Search Results - "HANDY, Diane E"

Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities by Lubos, Edith, Loscalzo, Joseph, Handy, Diane E

“…Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all cells by mitochondrial and enzymatic sources. Left unchecked, these…”
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Network-based approach to prediction and population-based validation of in silico drug repurposing by Cheng, Feixiong, Desai, Rishi J., Handy, Diane E., Wang, Ruisheng, Schneeweiss, Sebastian, Barabási, Albert-László, Loscalzo, Joseph

“…Here we identify hundreds of new drug-disease associations for over 900 FDA-approved drugs by quantifying the network proximity of disease genes and drug…”
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Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology by Handy, Diane E., Joseph, Jacob, Loscalzo, Joseph

“…Selenium (Se) is a trace nutrient that promotes human health through its incorporation into selenoproteins in the form of the redox-active amino acid…”
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A genome-wide positioning systems network algorithm for in silico drug repurposing by Cheng, Feixiong, Lu, Weiqiang, Liu, Chuang, Fang, Jiansong, Hou, Yuan, Handy, Diane E., Wang, Ruisheng, Zhao, Yuzheng, Yang, Yi, Huang, Jin, Hill, David E., Vidal, Marc, Eng, Charis, Loscalzo, Joseph

“…Recent advances in DNA/RNA sequencing have made it possible to identify new targets rapidly and to repurpose approved drugs for treating heterogeneous diseases…”
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Early pregnancy vitamin D status and risk of preeclampsia by Mirzakhani, Hooman, Litonjua, Augusto A, McElrath, Thomas F, O'Connor, George, Lee-Parritz, Aviva, Iverson, Ronald, Macones, George, Strunk, Robert C, Bacharier, Leonard B, Zeiger, Robert, Hollis, Bruce W, Handy, Diane E, Sharma, Amitabh, Laranjo, Nancy, Carey, Vincent, Qiu, Weilliang, Santolini, Marc, Liu, Shikang, Chhabra, Divya, Enquobahrie, Daniel A, Williams, Michelle A, Loscalzo, Joseph, Weiss, Scott T

“…Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia. We assessed the effect of vitamin D supplementation (4,400 vs. 400 IU/day),…”
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Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension by MARON, Bradley A, ZHANG, Ying-Yi, WHITE, Kevin, CHAN, Stephen Y, HANDY, Diane E, MAHONEY, Christopher E, LOSCALZO, Joseph, LEOPOLD, Jane A

“…Pulmonary arterial hypertension (PAH) is characterized, in part, by decreased endothelial nitric oxide (NO(·)) production and elevated levels of endothelin-1…”
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High glucose–induced ubiquitination of G6PD leads to the injury of podocytes by Wang, Meng, Hu, Ji, Yan, Linling, Yang, Yeping, He, Min, Wu, Meng, Li, Qin, Gong, Wei, Yang, Yang, Wang, Yi, Handy, Diane E., Lu, Bin, Hao, Chuanming, Wang, Qinghua, Li, Yiming, Hu, Ronggui, Stanton, Robert C., Zhang, Zhaoyun

“…ABSTRACTOxidative stress contributes substantially to podocyte injury, which plays an important role in the development of diabetic kidney disease. The…”
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Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice by Labunskyy, Vyacheslav M, Lee, Byung Cheon, Handy, Diane E, Loscalzo, Joseph, Hatfield, Dolph L, Gladyshev, Vadim N

“…Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins. Whereas optimal levels of Se in the…”
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Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification by Liberman, Marcel, Johnson, Rebecca C., Handy, Diane E., Loscalzo, Joseph, Leopold, Jane A.

“…► BMP-2 increases NADPH oxidase activity in human coronary smooth muscle cells. ► NADPH oxidase activity is increased via BMPR2 and Smad 1. ► Increased NADPH…”
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The role of glutathione peroxidase-1 in health and disease by Handy, Diane E., Loscalzo, Joseph

“…Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of mammalian cells. Like most…”
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Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo by JIN, Richard C, MAHONEY, Christopher E, ANDERSON, Laura, OTTAVIANO, Filomena, CROCE, Kevin, LEOPOLD, Jane A, ZHANG, Ying-Yi, TANG, Shiow-Shih, HANDY, Diane E, LOSCALZO, Joseph

“…Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A…”
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Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses by Handy, Diane E., Lubos, Edith, Yang, Yi, Galbraith, John D., Kelly, Neil, Zhang, Ying-Yi, Leopold, Jane A., Loscalzo, Joseph

“…Glutathione peroxidase-1 (GPx-1) is a selenocysteine-containing enzyme that plays a major role in the reductive detoxification of peroxides in cells. In…”
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Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case by Garmaroudi, Farshid S, Handy, Diane E, Liu, Yang-Yu, Loscalzo, Joseph

“…Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure…”
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NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism by Xiao, Wusheng, Wang, Rui-Sheng, Handy, Diane E, Loscalzo, Joseph

“…The nicotinamide adenine dinucleotide (NAD )/reduced NAD (NADH) and NADP /reduced NADP (NADPH) redox couples are essential for maintaining cellular redox…”
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Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease by HANDY, Diane E, CASTRO, Rita, LOSCALZO, Joseph

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Redox regulation of mitochondrial function by Handy, Diane E, Loscalzo, Joseph

“…Redox-dependent processes influence most cellular functions, such as differentiation, proliferation, and apoptosis. Mitochondria are at the center of these…”
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Redox Regulation in the Extracellular Environment by Ottaviano, Filomena G., Handy, Diane E., Loscalzo, Joseph

“…The oxidizing nature of the extracellular environment is vastly different from the highly reducing nature of the intracellular compartment. The redox potential…”
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Responses to reductive stress in the cardiovascular system by Handy, Diane E., Loscalzo, Joseph

“…There is a growing appreciation that reductive stress represents a disturbance in the redox state that is harmful to biological systems. On a cellular level,…”
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Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression by Barroso, Madalena, Florindo, Cristina, Kalwa, Hermann, Silva, Zélia, Turanov, Anton A., Carlson, Bradley A., de Almeida, Isabel Tavares, Blom, Henk J., Gladyshev, Vadim N., Hatfield, Dolph L., Michel, Thomas, Castro, Rita, Loscalzo, Joseph, Handy, Diane E.

“…S-Adenosylhomocysteine (SAH) is a negative regulator of most methyltransferases and the precursor for the cardiovascular risk factor homocysteine. We have…”
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Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation by Lubos, Edith, Kelly, Neil J., Oldebeken, Scott R., Leopold, Jane A., Zhang, Ying-Yi, Loscalzo, Joseph, Handy, Diane E.

“…Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant enzyme, the deficiency of which promotes atherogenesis. Accordingly, we examined the mechanisms by…”
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