Search Results - "HANSEN, J. Bondo"

NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels by Huang, Luping, Keyser, Brian M, Tagmose, Tina M, Hansen, J Bondo, Taylor, James T, Zhuang, Hean, Zhang, Min, Ragsdale, David S, Li, Ming

“…Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca2+ channels. We previously showed that block of…”
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Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders by Hansen, J Bondo, Arkhammar, Per O G, Bodvarsdottir, Thora B, Wahl, Philip

“…The pattern of insulin release is crucial for regulation of glucose and lipid haemostasis. Deficient insulin release causes hyperglycemia and diabetes, whereas…”
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New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells by Nielsen, Flemming E, Ebdrup, Søren, Jensen, Anette Frost, Ynddal, Lars, Bodvarsdottir, Thora B, Stidsen, Carsten, Worsaae, Anne, Boonen, Harrie C. M, Arkhammar, Per O. G, Fremming, Tinna, Wahl, Philip, Kornø, Hanne T, Hansen, J. Bondo

“…Compound 1a (NN414) is a potent opener of Kir6.2/SUR1 K ATP channels. Compound 1a inhibits insulin release in vitro and in vivo and preserves beta cell…”
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Openers of ATP-dependent K+-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetes by BJÖRKLUND, A, HANSEN, J. Bondo, FALKMER, S, GRILL, V

“…We tested whether chronic overstimulation by levels of hyperglycaemia commonly found in Type 2 diabetes can irreversibly desensitise beta cells and, if so,…”
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A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release by LEBRUN, P, ARKHAMMAR, P, ANTOINE, M.-H, NGUYEN, Q.-A, HANSEN, J. B, PIROTTE, B

“…To characterise the effects of BPDZ 73 (7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide), a newly synthesised diazoxide analogue, on insulin…”
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Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation by Taylor, James T, Huang, Luping, Pottle, Jonathan E, Liu, Kai, Yang, Yali, Zeng, Xiangbin, Keyser, Brian M, Agrawal, Krishna C, Hansen, J. Bondo, Li, Ming

“…Abstract We have measured the expression of T-type Ca2+ channel mRNA in breast cancer cell lines (MCF-7 (ERα+) using Western blot and quantitative real-time…”
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6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells by Nielsen, Flemming E, Bodvarsdottir, Thora B, Worsaae, Anne, MacKay, Peter, Stidsen, Carsten E, Boonen, Harrie C. M, Pridal, Lone, Arkhammar, Per O. G, Wahl, Philip, Ynddal, Lars, Junager, Finn, Dragsted, Nils, Tagmose, Tina M, Mogensen, John P, Koch, Anette, Treppendahl, Svend P, Hansen, J. Bondo

“…6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives were synthesized and characterized as activators of adenosine 5‘-triphosphate…”
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Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1β mediated suppression: possible involvement of the mitochondrial membrane potential by KULLIN, M, LI, Z, HANSEN, J. Bondo, WELSH, N, KARLSSON, F. A, SANDLER, S

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Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396 by Li, Ming, Hansen, J Bondo, Huang, Luping, Keyser, Brian M, Taylor, James T

“…NNC 55-0396 is a structural analog of mibefradil (Ro 40-5967) that inhibits both T-type and high-voltage-activated (HVA) Ca2+ channels with a higher…”
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Potent and selective activation of the pancreatic beta-cell type KATP channel by two novel diazoxide analogues by DABROWSKI, M, LARSEN, T, ASHCROFT, F. M, HANSEN, J. Bondo, WAHL, P

“…We investigated the pharmacological properties of two novel ATP sensitive potassium (K(ATP)) channel openers, 6-Chloro-3-isopropylamino-4 H-thieno[3,2-…”
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Alkoxyfurocoumarin derivatives as potential mesolimbic selective antipsychotics by Bondo Hansen, J, Fink-Jensen, A, Hansen, L, Nielsen, EB, Scheideler, MA

“…A series of potential antipsychotic compounds have been synthesized by combining a furocoumarin heterocycle through a linker of different sizes with an…”
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Potent and selective activation of the pancreatic beta-cell type K ATP channel by two novel diazoxide analogues by Dabrowski, M., Larsen, T., Ashcroft, F. M., Bondo Hansen, J., Wahl, P.

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Selective blockade of T-type Ca 2+ channels suppresses human breast cancer cell proliferation by Taylor, James T., Huang, Luping, Pottle, Jonathan E., Liu, Kai, Yang, Yali, Zeng, Xiangbin, Keyser, Brian M., Agrawal, Krishna C., Hansen, J. Bondo, Li, Ming

“…We have measured the expression of T-type Ca 2+ channel mRNA in breast cancer cell lines (MCF-7 (ERα+) using Western blot and quantitative real-time PCR…”
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New 3-Alkylamino-4 H -thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells by Nielsen, Flemming E., Ebdrup, Søren, Jensen, Anette Frost, Ynddal, Lars, Bodvarsdottir, Thora B., Stidsen, Carsten, Worsaae, Anne, Boonen, Harrie C. M., Arkhammar, Per O. G., Fremming, Tinna, Wahl, Philip, Kornø, Hanne T., Hansen, J. Bondo

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Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues by Dabrowski, M, Larsen, T, Ashcroft, F M, Bondo Hansen, J, Wahl, P

“…We investigated the pharmacological properties of two novel ATP sensitive potassium (K(ATP)) channel openers, 6-Chloro-3-isopropylamino-4 H-thieno[3,2-…”
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Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential by Kullin, M, Li, Z, Bondo Hansen, J, Welsh, N, Karlsson, F A, Sandler, S

“…We aimed to study the effects of two K(ATP) channel openers (KCO), diazoxide and the more potent compound NNC 55-0118, on beta-cell suppression and/or toxicity…”
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Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1[beta] mediated suppression--possible involvement of the mitochondrial membrane potential by Kullin, M, Z. Li, Hansen, J Bondo, Welsh, N, Karlsson, F A, Sandler, S

“…Aims/hypothesis. We aimed to study the effects of two KATP channel openers (KCO), diazoxide and the more potent compound NNC 55-0118, on beta-cell suppression…”
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6-Chloro-3-alkylamino-4 H -thieno[3,2 -e ]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells by Nielsen, Flemming E., Bodvarsdottir, Thora B., Worsaae, Anne, MacKay, Peter, Stidsen, Carsten E., Boonen, Harrie C. M., Pridal, Lone, Arkhammar, Per O. G., Wahl, Philip, Ynddal, Lars, Junager, Finn, Dragsted, Nils, Tagmose, Tina M., Mogensen, John P., Koch, Anette, Treppendahl, Svend P., Hansen, J. Bondo

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Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells by Tagmose, Tina M, Mogensen, John P, Agerholm, Pia C, Arkhammar, Per O.G, Wahl, Philip, Worsaae, Anne, Hansen, J.Bondo

“…3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from…”
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Two polymorphs - which one is stable at ambient conditions? by Jensen, A. F., Junager, F., Laustsen, S. B., Rasmussen, P., Jessen, C. U., Kornø, H. T., Bondo Hansen, J.

“…Abstract only…”
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