Search Results - "HAMMOND, Christopher J"

Predictors of Discordance between Symptoms and Signs in Dry Eye Disease by Vehof, Jelle, MD, PhD, Sillevis Smitt-Kamminga, Nicole, MD, Nibourg, Simone A., BSc, Hammond, Christopher J., MD, FRCOphth

“…Purpose To investigate predictors of discordance between symptoms and signs in dry eye disease (DED). Design Cross-sectional association study. Participants A…”
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Prevalence and risk factors of dry eye disease in a British female cohort by Vehof, Jelle, Kozareva, Diana, Hysi, Pirro G, Hammond, Christopher J

“…To estimate the prevalence and risk factors of dry eye disease (DED) in a female cohort in the UK. Population-based cross-sectional association study of 3824…”
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The UK Adult Twin Registry (TwinsUK Resource) by Moayyeri, Alireza, Hammond, Christopher J., Hart, Deborah J., Spector, Timothy D.

“…TwinsUK is a nation-wide registry of volunteer twins in the United Kingdom, with about 12,000 registered twins (83% female, equal number of monozygotic and…”
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Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia by Hysi, Pirro G., Choquet, Hélène, Khawaja, Anthony P., Wojciechowski, Robert, Tedja, Milly S., Yin, Jie, Simcoe, Mark J., Patasova, Karina, Mahroo, Omar A., Thai, Khanh K., Cumberland, Phillippa M., Melles, Ronald B., Verhoeven, Virginie J. M., Vitart, Veronique, Segre, Ayellet, Stone, Richard A., Wareham, Nick, Hewitt, Alex W., Mackey, David A., Klaver, Caroline C. W., MacGregor, Stuart, Khaw, Peng T., Foster, Paul J., Guggenheim, Jeremy A., Rahi, Jugnoo S., Jorgenson, Eric, Hammond, Christopher J.

“…Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the…”
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Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression by Craig, Jamie E., Han, Xikun, Qassim, Ayub, Hassall, Mark, Cooke Bailey, Jessica N., Kinzy, Tyler G., Khawaja, Anthony P., An, Jiyuan, Marshall, Henry, Gharahkhani, Puya, Igo, Robert P., Graham, Stuart L., Healey, Paul R., Ong, Jue-Sheng, Zhou, Tiger, Siggs, Owen, Law, Matthew H., Souzeau, Emmanuelle, Ridge, Bronwyn, Hysi, Pirro G., Burdon, Kathryn P., Mills, Richard A., Landers, John, Ruddle, Jonathan B., Agar, Ashish, Galanopoulos, Anna, White, Andrew J. R., Willoughby, Colin E., Andrew, Nicholas H., Best, Stephen, Vincent, Andrea L., Goldberg, Ivan, Radford-Smith, Graham, Martin, Nicholas G., Montgomery, Grant W., Vitart, Veronique, Hoehn, Rene, Wojciechowski, Robert, Jonas, Jost B., Aung, Tin, Pasquale, Louis R., Cree, Angela Jane, Sivaprasad, Sobha, Vallabh, Neeru A., Viswanathan, Ananth C., Pasutto, Francesca, Haines, Jonathan L., Klaver, Caroline C. W., van Duijn, Cornelia M., Casson, Robert J., Foster, Paul J., Khaw, Peng Tee, Hammond, Christopher J., Mackey, David A., Mitchell, Paul, Lotery, Andrew J., Wiggs, Janey L., Hewitt, Alex W., MacGregor, Stuart

“…Glaucoma, a disease characterized by progressive optic nerve degeneration, can be prevented through timely diagnosis and treatment. We characterize optic nerve…”
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Human metabolic individuality in biomedical and pharmaceutical research by Suhre, Karsten, Shin, So-Youn, Petersen, Ann-Kristin, Mohney, Robert P., Meredith, David, Wägele, Brigitte, Altmaier, Elisabeth, Deloukas, Panos, Erdmann, Jeanette, Grundberg, Elin, Hammond, Christopher J., de Angelis, Martin Hrabé, Kastenmüller, Gabi, Köttgen, Anna, Kronenberg, Florian, Mangino, Massimo, Meisinger, Christa, Meitinger, Thomas, Mewes, Hans-Werner, Milburn, Michael V., Prehn, Cornelia, Raffler, Johannes, Ried, Janina S., Römisch-Margl, Werner, Samani, Nilesh J., Small, Kerrin S., -Erich Wichmann, H., Zhai, Guangju, Illig, Thomas, Spector, Tim D., Adamski, Jerzy, Soranzo, Nicole, Gieger, Christian

