Search Results - "HANCOX, J. C"

Pharmacology of the short QT syndrome N588K‐hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs by McPate, M J, Duncan, R S, Hancox, J C, Witchel, H J

“…Background and purpose: The short QT syndrome (SQTS) is associated with cardiac arrhythmias and sudden death. The SQT1 form of SQTS results from an…”
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One-Dimensional Mathematical Model of the Atrioventricular Node Including Atrio-Nodal, Nodal, and Nodal-His Cells by Inada, S., Hancox, J.C., Zhang, H., Boyett, M.R.

“…Mathematical models are a repository of knowledge as well as research and teaching tools. Although action potential models have been developed for most regions…”
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Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone by Hancox, JC

“…The hypoglycaemic thiazolidinedione rosiglitazone is used clinically in the treatment of type 2 diabetes. However, in 2010, information relating to…”
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VEGF Activates Receptor-Operated Cation Channels in Human Microvascular Endothelial Cells by Cheng, H -W, James, A F, Foster, R R, Hancox, J C, Bates, D O

“…OBJECTIVE—Vascular endothelial growth factor (VEGF) exerts many of its effects by stimulating endothelial calcium influx, but little is known about channels…”
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Polyaromatic hydrocarbons in pollution: a heart‐breaking matter by Marris, C. R., Kompella, S. N., Miller, M. R., Incardona, J. P., Brette, F., Hancox, J. C., Sørhus, E., Shiels, H. A.

“…Air pollution is associated with detrimental effects on human health, including decreased cardiovascular function. However, the causative mechanisms behind…”
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Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin by Duncan, R.S., McPate, M.J., Ridley, J.M., Gao, Z., James, A.F., Leishman, D.J., Leaney, J.L., Witchel, H.J., Hancox, J.C.

“…HERG (human ether-à-go-go-related gene) encodes channels responsible for the cardiac rapid delayed rectifier potassium current, IKr. This study investigated…”
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Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome by Hancox, J C, Du, C Y, Butler, A, Zhang, Y, Dempsey, C E, Harmer, S C, Zhang, H

“…The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated rate-corrected QT (QTc) intervals on the electrocardiogram and by…”
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The key characteristics of cardiotoxicity for the pervasive pollutant phenanthrene by England, E., Morris, J.W., Bussy, C., Hancox, J.C., Shiels, H.A.

“…The key characteristic (KCs) framework has been used previously to assess the carcinogenicity and cardiotoxicity of various chemical and pharmacological…”
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Cultured adult cardiac myocytes : Future applications, culture methods, morphological and electrophysiological properties by MITCHESON, J. S, HANCOX, J. C, LEVI, A. J

“…Isolated adult cardiac myocytes maintained in primary culture have been used as a model of the adult myocardium for 20 years. With the recent advances and…”
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Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine by Ridley, J. M., Milnes, J. T., Zhang, Y. H., Witchel, H. J., Hancox, J. C.

“…4-Aminopyridine (4-AP) has been used extensively to study transient outward K + current ( I TO,1 ) in cardiac cells and tissues. We report here inhibition by…”
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Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential by Hancox, J C, Levi, A J, Witchel, H J

“…It is widely believed that HERG (human ether-a-go-go-related gene) encodes the major subunit of the cardiac "rapid" delayed rectifier K channel. The aims of…”
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Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline by Teschemacher, Anja G, Seward, Elizabeth P, Hancox, Jules C, Witchel, Harry J

“…Tricyclic antidepressants (TCAs) are associated with cardiovascular side effects including prolongation of the QT interval of the ECG. In this report we…”
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Paradoxical effects of insulin on cardiac L-type calcium current and on contraction at physiological temperature by PABBATHI, V. K, SULEIMAN, M. S, HANCOX, J. C

“…L-type calcium current (I(Ca,L)) is a major determinant of mammalian cardiac contraction, and data from studies performed at room temperature suggest that this…”
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ORM‐10103: a significant advance in sodium‐calcium exchanger pharmacology? by Terracciano, C M, Hancox, J C

“…The sodium‐calcium exchanger (NCX) is an electrogenic transporter that is widely expressed in different tissues. In the heart, the NCX plays important roles in…”
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Effects of BDF 9198 on action potentials and ionic currents from guinea‐pig isolated ventricular myocytes by Yuill, K H, Convery, M K, Dooley, P C, Doggrell, S A, Hancox, J C

“…BDF 9198 (a congener of DPI 201–106 and BDF 9148) was found to be a positive inotrope on guinea‐pig isolated ventricular muscle strips. The effects of BDF 9198…”
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Antiarrhythmics—from cell to clinic: past, present, and future by Hancox, J C, Patel, K C R, Jones, J V

“…[...]we may be on the verge of an era where arrhythmia management will no longer be dominated by trial and error based observational treatment. [...]we shall…”
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A method for isolating rabbit atrioventricular node myocytes which retain normal morphology and function by Hancox, J C, Levi, A J, Lee, C O, Heap, P

“…This report describes a method for isolating single rabbit atrioventricular (AV) node myocytes which retain their normal morphology when exposed to millimolar…”
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An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes by Mitcheson, J S, Hancox, J C

“…The aim of this study was to measure and compare the profile of rapid delayed rectifier potassium current (IKr) elicited by action potential (AP) waveforms…”
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Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis by DU, C.Y., EL HARCHI, A., ZHANG, Y.H., ORCHARD, C.H., HANCOX, J.C.

“…Acidosis and hERG K+ Channel Pharmacology.  Introduction: Human Ether‐à‐go‐go related gene (hERG) is responsible for channels that mediate the rapid delayed…”
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Application of Micro-Computed Tomography With Iodine Staining to Cardiac Imaging, Segmentation, and Computational Model Development by Aslanidi, O. V., Nikolaidou, T., Jichao Zhao, Smaill, B. H., Gilbert, S. H., Holden, A. V., Lowe, T., Withers, P. J., Stephenson, R. S., Jarvis, J. C., Hancox, J. C., Boyett, M. R., Henggui Zhang

“…Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for…”
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