Search Results - "HANNIFORD, Douglas"

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor by Segura, Miguel F, Hanniford, Douglas, Menendez, Silvia, Reavie, Linsey, Zou, Xuanyi, Alvarez-Diaz, Silvia, Zakrzewski, Jan, Blochin, Elen, Rose, Amy, Bogunovic, Dusan, Polsky, David, Wei, Jianjun, Lee, Peng, Belitskaya-Levy, Ilana, Bhardwaj, Nina, Osman, Iman, Hernando, Eva

“…The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most…”
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miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis by Gaziel-Sovran, Avital, Segura, Miguel F., Di Micco, Raffaella, Collins, Mary K., Hanniford, Douglas, Vega-Saenz de Miera, Eleazar, Rakus, John F., Dankert, John F., Shang, Shulian, Kerbel, Robert S., Bhardwaj, Nina, Shao, Yongzhao, Darvishian, Farbod, Zavadil, Jiri, Erlebacher, Adrian, Mahal, Lara K., Osman, Iman, Hernando, Eva

“…To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that…”
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Melanoma MicroRNA Signature Predicts Post-Recurrence Survival by SEGURA, Miguel F, BELITSKAYA-LEVY, Ilana, OSMAN, Iman, HERNANDO, Eva, ROSE, Amy E, ZAKRZEWSKI, Jan, GAZIEL, Avital, HANNIFORD, Douglas, DARVISHIAN, Farbod, BERMAN, Russell S, SHAPIRO, Richard L, PAVLICK, Anna C

“…To identify a melanoma microRNA (miRNA) expression signature that is predictive of outcome and then evaluate its potential to improve risk stratification when…”
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MicroRNA‐125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway by Koetz‐Ploch, Lisa, Hanniford, Douglas, Dolgalev, Igor, Sokolova, Elena, Zhong, Judy, Díaz‐Martínez, Marta, Bernstein, Emily, Darvishian, Farbod, Flaherty, Keith T., Chapman, Paul B., Tawbi, Hussein, Hernando, Eva

“…Summary Melanoma patients with BRAFV600E‐mutant tumors display striking responses to BRAF inhibitors (BRAFi); however, almost all invariably relapse with…”
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis by Hanniford, Douglas, Ulloa-Morales, Alejandro, Karz, Alcida, Berzoti-Coelho, Maria Gabriela, Moubarak, Rana S., Sánchez-Sendra, Beatriz, Kloetgen, Andreas, Davalos, Veronica, Imig, Jochen, Wu, Pamela, Vasudevaraja, Varshini, Argibay, Diana, Lilja, Karin, Tabaglio, Tommaso, Monteagudo, Carlos, Guccione, Ernesto, Tsirigos, Aristotelis, Osman, Iman, Aifantis, Iannis, Hernando, Eva

“…Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metastatic spread may uncover important tumor biology and/or yield…”
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Revisiting determinants of prognosis in cutaneous melanoma by Weiss, Sarah A., Hanniford, Douglas, Hernando, Eva, Osman, Iman

“…The American Joint Committee on Cancer staging system for cutaneous melanoma is based on primary tumor thickness and the presence of ulceration, mitoses, lymph…”
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circSamd4 represses myogenic transcriptional activity of PUR proteins by Pandey, Poonam R, Yang, Jen-Hao, Tsitsipatis, Dimitrios, Panda, Amaresh C, Noh, Ji Heon, Kim, Kyoung Mi, Munk, Rachel, Nicholson, Thomas, Hanniford, Douglas, Argibay, Diana, Yang, Xiaoling, Martindale, Jennifer L, Chang, Ming-Wen, Jones, Simon W, Hernando, Eva, Sen, Payel, De, Supriyo, Abdelmohsen, Kotb, Gorospe, Myriam

“…Abstract By interacting with proteins and nucleic acids, the vast family of mammalian circRNAs is proposed to influence many biological processes. Here, RNA…”
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The State of Melanoma: Emergent Challenges and Opportunities by Atkins, Michael B, Curiel-Lewandrowski, Clara, Fisher, David E, Swetter, Susan M, Tsao, Hensin, Aguirre-Ghiso, Julio A, Soengas, Maria S, Weeraratna, Ashani T, Flaherty, Keith T, Herlyn, Meenhard, Sosman, Jeffrey A, Tawbi, Hussein A, Pavlick, Anna C, Cassidy, Pamela B, Chandra, Sunandana, Chapman, Paul B, Daud, Adil, Eroglu, Zeynep, Ferris, Laura K, Fox, Bernard A, Gershenwald, Jeffrey E, Gibney, Geoffrey T, Grossman, Douglas, Hanks, Brent A, Hanniford, Douglas, Hernando, Eva, Jeter, Joanne M, Johnson, Douglas B, Khleif, Samir N, Kirkwood, John M, Leachman, Sancy A, Mays, Darren, Nelson, Kelly C, Sondak, Vernon K, Sullivan, Ryan J, Merlino, Glenn

“…Five years ago, the Melanoma Research Foundation (MRF) conducted an assessment of the challenges and opportunities facing the melanoma research community and…”
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A TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy by Martinez-Ruiz, Haydeliz, Illa-Bochaca, Irineu, Omene, Coral, Hanniford, Douglas, Liu, Qi, Hernando, Eva, Barcellos-Hoff, Mary Helen

