Search Results - "HANEMAAIJER, Roeland"

Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction by González-Santamaría, José, Villalba, María, Busnadiego, Oscar, López-Olañeta, Marina M, Sandoval, Pilar, Snabel, Jessica, López-Cabrera, Manuel, Erler, Janine T, Hanemaaijer, Roeland, Lara-Pezzi, Enrique, Rodríguez-Pascual, Fernando

“…After myocardial infarction (MI), extensive remodelling of the extracellular matrix contributes to scar formation. While aiming to preserve tissue integrity,…”
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The pathophysiology of abdominal aortic aneurysm growth: Corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms by Abdul-Hussien, Hazem, MD, Hanemaaijer, Roeland, PhD, Kleemann, Robert, PhD, Verhaaren, Ben F.J., Bsc, van Bockel, J. Hajo, MD, PhD, Lindeman, Jan H.N., MD, PhD

“…Objective There is remarkable controversy over the processes driving abdominal aneurysm growth. The inherent limitations of animal and human studies hamper…”
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Identifying patient subgroups in MASLD and MASH-associated fibrosis: molecular profiles and implications for drug development by González Hernández, Manuel A., Verschuren, Lars, Caspers, Martien P.M., Morrison, Martine C., Venhorst, Jennifer, van den Berg, Jelle T., Coornaert, Beatrice, Hanemaaijer, Roeland, van Westen, Gerard J. P.

“…The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial…”
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Unraveling the Transcriptional Dynamics of NASH Pathogenesis Affecting Atherosclerosis by van den Hoek, Anita M, Özsezen, Serdar, Caspers, Martien P M, van Koppen, Arianne, Hanemaaijer, Roeland, Verschuren, Lars

“…The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in…”
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Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD by Verschuren, Lars, Mak, Anne Linde, van Koppen, Arianne, Özsezen, Serdar, Difrancesco, Sonia, Caspers, Martien P. M., Snabel, Jessica, van der Meer, David, van Dijk, Anne-Marieke, Rashu, Elias Badal, Nabilou, Puria, Werge, Mikkel Parsberg, van Son, Koen, Kleemann, Robert, Kiliaan, Amanda J., Hazebroek, Eric J., Boonstra, André, Brouwer, Willem P., Doukas, Michail, Gupta, Saurabh, Kluft, Cornelis, Nieuwdorp, Max, Verheij, Joanne, Gluud, Lise Lotte, Holleboom, Adriaan G., Tushuizen, Maarten E., Hanemaaijer, Roeland

“…Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study…”
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The composition of collagen in the aneurysm wall of men and women by Villard, Christina, MD, PhD, Eriksson, Per, PhD, Hanemaaijer, Roeland, PhD, Lindeman, Jan H., MD, PhD, Hultgren, Rebecka, MD, PhD

“…Background Loss of vessel wall integrity by degradation is essential for the development of abdominal aortic aneurysm (AAA) and ultimately its rupture. The…”
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Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases by Holmgren, Gustav, Ulfenborg, Benjamin, Asplund, Annika, Toet, Karin, Andersson, Christian X, Hammarstedt, Ann, Hanemaaijer, Roeland, Küppers-Munther, Barbara, Synnergren, Jane

“…There is a strong anticipated future for human induced pluripotent stem cell-derived hepatocytes (hiPS-HEP), but so far, their use has been limited due to…”
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Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis by Venhorst, Jennifer, Hanemaaijer, Roeland, Dulos, Remon, Caspers, Martien P M, Toet, Karin, Attema, Joline, de Ruiter, Christa, Kalkman, Gino, Rouhani Rankouhi, Tanja, de Jong, Jelle C B C, Verschuren, Lars

“…An target discovery pipeline was developed by including a directional and weighted molecular disease network for metabolic dysfunction-associated…”
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A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation by van der Meij, Evelien, Koning, Giel G, Vriens, Patrick W, Peeters, Marcel F, Meijer, C Arnoud, Kortekaas, Kim E, Dalman, Ronald L, van Bockel, J Hajo, Hanemaaijer, Roeland, Kooistra, Teake, Kleemann, Robert, Lindeman, Jan H N

“…Statins are thought to reduce vascular inflammation through lipid independent mechanisms. Evaluation of such an effect in atherosclerotic disease is…”
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Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content by Abdul-Hussien, Hazem, MD, Hanemaaijer, Roeland, PhD, Verheijen, Jan H., PhD, van Bockel, J. Hajo, MD, PhD, Geelkerken, Robert H., MD, PhD, Lindeman, Jan H.N., MD, PhD

“…Background Matrix metalloproteinase-9 (MMP-9) is thought to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline, a tetracycline…”
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Butyrate Protects against Diet-Induced NASH and Liver Fibrosis and Suppresses Specific Non-Canonical TGF-β Signaling Pathways in Human Hepatic Stellate Cells by Gart, Eveline, van Duyvenvoorde, Wim, Toet, Karin, Caspers, Martien P M, Verschuren, Lars, Nielsen, Mette Juul, Leeming, Diana Julie, Souto Lima, Everton, Menke, Aswin, Hanemaaijer, Roeland, Keijer, Jaap, Salic, Kanita, Kleemann, Robert, Morrison, Martine C

