Search Results - "HANLEY, Neil A"

Human pancreas development by Jennings, Rachel E, Berry, Andrew A, Strutt, James P, Gerrard, David T, Hanley, Neil A

“…A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic…”
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Hospital length of stay for COVID-19 patients: Data-driven methods for forward planning by Vekaria, Bindu, Overton, Christopher, WiÅniowski, Arkadiusz, Ahmad, Shazaad, Aparicio-Castro, Andrea, Curran-Sebastian, Jacob, Eddleston, Jane, Hanley, Neil A, House, Thomas, Kim, Jihye, Olsen, Wendy, Pampaka, Maria, Pellis, Lorenzo, Ruiz, Diego Perez, Schofield, John, Shryane, Nick, Elliot, Mark J

“…Predicting hospital length of stay (LoS) for patients with COVID-19 infection is essential to ensure that adequate bed capacity can be provided without…”
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Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture by Gieseck, 3rd, Richard L, Hannan, Nicholas R F, Bort, Roque, Hanley, Neil A, Drake, Rosemary A L, Cameron, Grant W W, Wynn, Thomas A, Vallier, Ludovic

“…Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce the demand for a dwindling number of primary cells used in…”
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PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis by Martin, Katherine, Pritchett, James, Llewellyn, Jessica, Mullan, Aoibheann F., Athwal, Varinder S., Dobie, Ross, Harvey, Emma, Zeef, Leo, Farrow, Stuart, Streuli, Charles, Henderson, Neil C., Friedman, Scott L., Hanley, Neil A., Piper Hanley, Karen

“…Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure…”
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Development of the Human Pancreas From Foregut to Endocrine Commitment by JENNINGS, Rachel E, BERRY, Andrew A, KIRKWOOD-WILSON, Rebecca, ROBERTS, Neil A, HEARN, Thomas, SALISBURY, Rachel J, BLAYLOCK, Jennifer, HANLEY, Karen Piper, HANLEY, Neil A

“…Knowledge of human pancreas development underpins our interpretation and exploitation of human pluripotent stem cell (PSC) differentiation toward a β-cell…”
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Alternative pathway androgen biosynthesis and human fetal female virilization by Reisch, Nicole, Taylor, Angela E., Nogueira, Edson F., Asby, Daniel J., Dhir, Vivek, Berry, Andrew, Krone, Nils, Auchus, Richard J., Shackleton, Cedric H. L., Hanley, Neil A., Arlt, Wiebke

“…Androgen biosynthesis in the human fetus proceeds through the adrenal sex steroid precursor dehydroepiandrosterone, which is converted to testosterone in the…”
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TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors by Cebola, Inês, Rodríguez-Seguí, Santiago A., Cho, Candy H-H., Bessa, José, Rovira, Meritxell, Luengo, Mario, Chhatriwala, Mariya, Berry, Andrew, Ponsa-Cobas, Joan, Maestro, Miguel Angel, Jennings, Rachel E., Pasquali, Lorenzo, Morán, Ignasi, Castro, Natalia, Hanley, Neil A., Gomez-Skarmeta, Jose Luis, Vallier, Ludovic, Ferrer, Jorge

“…The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for…”
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Assessing the Safety of Stem Cell Therapeutics by Goldring, Chris E.P., Duffy, Paul A., Benvenisty, Nissim, Andrews, Peter W., Ben-David, Uri, Eakins, Rowena, French, Neil, Hanley, Neil A., Kelly, Lorna, Kitteringham, Neil R., Kurth, Jens, Ladenheim, Deborah, Laverty, Hugh, McBlane, James, Narayanan, Gopalan, Patel, Sara, Reinhardt, Jens, Rossi, Annamaria, Sharpe, Michaela, Park, B. Kevin

“…Unprecedented developments in stem cell research herald a new era of hope and expectation for novel therapies. However, they also present a major challenge for…”
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Understanding the role of SOX9 in acquired diseases: lessons from development by Pritchett, James, Athwal, Varinder, Roberts, Neil, Hanley, Neil A, Hanley, Karen Piper

“…The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder…”
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Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions by Forristal, Catherine E, Wright, Kate L, Hanley, Neil A, Oreffo, Richard O C, Houghton, Franchesca D

“…Human embryonic stem (hES) cells are routinely cultured under atmospheric, 20% oxygen tensions but are derived from embryos which reside in a 3–5% oxygen…”
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Perrault Syndrome Is Caused by Recessive Mutations in CLPP, Encoding a Mitochondrial ATP-Dependent Chambered Protease by Jenkinson, Emma M., Rehman, Atteeq U., Walsh, Tom, Clayton-Smith, Jill, Lee, Kwanghyuk, Morell, Robert J., Drummond, Meghan C., Khan, Shaheen N., Naeem, Muhammad Asif, Rauf, Bushra, Billington, Neil, Schultz, Julie M., Urquhart, Jill E., Lee, Ming K., Berry, Andrew, Hanley, Neil A., Mehta, Sarju, Cilliers, Deirdre, Clayton, Peter E., Kingston, Helen, Smith, Miriam J., Warner, Thomas T., Black, Graeme C., Trump, Dorothy, Davis, Julian R.E., Ahmad, Wasim, Leal, Suzanne M., Riazuddin, Sheikh, King, Mary-Claire, Friedman, Thomas B., Newman, William G.