“…Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the…”
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Increasing Prevalence of Myopia in Europe and the Impact of Education by Williams, Katie M., MPhil, FRCOphth, Bertelsen, Geir, MD, PhD, Cumberland, Phillippa, MSc, BA, Wolfram, Christian, MD, Verhoeven, Virginie J.M., MD, MSc, Anastasopoulos, Eleftherios, MD, Buitendijk, Gabriëlle H.S., MD, MSc, Cougnard-Grégoire, Audrey, PhD, Creuzot-Garcher, Catherine, MD, PhD, Erke, Maja Gran, MD, PhD, Hogg, Ruth, PhD, Höhn, René, MD, Hysi, Pirro, MD, PhD, Khawaja, Anthony P., MPhil, FRCOphth, Korobelnik, Jean-François, MD, Ried, Janina, PhD, Vingerling, Johannes R., MD, PhD, Bron, Alain, MD, Dartigues, Jean-François, MD, PhD, Fletcher, Astrid, PhD, Hofman, Albert, MD, PhD, Kuijpers, Robert W.A.M., MD, PhD, Luben, Robert N., MSc, Oxele, Konrad, MD, Topouzis, Fotis, MD, PhD, von Hanno, Therese, MD, PhD, Mirshahi, Alireza, MD, Foster, Paul J., PhD, FRCOphth, van Duijn, Cornelia M., PhD, Pfeiffer, Norbert, MD, Delcourt, Cécile, PhD, Klaver, Caroline C.W., MD, PhD, Rahi, Jugnoo, PhD, FRCOphth, Hammond, Christopher J., MD, FRCOphth

“…Purpose To investigate whether myopia is becoming more common across Europe and explore whether increasing education levels, an important environmental risk…”
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A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers by Vehof, Jelle, MD, PhD, Hysi, Pirro G., MD, PhD, Hammond, Christopher J., MD, FRCOphth

“…Purpose To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. Design Cross-sectional…”
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The relationship between dry eye and sleep quality by Magno, Morten Schjerven, Utheim, Tor Paaske, Snieder, Harold, Hammond, Christopher J., Vehof, Jelle

“…Sleep is an important determinant of health and quality of life. This study aimed to clarify the association between dry eye and sleep quality using a large…”
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Prevalence of refractive error in Europe: the European Eye Epidemiology (E³) Consortium by Williams, Katie M., Verhoeven, Virginie J. M., Cumberland, Phillippa, Bertelsen, Geir, Wolfram, Christian, Buitendijk, Gabriëlle H. S., Hofman, Albert, van Duijn, Cornelia M., Vingerling, Johannes R., Kuijpers, Robert W. A. M., Höhn, René, Mirshahi, Alireza, Khawaja, Anthony P., Luben, Robert N., Erke, Maja Gran, von Hanno, Therese, Mahroo, Omar, Hogg, Ruth, Gieger, Christian, Cougnard-Grégoire, Audrey, Anastasopoulos, Eleftherios, Bron, Alain, Dartigues, Jean-François, Korobelnik, Jean-François, Creuzot-Garcher, Catherine, Topouzis, Fotis, Delcourt, Cécile, Rahi, Jugnoo, Meitinger, Thomas, Fletcher, Astrid, Foster, Paul J., Pfeiffer, Norbert, Klaver, Caroline C. W., Hammond, Christopher J.

“…To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from…”
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Shared genetic factors underlie chronic pain syndromes by Vehof, Jelle, Zavos, Helena M.S., Lachance, Genevieve, Hammond, Christopher J., Williams, Frances M.K.

