Search Results - "HANSEN, HENRIK H."

Mouse models of nonalcoholic steatohepatitis in preclinical drug development by Hansen, Henrik H., Feigh, Michael, Veidal, Sanne S., Rigbolt, Kristoffer T., Vrang, Niels, Fosgerau, Keld

“…•Non-alcoholic steatohepatitis (NASH) is a medical disease of unmet therapeutic need.•Numerous drugs are in various stages of clinical development for…”
Get full text

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice by Madsen, Mette Simone Aae, Holm, Jacob Bak, Pallejà, Albert, Wismann, Pernille, Fabricius, Katrine, Rigbolt, Kristoffer, Mikkelsen, Martin, Sommer, Morten, Jelsing, Jacob, Nielsen, Henrik Bjørn, Vrang, Niels, Hansen, Henrik H.

“…Enteroendocrine L-cell derived peptide hormones, notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), have become important targets in…”
Get full text

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis by Tølbøl, Kirstine S, Kristiansen, Maria Nb, Hansen, Henrik H, Veidal, Sanne S, Rigbolt, Kristoffer Tg, Gillum, Matthew P, Jelsing, Jacob, Vrang, Niels, Feigh, Michael

“…To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis (NASH) in obese mouse models of biopsy-confirmed NASH…”
Get full text

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy by Hansen, Henrik H, Barkholt, Pernille, Fabricius, Katrine, Jelsing, Jacob, Terwel, Dick, Pyke, Charles, Knudsen, Lotte Bjerre, Vrang, Niels

“…Abstract In addition to a prominent role in glycemic control, glucagon-like peptide 1 (GLP-1) receptor agonists exhibit neuroprotective properties. There is…”
Get full text

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease by Hansen, Henrik H, Fabricius, Katrine, Barkholt, Pernille, Niehoff, Michael L, Morley, John E, Jelsing, Jacob, Pyke, Charles, Knudsen, Lotte Bjerre, Farr, Susan A, Vrang, Niels

“…Recent studies indicate that glucagon-like peptide 1 (GLP-1) receptor agonists, currently used in the management of type 2 diabetes, exhibit neurotrophic and…”
Get more information

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source by Boland, Michelle L, Oró, Denise, Tølbøl, Kirstine S, Thrane, Sebastian T, Nielsen, Jens Christian, Cohen, Taylor S, Tabor, David E, Fernandes, Fiona, Tovchigrechko, Andrey, Veidal, Sanne S, Warrener, Paul, Sellman, Bret R, Jelsing, Jacob, Feigh, Michael, Vrang, Niels, Trevaskis, James L, Hansen, Henrik H

“…The trans-fat containing AMLN (amylin liver non-alcoholic steatohepatitis, NASH) diet has been extensively validated in C57BL/6J mice with or without the Lep…”
Get full text

Semaglutide reduces tumor burden in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH-HCC with advanced fibrosis by Hansen, Henrik H., Pors, Susanne, Andersen, Maja W., Vyberg, Mogens, Nøhr-Meldgaard, Jacob, Nielsen, Malte Hasle, Oró, Denise, Madsen, Martin Rønn, Lewinska, Monika, Møllerhøj, Mathias B., Madsen, Andreas Nygaard, Feigh, Michael

“…Non-alcoholic steatohepatitis (NASH) is emerging as a major cause of hepatocellular carcinoma (HCC), however, it is not resolved if compounds in late-stage…”
Get full text

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis by Hansen, Henrik H, Ægidius, Helene M, Oró, Denise, Evers, Simon S, Heebøll, Sara, Eriksen, Peter Lykke, Thomsen, Karen Louise, Bengtsson, Anja, Veidal, Sanne S, Feigh, Michel, Suppli, Malte P, Knop, Filip K, Grønbæk, Henning, Miranda, Diego, Trevaskis, James L, Vrang, Niels, Jelsing, Jacob, Rigbolt, Kristoffer T G

“…Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced…”
Get full text

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease by Hansen, Henrik H, Fabricius, Katrine, Barkholt, Pernille, Kongsbak-Wismann, Pernille, Schlumberger, Chantal, Jelsing, Jacob, Terwel, Dick, Termont, Annelies, Pyke, Charles, Knudsen, Lotte Bjerre, Vrang, Niels

“…One of the major histopathological hallmarks of Alzheimer's disease (AD) is cerebral deposits of extracellular β-amyloid peptides. Preclinical studies have…”
Get full text

Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH by Møllerhøj, Mathias B., Veidal, Sanne S., Thrane, Kirstine Tølbøl, Oró, Denise, Overgaard, Agnete, Salinas, Casper Gravesen, Madsen, Martin Rønn, Pfisterer, Larissa, Vyberg, Mogens, Simon, Eric, Broermann, Andre, Vrang, Niels, Jelsing, Jacob, Feigh, Michael, Hansen, Henrik H.

