Search Results - "HAMMOCK, BRUCE D"

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health by MORISSEAU, Christophe, HAMMOCK, Bruce D

“…The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years…”
Get full text

Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies by Hildreth, Kelsey, Kodani, Sean D., Hammock, Bruce D., Zhao, Ling

“…Linoleic acid (LA) is the most abundant polyunsaturated fatty acid found in the Western diet. Cytochrome P450-derived LA metabolites 9,10-epoxyoctadecenoic…”
Get full text

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases by Wagner, Karen M, McReynolds, Cindy B, Schmidt, William K, Hammock, Bruce D

“…Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated fatty acids. Many of the actions of eicosanoid metabolites formed by…”
Get full text

Rapid Measurement of Residual Kanamycin Using Highly Specific Biomimetic Recognition Paper-Based Chip by Song, Jian, He, Kaiyu, Xing, Bingcong, Pei, Yong, Wang, Dingnan, Wang, Yang, Li, Shiyan, Li, Jie, Huan, Weiwei, Zhang, Yiming, Hammock, Bruce. D.

“…The development of highly specific biomimetic recognition material is a challenge for rapid detection of harmful residues in foodstuff. In this study, a…”
Get full text

Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative by Hammock, Bruce D, McReynolds, Cindy B, Wagner, Karen, Buckpitt, Alan, Cortes-Puch, Irene, Croston, Glenn, Lee, Kin Sing Stephen, Yang, Jun, Schmidt, William K, Hwang, Sung Hee

“…This report describes the development of an orally active analgesic that resolves inflammation and neuropathic pain without the addictive potential of opioids…”
Get full text

Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain–gut–microbiota axis via the subdiaphragmatic vagus nerve by Wang, Siming, Ishima, Tamaki, Qu, Youge, Shan, Jiajing, Chang, Lijia, Wei, Yan, Zhang, Jiancheng, Pu, Yaoyu, Fujita, Yuko, Tan, Yunfei, Wang, Xingming, Ma, Li, Wan, Xiayun, Hammock, Bruce D., Hashimoto, Kenji

“…•Ephx2 KO mice do not show depression-like phenotypes after chronic social defeat stress (CSDS).•Fecal microbiota transplantation (FMT) from CSDS-susceptible…”
Get full text

Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase by Pu, Yaoyu, Yang, Jun, Chang, Lijia, Qu, Youge, Wang, Siming, Zhang, Kai, Xiong, Zhongwei, Zhang, Jiancheng, Tan, Yunfei, Wang, Xingming, Fujita, Yuko, Ishima, Tamaki, Wang, Debin, Hwang, Sung Hee, Hammock, Bruce D., Hashimoto, Kenji

“…Epidemiological studies suggest that exposure to herbicides during pregnancy might increase risk for autism spectrum disorder (ASD) in offspring. However, the…”
Get full text

Mass spectrometry-based metabolomics by Dettmer, Katja, Aronov, Pavel A., Hammock, Bruce D.

“…This review presents an overview of the dynamically developing field of mass spectrometry‐based metabolomics. Metabolomics aims at the comprehensive and…”
Get full text

An Innovative Nanobody-Based Electrochemical Immunosensor Using Decorated Nylon Nanofibers for Point-of-Care Monitoring of Human Exposure to Pyrethroid Insecticides by El-Moghazy, Ahmed Y, Huo, Jingqian, Amaly, Noha, Vasylieva, Natalia, Hammock, Bruce D, Sun, Gang

“…A novel ultrasensitive nanobody-based electrochemical immunoassay was prepared for assessing human exposure to pyrethroid insecticides. 3-Phenoxybenzoic acid…”
Get full text

Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry by Yang, Jun, Schmelzer, Kara, Georgi, Katrin, Hammock, Bruce D.

“…Cyclooxygenase, lipoxygenase, and epoxygenase derived oxylipins, especially eicosanoids, play important roles in many physiological processes. Assessment of…”
Get full text

A label-free optical whole-cell Escherichia coli biosensor for the detection of pyrethroid insecticide exposure by Riangrungroj, Pinpunya, Bever, Candace Spier, Hammock, Bruce D., Polizzi, Karen M.