“…Using a large population-representative sample and multivariate twin modeling, the presence of shared genetic factors underlying chronic pain syndromes was…”
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The Role of Pharmacotherapy in the Treatment of Adolescent Substance Use Disorders by Hammond, Christopher J., MD

“…Adolescent substance use disorders (SUDs) are a significant public health issue due to the associated morbidity, mortality, and societal cost. While effective…”
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Temporal trends in frequency, type and severity of myopia and associations with key environmental risk factors in the UK: Findings from the UK Biobank Study by Cumberland, Phillippa M, Bountziouka, Vasiliki, Hammond, Christopher J, Hysi, Pirro G, Rahi, Jugnoo S

“…This study investigated temporal trends in the epidemiology of primary myopia and associations with key environmental risk factors in a UK population. Data…”
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The architecture of gene regulatory variation across multiple human tissues: the MuTHER study by Nica, Alexandra C, Parts, Leopold, Glass, Daniel, Nisbet, James, Barrett, Amy, Sekowska, Magdalena, Travers, Mary, Potter, Simon, Grundberg, Elin, Small, Kerrin, Hedman, Asa K, Bataille, Veronique, Tzenova Bell, Jordana, Surdulescu, Gabriela, Dimas, Antigone S, Ingle, Catherine, Nestle, Frank O, di Meglio, Paola, Min, Josine L, Wilk, Alicja, Hammond, Christopher J, Hassanali, Neelam, Yang, Tsun-Po, Montgomery, Stephen B, O'Rahilly, Steve, Lindgren, Cecilia M, Zondervan, Krina T, Soranzo, Nicole, Barroso, Inês, Durbin, Richard, Ahmadi, Kourosh, Deloukas, Panos, McCarthy, Mark I, Dermitzakis, Emmanouil T, Spector, Timothy D

“…While there have been studies exploring regulatory variation in one or more tissues, the complexity of tissue-specificity in multiple primary tissues is not…”
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Time spent outdoors in childhood is associated with reduced risk of myopia as an adult by Lingham, Gareth, Yazar, Seyhan, Lucas, Robyn M., Milne, Elizabeth, Hewitt, Alex W., Hammond, Christopher J., MacGregor, Stuart, Rose, Kathryn A., Chen, Fred K., He, Mingguang, Guggenheim, Jeremy A., Clarke, Michael W., Saw, Seang-Mei, Williams, Cathy, Coroneo, Minas T., Straker, Leon, Mackey, David A.

“…Myopia (near-sightedness) is an important public health issue. Spending more time outdoors can prevent myopia but the long-term association between this…”
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Frequency and Distribution of Refractive Error in Adult Life: Methodology and Findings of the UK Biobank Study by Cumberland, Phillippa M, Bao, Yanchun, Hysi, Pirro G, Foster, Paul J, Hammond, Christopher J, Rahi, Jugnoo S

“…To report the methodology and findings of a large scale investigation of burden and distribution of refractive error, from a contemporary and ethnically…”
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Association Between Myopia, Ultraviolet B Radiation Exposure, Serum Vitamin D Concentrations, and Genetic Polymorphisms in Vitamin D Metabolic Pathways in a Multicountry European Study by Williams, Katie M, Bentham, Graham C G, Young, Ian S, McGinty, Ann, McKay, Gareth J, Hogg, Ruth, Hammond, Christopher J, Chakravarthy, Usha, Rahu, Mati, Seland, Johan, Soubrane, Gisele, Tomazzoli, Laura, Topouzis, Fotis, Fletcher, Astrid E

“…Myopia is becoming increasingly common globally and is associated with potentially sight-threatening complications. Spending time outdoors is protective, but…”
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Digital quantification of human eye color highlights genetic association of three new loci by Liu, Fan, Wollstein, Andreas, Hysi, Pirro G, Ankra-Badu, Georgina A, Spector, Timothy D, Park, Daniel, Zhu, Gu, Larsson, Mats, Duffy, David L, Montgomery, Grant W, Mackey, David A, Walsh, Susan, Lao, Oscar, Hofman, Albert, Rivadeneira, Fernando, Vingerling, Johannes R, Uitterlinden, André G, Martin, Nicholas G, Hammond, Christopher J, Kayser, Manfred

“…Previous studies have successfully identified genetic variants in several genes associated with human iris (eye) color; however, they all used simplified…”
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Early Childhood Traumatic Events and Adolescent-Onset Illicit Drug Use: Implications for Prevention and Treatment by Hammond, Christopher J., MD

“…The link among childhood adversity (CA), trauma, and addiction is well known. Four decades of research have shown that exposure during childhood to a multitude…”
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Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands by Wolpert, Laura E., Snieder, Harold, Jansonius, Nomdo M., Utheim, Tor P., Hammond, Christopher J., Vehof, Jelle

“…To date, population-based studies reporting associations between dry eye disease and medications were hypothesis-driven, did not take into account underlying…”
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