“…Non‐alcoholic steatohepatitis (NASH) has emerged as a major challenge for public health because of high global prevalence and lack of evidence‐based therapies…”
Get full text

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice by Hansen, Henrik H., Grønlund, Rikke V., Baader-Pagler, Tamara, Haebel, Peter, Tammen, Harald, Larsen, Leif Kongskov, Jelsing, Jacob, Vrang, Niels, Klein, Thomas

“…Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1…”
Get full text

Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice by Madsen, Mette Simone Aae, Grønlund, Rikke Veggerby, Eid, John, Christensen-Dalsgaard, Mikkel, Sommer, Morten, Rigbolt, Kristoffer, Madsen, Martin Rønn, Jelsing, Jacob, Vrang, Niels, Hansen, Henrik H., Mikkelsen, Martin

“…[Display omitted] •Paired analysis of gut segmental bacterial composition and host gene expression was performed in rosiglitazone-treated diabetic db/db…”
Get full text

Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH by Flensted-Jensen, Mathias, Oró, Denise, Rørbeck, Emma A, Zhang, Chen, Madsen, Martin Rønn, Madsen, Andreas Nygaard, Norlin, Jenny, Feigh, Michael, Larsen, Steen, Hansen, Henrik H

“…Hepatocellular senescence may be a causal factor in the development and progression of non-alcoholic steatohepatitis (NASH). The most effective currently…”
Get full text

Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment by Hagemann, Christoffer A, Zhang, Chen, Hansen, Henrik H, Jorsal, Tina, Rigbolt, Kristoffer T G, Madsen, Martin R, Bergmann, Natasha C, Heimbürger, Sebastian M N, Falkenhahn, Mechthilde, Theis, Stefan, Breitschopf, Kristin, Holm, Stephanie, Hedegaard, Morten A, Christensen, Mikkel B, Vilsbøll, Tina, Holst, Birgitte, Vrang, Niels, Jelsing, Jacob, Knop, Filip K

“…Abstract Context The mechanisms underlying Roux-en-Y gastric bypass (RYGB) surgery-induced weight loss and the immediate postoperative beneficial metabolic…”
Get full text

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat by Hansen, Henrik H., Hansen, Gitte, Paulsen, Sarah, Vrang, Niels, Mark, Michael, Jelsing, Jacob, Klein, Thomas

“…Linagliptin is a dipeptidyl peptidase (DPP)-IV inhibitor approved for the treatment of type 2 diabetes. DPP-IV inhibitors are considered weight neutral,…”
Get full text

Whole-brain activation signatures of weight-lowering drugs by Hansen, Henrik H., Perens, Johanna, Roostalu, Urmas, Skytte, Jacob Lercke, Salinas, Casper Gravesen, Barkholt, Pernille, Thorbek, Ditte Dencker, Rigbolt, Kristoffer T.G., Vrang, Niels, Jelsing, Jacob, Hecksher-Sørensen, Jacob

“…The development of effective anti-obesity therapeutics relies heavily on the ability to target specific brain homeostatic and hedonic mechanisms controlling…”
Get full text

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect by Alexopoulou, Flora, Bech, Esben Matzen, Pedersen, Søren Ljungberg, Thorbek, Ditte Dencker, Leurs, Ulrike, Rudkjær, Lise Christine Biehl, Fosgerau, Keld, Hansen, Henrik H., Vrang, Niels, Jelsing, Jacob, Elster, Lisbeth

“…Prolactin-releasing peptide (PrRP) is an endogenous neuropeptide involved in appetite regulation and energy homeostasis. PrRP binds with high affinity to…”
Get full text

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease by Roostalu, Urmas, Salinas, Casper B G, Thorbek, Ditte D, Skytte, Jacob L, Fabricius, Katrine, Barkholt, Pernille, John, Linu M, Jurtz, Vanessa Isabell, Knudsen, Lotte Bjerre, Jelsing, Jacob, Vrang, Niels, Hansen, Henrik H, Hecksher-Sørensen, Jacob

“…Parkinson's disease (PD) is a basal ganglia movement disorder characterized by progressive degeneration of the nigrostriatal dopaminergic system…”
Get full text

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography by Roostalu, Urmas, Thisted, Louise, Skytte, Jacob Lercke, Salinas, Casper Gravesen, Pedersen, Philip Juhl, Hecksher-Sørensen, Jacob, Rolin, Bidda, Hansen, Henrik H., MacKrell, James G., Christie, Robert M., Vrang, Niels, Jelsing, Jacob, Zois, Nora Elisabeth

“…Angiotensin converting enzyme inhibitors, among them captopril, improve survival following myocardial infarction (MI). The mechanisms of captopril action…”
Get full text

Whole-brain three-dimensional imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases by Hansen, Henrik, Roostalu, Urmas, Hecksher-Sørensen, Jacob

“…In preclinical PD research, animal model development has centered around recapitulating progressive dopaminergic neuronal loss in the nigrostriatal system…”
Get full text