“…There is a growing need for low-cost, portable technologies for the detection of threats to the environment and human health. Here we propose a label-free,…”
Get full text

commonly used antimicrobial additive triclosan is a liver tumor promoter by Yueh, Mei-Fei, Taniguchi, Koji, Chen, Shujuan, Evans, Ronald M., Hammock, Bruce D., Karin, Michael, Tukey, Robert H.

“…Significance Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a broad-spectrum antimicrobial agent that has become one of the most common additives…”
Get full text

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease by Ren, Qian, Ma, Min, Yang, Jun, Nonaka, Risa, Yamaguchi, Akihiro, Ishikawa, Kei-ichi, Kobayashi, Kenta, Murayama, Shigeo, Hwang, Sung Hee, Saiki, Shinji, Akamatsu, Wado, Hattori, Nobutaka, Hammock, Bruce D., Hashimoto, Kenji

“…Parkinson’s disease (PD) is characterized as a chronic and progressive neurodegenerative disorder, and the deposition of specific protein aggregates of…”
Get full text

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor by Gartung, Allison, Yang, Jun, Sukhatme, Vikas P., Bielenberg, Diane R., Fernandes, Djanira, Chang, Jaimie, Schmidt, Birgitta A., Hwang, Sung Hee, Zurakowski, David, Huang, Sui, Kieran, Mark W., Hammock, Bruce D., Panigrahy, Dipak

“…Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic microenvironment by triggering the release of proinflammatory…”
Get full text

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain by Inceoglu, Bora, Ahmed Bettaieb, Carlos A. Trindade da Silva, Kin Sing Stephen Lee, Fawaz G. Haj, Bruce D. Hammock

“…Despite intensive effort and resulting gains in understanding the mechanisms underlying neuropathic pain, limited success in therapeutic approaches have been…”
Get full text

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress by Ren, Qian, Ma, Min, Ishima, Tamaki, Morisseau, Christophe, Yang, Jun, Wagner, Karen M., Zhang, Ji-chun, Yang, Chun, Yao, Wei, Dong, Chao, Han, Mei, Hammock, Bruce D., Hashimoto, Kenji

“…Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the…”
Get full text

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides by López-Vicario, Cristina, Alcaraz-Quiles, José, García-Alonso, Verónica, Rius, Bibiana, Hwang, Sung H., Titos, Esther, Lopategi, Aritz, Hammock, Bruce D., Arroyo, Vicente, Clària, Joan

“…Significance Our study demonstrates that stabilization of cytochrome P-450 epoxides derived from omega-3 polyunsaturated fatty acids through inhibition of the…”
Get full text

Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor by Minaz, Nathani, Razdan, Rema, Hammock, Bruce D., Mujwar, Somdutt, Goswami, Sumanta Kumar

“…[Display omitted] •Administration of streptozotocin induces sexual dysfunction with a parallel decrease in the level of testosterone in rats.•Treatment with…”
Get full text

Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice by Liu, Yan, Dang, Huaixin, Li, Dan, Pang, Wei, Hammock, Bruce D, Zhu, Yi

“…Non-alcoholic fatty liver disease is associated with obesity and considered an inflammatory disease. Soluble epoxide hydrolase (sEH) is a major enzyme…”
Get full text

Development of a Highly Sensitive Direct Competitive Fluorescence Enzyme Immunoassay Based on a Nanobody–Alkaline Phosphatase Fusion Protein for Detection of 3‑Phenoxybenzoic Acid in Urine by Huo, Jingqian, Li, Zhenfeng, Wan, Debin, Li, Dongyang, Qi, Meng, Barnych, Bogdan, Vasylieva, Natalia, Zhang, Jinlin, Hammock, Bruce D

“…3-Phenoxybenzoic acid (3-PBA) is a human urinary metabolite of many pyrethroid insecticides and can be used as a biomarker to monitor human exposure to these…”
Get full text