“…In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular damage and inflammation are key drivers of fibrosis, which is the main…”
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Key Inflammatory Processes in Human NASH Are Reflected in Ldlr -/- .Leiden Mice: A Translational Gene Profiling Study by Morrison, Martine C, Kleemann, Robert, van Koppen, Arianne, Hanemaaijer, Roeland, Verschuren, Lars

“…It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix…”
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Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice by Morrison, Martine C., Verschuren, Lars, Salic, Kanita, Verheij, Joanne, Menke, Aswin, Wielinga, Peter Y., Iruarrizaga‐Lejarreta, Marta, Gole, Laurent, Yu, Wei‐Miao, Turner, Scott, Caspers, Martien P.M., Martínez‐Arranz, Ibon, Pieterman, Elsbet, Stoop, Reinout, van Koppen, Arianne, van den Hoek, Anita M., Mato, José M., Hanemaaijer, Roeland, Alonso, Cristina, Kleemann, Robert

“…Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH)…”
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Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model by van Koppen, Arianne, Verschuren, Lars, van den Hoek, Anita M, Verheij, Joanne, Morrison, Martine C, Li, Kelvin, Nagabukuro, Hiroshi, Costessi, Adalberto, Caspers, Martien P.M, van den Broek, Tim J, Sagartz, John, Kluft, Cornelis, Beysen, Carine, Emson, Claire, van Gool, Alain J, Goldschmeding, Roel, Stoop, Reinout, Bobeldijk-Pastorova, Ivana, Turner, Scott M, Hanauer, Guido, Hanemaaijer, Roeland

“…Background & Aims The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events…”
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Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD by Vernooy, Juanita H J, Lindeman, Jan H N, Jacobs, Jan A, Hanemaaijer, Roeland, Wouters, Emiel F M

“…The increased expression of matrix metalloproteinases (MMPs) is considered to be a key factor in the development of COPD. Net MMP activity represents a tightly…”
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Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis by van der Slot, Annemarie J., Zuurmond, Anne-Marie, Bardoel, Alfons F.J., Wijmenga, Cisca, Pruijs, Hans E.H., Sillence, David O., Brinckmann, Jürgen, Abraham, David J., Black, Carol M., Verzijl, Nicole, DeGroot, Jeroen, Hanemaaijer, Roeland, TeKoppele, Johan M., Huizinga, Tom W.J., Bank, Ruud A.

“…The hallmark of fibrotic processes is an excessive accumulation of collagen. The deposited collagen shows an increase in pyridinoline cross-links, which are…”
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Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer by Kubben, Frank J.G.M, Sier, Cornelis F.M, Hawinkels, Lukas J.A.C, Tschesche, Harald, van Duijn, Wim, Zuidwijk, Kim, van der Reijden, Johan J, Hanemaaijer, Roeland, Griffioen, Gerrit, Lamers, Cornelis B.H.W, Verspaget, Hein W

“…Abstract Recently, complexes of matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) with lipocalin-2 (neutrophil gelatinase-associated lipocalin) were…”
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Pathogenic Sequence for Dissecting Aneurysm Formation in a Hypomorphic Polycystic Kidney Disease 1 Mouse Model by Hassane, Sabrine, Claij, Nanna, Lantinga-van Leeuwen, Irma S, Van Munsteren, J Conny, Van Lent, Natascha, Hanemaaijer, Roeland, Breuning, Martijn H, Peters, Dorien J.M, DeRuiter, Marco C

“…OBJECTIVE—Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a multi-system disorder characterized by progressive cyst formation in the kidneys. Serious…”
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Identification of free nitric oxide radicals in rat bone marrow: implications for progenitor cell mobilization in hypertension by Aleksinskaya, Marina A, van Faassen, Ernst E H, Nelissen, Jelly, Janssen, Ben J A, De Mey, Jo G R, Hanemaaijer, Roeland, Rabelink, Ton, van Zonneveld, Anton Jan

“…Nitric oxide (NO) has been implicated in matrix metallopeptidase 9 (MMP9)-dependent mobilization of hematopoietic stem and progenitor cells from bone marrow…”
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Cathepsin K Is the Principal Protease in Giant Cell Tumor of Bone by Lindeman, Jan H.N., Hanemaaijer, Roeland, Mulder, Adri, Dijkstra, P.D. Sander, Szuhai, Károly, Bromme, Dieter, Verheijen, Jan H., Hogendoorn, Pancras C.W.

“…Giant cell tumor (GCT) of bone is a neoplasm of bone characterized by a localized osteolytic lesion. The nature of GCT is an enigma and the cell type(s) and…”
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