérard, Anne-Sophie, Jan, Caroline, Gipchtein, Pauline, Mitja, Julien, Fouquet, Stéphane, Niepon, Marie-Laure, Hantraye, Philippe, Brouillet, Emmanuel, Bonvento, Gilles, Cambon, Karine, Bemelmans, Alexis-Pierre

“…Tauopathy is a typical feature of Alzheimer's disease of major importance because it strongly correlates with the severity of cognitive deficits experienced by…”
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Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat by d'Orange, Marie, Aurégan, Gwénaelle, Cheramy, Dimitri, Gaudin-Guérif, Mylène, Lieger, Sarah, Guillermier, Martine, Stimmer, Lev, Joséphine, Charlène, Hérard, Anne-Sophie, Gaillard, Marie-Claude, Petit, Fanny, Kiessling, Maren Christine, Schmitz, Christoph, Colin, Morvane, Buée, Luc, Panayi, Fany, Diguet, Elsa, Brouillet, Emmanuel, Hantraye, Philippe, Bemelmans, Alexis-Pierre, Cambon, Karine

“…The respective contributions of soluble oligomeric tau and neurofibrillary tangles to neurodegeneration remain uncertain. d'Orange et al. generate two rodent…”
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Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies by Dujardin, Simon, Lécolle, Katia, Caillierez, Raphaëlle, Bégard, Séverine, Zommer, Nadège, Lachaud, Cédrick, Carrier, Sébastien, Dufour, Noëlle, Aurégan, Gwennaëlle, Winderickx, Joris, Hantraye, Philippe, Déglon, Nicole, Colin, Morvane, Buée, Luc

“…In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain,…”
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In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin by Kraska, Audrey, Santin, Mathieu D, Dorieux, Olène, Joseph-Mathurin, Nelly, Bourrin, Emmanuel, Petit, Fanny, Jan, Caroline, Chaigneau, Marion, Hantraye, Philippe, Lestage, Pierre, Dhenain, Marc

“…Cerebral aging is often associated with the occurrence of neurodegenerative diseases leading to dementia. Animal models are critical to elucidate mechanisms…”
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The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo by Cresto, Noémie, Gaillard, Marie-Claude, Gardier, Camille, Gubinelli, Francesco, Diguet, Elsa, Bellet, Déborah, Legroux, Laurine, Mitja, Julien, Auregan, Gwenaëlle, Guillermier, Martine, Josephine, Charlène, Jan, Caroline, Dufour, Noëlle, Joliot, Alain, Hantraye, Philippe, Bonvento, Gilles, Déglon, Nicole, Bemelmans, Alexis-Pierre, Cambon, Karine, Liot, Géraldine, Brouillet, Emmanuel

“…The G2019S substitution in the kinase domain of LRRK2 (LRRK2G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects…”
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Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque by Comoy, Emmanuel E., Mikol, Jacqueline, Jaffré, Nina, Lebon, Vincent, Levavasseur, Etienne, Streichenberger, Nathalie, Sumian, Chryslain, Perret-Liaudet, Armand, Eloit, Marc, Andreoletti, Olivier, Haïk, Stéphane, Hantraye, Philippe, Deslys, Jean-Philippe

“…Exposure of human populations to bovine spongiform encephalopathy through contaminated food has resulted in <250 cases of variant Creutzfeldt–Jakob disease…”
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miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions by Orefice, Nicola S, Guillemot-Legris, Owein, Capasso, Rosanna, Bottemanne, Pauline, Hantraye, Philippe, Caraglia, Michele, Orefice, Giuseppe, Alhouayek, Mireille, Muccioli, Giulio G

“…Cortical lesions represent a hallmark of multiple sclerosis and are proposed as a predictor of disease severity. microRNAs are suggested to be important…”
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