“…Perrault syndrome is a genetically and clinically heterogeneous autosomal-recessive condition characterized by sensorineural hearing loss and ovarian failure…”
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PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis by Jokl, Elliot, Mullan, Aoibheann F., Simpson, Kara, Birchall, Lindsay, Pearmain, Laurence, Martin, Katherine, Pritchett, James, Raza, Sayyid, Shah, Rajesh, Hodson, Nigel W., Williams, Craig J., Camacho, Elizabeth, Zeef, Leo, Donaldson, Ian, Athwal, Varinder S., Hanley, Neil A., Piper Hanley, Karen

“…Myofibroblasts are responsible for scarring during fibrosis. The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell…”
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An integrative transcriptomic atlas of organogenesis in human embryos by Gerrard, Dave T, Berry, Andrew A, Jennings, Rachel E, Piper Hanley, Karen, Bobola, Nicoletta, Hanley, Neil A

“…Human organogenesis is when severe developmental abnormalities commonly originate. However, understanding this critical embryonic phase has relied upon…”
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A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology by Birket, Matthew J., Raibaud, Sophie, Lettieri, Miriam, Adamson, Antony D., Letang, Valerie, Cervello, Pauline, Redon, Nicolas, Ret, Gwenaelle, Viale, Sandra, Wang, Bing, Biton, Bruno, Guillemot, Jean-Claude, Mikol, Vincent, Leonard, John P., Hanley, Neil A., Orsini, Cecile, Itier, Jean-Michel

“…Here, we have used patient-derived induced pluripotent stem cell (iPSC) and gene-editing technology to study the cardiac-related molecular and functional…”
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Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders by Gerrard, Dave T., Berry, Andrew A., Jennings, Rachel E., Birket, Matthew J., Zarrineh, Peyman, Garstang, Myles G., Withey, Sarah L., Short, Patrick, Jiménez-Gancedo, Sandra, Firbas, Panos N., Donaldson, Ian, Sharrocks, Andrew D., Hanley, Karen Piper, Hurles, Matthew E., Gomez-Skarmeta, José Luis, Bobola, Nicoletta, Hanley, Neil A.

“…How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark…”
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Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731 by Knorz, Victoria J, Spalluto, Cosma, Lessard, Mark, Purvis, Tracey L, Adigun, Fiona F, Collin, Gayle B, Hanley, Neil A, Wilson, David I, Hearn, Thomas

“…Mutations in the human gene ALMS1 cause Alström syndrome, a rare progressive condition characterized by neurosensory degeneration and metabolic defects. ALMS1…”
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Generation of Multipotent Foregut Stem Cells from Human Pluripotent Stem Cells by Hannan, Nicholas R.F., Fordham, Robert P., Syed, Yasir A., Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A., Jensen, Kim B., Vallier, Ludovic

“…Human pluripotent stem cells (hPSCs) could provide an infinite source of clinically relevant cells with potential applications in regenerative medicine…”
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SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis by Athwal, Varinder S, Pritchett, James, Llewellyn, Jessica, Martin, Katherine, Camacho, Elizabeth, Raza, Sayyid MA, Phythian‐Adams, Alexander, Birchall, Lindsay J, Mullan, Aoibheann F, Su, Kim, Pearmain, Laurence, Dolman, Grace, Zaitoun, Abed M, Friedman, Scott L, MacDonald, Andrew, Irving, William L, Guha, Indra N, Hanley, Neil A, Piper Hanley, Karen

“…Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis…”
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Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells by Pritchett, James, Athwal, Varinder S, Harvey, Emma, Martin, Katherine, Llewellyn, Jessica, Ireland, Philip, Nicolaides, Alexander, Humphries, Martin J, Bobola, Nicoletta, Hanley, Neil A, Piper Hanley, Karen

“…Liver fibrosis is a major cause of morbidity and mortality. It is characterised by excessive extracellular matrix (ECM) deposition from activated hepatic…”
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Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome by Weber, Stefanie, Thiele, Holger, Mir, Sevgi, Toliat, Mohammad Reza, Sozeri, Betül, Reutter, Heiko, Draaken, Markus, Ludwig, Michael, Altmüller, Janine, Frommolt, Peter, Stuart, Helen M., Ranjzad, Parisa, Hanley, Neil A., Jennings, Rachel, Newman, William G., Wilcox, Duncan T., Thiel, Uwe, Schlingmann, Karl Peter, Beetz, Rolf, Hoyer, Peter F., Konrad, Martin, Schaefer, Franz, Nürnberg, Peter, Woolf, Adrian S.

“…Urinary bladder malformations associated with bladder outlet obstruction are a frequent cause of progressive renal failure in children. We here describe a…”
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