“…Maintenance of mammary functional capacity during cycles of proliferation and regression depends on appropriate cell fate decisions of mammary progenitor cells…”
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Revisiting determinants of prognosis in cutanous melanoma by Weiss, Sarah, Hanniford, Douglas, Hernando, Eva, Osman, Iman

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BET and BRAF inhibitors act synergistically against BRAF‐mutant melanoma by Paoluzzi, Luca, Hanniford, Douglas, Sokolova, Elena, Osman, Iman, Darvishian, Farbod, Wang, Jinhua, Bradner, James E., Hernando, Eva

“…Despite major advances in the treatment of metastatic melanoma, treatment failure is still inevitable in most cases. Manipulation of key epigenetic regulators,…”
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Functional analysis of RPS27 mutations and expression in melanoma by Floristán, Alfredo, Morales, Leah, Hanniford, Douglas, Martinez, Carlos, Castellano‐Sanz, Elena, Dolgalev, Igor, Ulloa‐Morales, Alejandro, Vega‐Saenz de Miera, Eleazar, Moran, Una, Darvishian, Farbod, Osman, Iman, Kirchhoff, Tomas, Hernando, Eva

“…Next‐generation sequencing has enabled genetic and genomic characterization of melanoma to an unprecedent depth. However, the high mutational background plus…”
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Abstract PR04: Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis by Hanniford, Douglas, Ulloa-Morales, Alejandro, Sánchez-Sendra, Beatriz, Karz, Alcida, Moubarak, Rana, Tabaglio, Tommaso, Berzoti-Coelho, Maria Gabriela, Davalos, Veronica, Wu, Pamela, Vasudevaraja, Varshini, Kloetgen, Andreas, Lilja, Karin, Imig, Jochen, Monteagudo, Carlos, Guccione, Ernesto, Tsirigos, Aristotelis, Osman, Iman, Aifantis, Iannis, Hernando, Eva

“…Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metastatic spread may uncover new biology and/or yield promising…”
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Mutation burden as a potential prognostic marker of melanoma progression and survival by Simpson, Danny, Ferguson, Robert, Martinez, Carlos N., Kazlow, Esther, Moran, Una, Heguy, Adriana, Hanniford, Douglas, Hernando, Eva, Osman, Iman, Kirchhoff, Tomas

“…Abstract only 9567 Background: Recently, tumor mutation burden (TMB) has been shown to increase the presentation of neoantigens that stimulate immune tumor…”
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Abstract 3522: BET and BRAF inhibitors act synergistically against BRAF mutant melanoma by Paoluzzi, Luca, Hanniford, Douglas, Sokolova, Elena, Osman, Iman, Darvishian, Farbod, Wang, Jinhua, Bradner, James E., Hernando, Eva

“…Purpose: Despite major advances in the treatment of metastatic melanoma, treatment failure is still inevitable in most cases. Manipulation of key epigenetic…”
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Histology-Specific MicroRNA Alterations in Melanoma by Poliseno, Laura, Haimovic, Adele, Segura, Miguel F., Hanniford, Douglas, Christos, Paul J., Darvishian, Farbod, Wang, Jinhua, Shapiro, Richard L., Pavlick, Anna C., Berman, Russell S., Hernando, Eva, Zavadil, Jiri, Osman, Iman

“…We examined the microRNA signature that distinguishes the most common melanoma histological subtypes, superficial spreading melanoma (SSM) and nodular melanoma…”
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Micro RNA ‐125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway by Koetz‐Ploch, Lisa, Hanniford, Douglas, Dolgalev, Igor, Sokolova, Elena, Zhong, Judy, Díaz‐Martínez, Marta, Bernstein, Emily, Darvishian, Farbod, Flaherty, Keith T., Chapman, Paul B., Tawbi, Hussein, Hernando, Eva

“…Melanoma patients with BRAF V 600E ‐ mutant tumors display striking responses to BRAF inhibitors ( BRAF i); however, almost all invariably relapse with…”
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Melanoma recurrence risk stratification using Bayesian systems biology modeling by Styrmisdottir, Edda Lind, Scanlon, Patrick, Hanniford, Douglas, Eberhardt, John, Jones, Thomas, Hernando, Eva, Osman, Iman

“…Abstract only 9089 Background: Estimating the risk of recurrence in patients with melanoma is extremely challenging. Standard of care is AJCC staging system,…”
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Preclinical testing supports combined BET and BRAF inhibition as a promising therapeutic strategy for melanoma by Paoluzzi, Luca, Hanniford, Douglas, Sokolova, Elena, Dolgalev, Igor, Heguy, Adriana, Osman, Iman, Darvishian, Farbod, Wang, Jinhua, Bradner, James E., Hernando, Eva

“…Abstract only…”
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Clinical relevance of SKP2 alterations in metastatic melanoma by Rose, Amy E., Wang, Guimin, Hanniford, Douglas, Monni, Stefano, Tu, Ting, Shapiro, Richard L., Berman, Russell S., Pavlick, Anna C., Pagano, Michele, Darvishian, Farbod, Mazumdar, Madhu, Hernando, Eva, Osman, Iman

“…Summary In this study, we investigated the mechanism(s) of altered expression of protooncogene SKP2 in metastatic melanoma and its clinical relevance in…”
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