Search Results - "HANEL, Art"

Discovery of a new class of glucosylceramide synthase inhibitors by Koltun, Elena, Richards, Steven, Chan, Vicky, Nachtigall, Jason, Du, Hongwang, Noson, Kevin, Galan, Adam, Aay, Naing, Hanel, Art, Harrison, Amanda, Zhang, Jeff, Won, Kwang-Ai, Tam, Danny, Qian, Fawn, Wang, Tao, Finn, Patricia, Ogilvie, Kathleen, Rosen, Jon, Mohan, Raju, Larson, Christopher, Lamb, Peter, Nuss, John, Kearney, Patrick

“…A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties…”
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Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1 by FOLKES, Adrian, BROWN, S. David, LEAHY, James W, MACH, Morrison, MATTHEWS, David, PRISBYLLA, Michael P, SANDERSON, Jason, SIMON, Reyna J, TESFAI, Zerom, VICKER, Nigel, WANG, Shouming, WEBB, Robert R, CANNE, Lynne E, CHARLTON, Peter, CHAN, Jocelyn, ENGELHARDT, Erin, EPSHTEYN, Sergey, FAINT, Richard, GOLEC, Julian, HANEL, Art, KEARNEY, Patrick

“…We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These…”
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Identification and Characterization of Small-Molecule Inhibitors of the R132H/R132H Mutant Isocitrate Dehydrogenase 1 Homodimer and R132H/Wild-Type Heterodimer by Brooks, Eric, Wu, Xiang, Hanel, Art, Nguyen, Shaun, Wang, Jing, Zhang, Jeffrey H, Harrison, Amanda, Zhang, Wentao

“…Recurrent genetic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) have been identified in multiple tumor types. The most frequent mutation, IDH1…”
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Discovery and Characterization of an Inhibitor of Glucosylceramide Synthase by Richards, Steven, Larson, Christopher J, Koltun, Elena S, Hanel, Art, Chan, Vicky, Nachtigall, Jason, Harrison, Amanda, Aay, Naing, Du, Hongwang, Arcalas, Arlyn, Galan, Adam, Zhang, Jeff, Zhang, Wentao, Won, Kwang-Ai, Tam, Danny, Qian, Fawn, Wang, Tao, Finn, Patricia, Ogilvie, Kathy, Rosen, Jon, Aoyama, Ron, Plonowski, Artur, Cancilla, Belinda, Bentzien, Frauke, Yakes, Michael, Mohan, Raju, Lamb, Peter, Nuss, John, Kearney, Patrick

“…Targeting glycosphingolipid synthesis has emerged as a novel approach for treating metabolic diseases. 32 (EXEL-0346) represents a new class of…”
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