Search Results - "HAMM, H. E"

Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa by Lokits, A D, Indrischek, H, Meiler, J, Hamm, H E, Stadler, P F

“…Heterotrimeric G proteins are fundamental signaling proteins composed of three subunits, Gα and a Gβγ dimer. The role of Gα as a molecular switch is critical…”
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How Activated Receptors Couple to G Proteins by Hamm, Heidi E.

“…G protein-coupled receptors (GPCRs) are involved in the control of every aspect of our behavior and physiology. This is the largest class of receptors, with…”
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Structural determinants for activation of the α-subunit of a heterotrimeric G protein by Lambright, David G, Noel, Joseph P, Hamm, Heidi E, Sigler, Paul B

“…The 1.8 A crystal structure of transducin alpha.GDP, when compared to that of the activated complex with GTP-gamma S, reveals the nature of the conformational…”
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Mathematical Model of the Spatio-Temporal Dynamics of Second Messengers in Visual Transduction by Andreucci, D., Bisegna, P., Caruso, G., Hamm, H.E., DiBenedetto, E.

“…A model describing the role of transversal and longitudinal diffusion of cGMP and Ca2+ in signaling in the rod outer segment of vertebrates is developed…”
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The Many Faces of G Protein Signaling by Hamm, Heidi E.

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A blue-light-activated GTP-binding protein in the plasma membranes of etiolated peas by Warpeha, K.M.F. (University of Illinois at Chicago, Chicago, IL), Hamm, H.E, Rasenick, M.M, Kaufman, L.S

“…Heterotrimeric GTP-binding regulatory proteins (G proteins) have been identified as part of signal transduction systems in a wide variety of organisms. In this…”
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Arrestin-rhodopsin interaction. Multi-site binding delineated by peptide inhibition by KRUPNICK, J. G, GUREVICH, V. V, SCHEPERS, T, HAMM, H. E, BENOVIC, J. L

“…Visual arrestin modulates the intracellular response of retinal rod cells to light by specifically binding to the phosphorylated light-activated form of the…”
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Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase by ARTEMYEV, N. O, HAMM, H. E

“…Light-activated cyclic GMP-phosphodiesterase (PDE) is the key effector enzyme of vertebrate photoreceptor cells which regulates the level of the internal…”
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The 2.0 Å crystal structure of a heterotrimeric G protein by Lambright, David G, Sondek, John, Bohm, Andrew, Skiba, Nikolai P, Hamm, Heidi E, Sigler, Paul B

“…The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates…”
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Regulation of transducin GTPase activity in bovine rod outer segments by ARSHAVSKY, V. Y, DUMKE, C. L, YUN ZHU, ARTEMYEV, N. O, SKIBA, N. P, HAMM, H. E, BOWNDS, M. D

“…The photoreceptor G-protein, transducin, belongs to the class of heterotrimeric GTP-binding proteins that transfer information from activated seven-span…”
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NMR structure of a receptor-bound G-protein peptide by Dratz, Edward A, Furstenau, Julie E, Lambert, Christophe G, Thireault, Dennis L, Rarick, Helen, Schepers, Theresa, Pakhlevaniants, Sergei, Hamm, Heidi E

“…Heterotrimeric GTP-binding proteins (G proteins) regulate cellular activity by coupling to hormone or sensory receptors. Stimulated receptors catalyse the…”
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The 2.2 Å crystal structure of transducin-α complexed with GTP γ S by Noel, Joseph P, Hamm, Heidi E, Sigler, Paul B

“…The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain…”
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Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism by ARTEMYEV, N. O, RARICK, H. M, MILLS, J. S, SKIBA, N. P, HAMM, H. E

“…In photoreceptor cells of vertebrates light activates a series of protein-protein interactions resulting in activation of a cGMP-phosphodiesterase (PDE)…”
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Mechanism of Photoreceptor cGMP Phosphodiesterase Inhibition by its γ -Subunits by Artemyev, Nikolai O., Natochin, Michael, Busman, Mark, Schey, Kevin L., Hamm, Heidi E.

“…cGMP phosphodiesterase (PDE) is the key effector enzyme of vertebrate photoreceptor cells that regulates the level of the second messenger, cGMP. PDE consists…”
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Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway by Minshall, R D, Tiruppathi, C, Vogel, S M, Niles, W D, Gilchrist, A, Hamm, H E, Malik, A B

“…We tested the hypothesis that the albumin-docking protein gp60, which is localized in caveolae, couples to the heterotrimeric GTP binding protein G(i), and…”
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Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin by Deretic, D, Hamm, H E

“…Antigenic sites for six monoclonal antibodies that bind to the alpha subunit (G alpha) of the photoreceptor guanyl nucleotide-binding protein (G-protein or…”
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Retinal rhythms in chicks: circadian variation in melantonin and serotonin N-acetyltransferase activity by Hamm, H E, Menaker, M

“…There is a large-amplitude circadian rhythm of indoleamine metabolism in the retina-pigment epithelium of the chicken. N-Acetyltransferase activity (arylamine…”
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A Site on Rod G Protein α Subunit That Mediates Effector Activation by Rarick, Helen M., Artemyev, Nikolai O., Hamm, Heidi E.

“…The heterotrimeric guanine nucleotide binding proteins (G proteins) are activated by sensory or hormone receptors. In turn, the G proteins activate effector…”
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A site on transducin alpha-subunit of interaction with the polycationic region of cGMP phosphodiesterase inhibitory subunit by ARTEMYEV, N. O, MILLS, J. S, THORNBURG, K. R, KNAPP, D. R, SCHEY, K. L, HAMM, H. E

“…Activation of cGMP phosphodiesterase (PDE) by the rod G-protein transducin is a key event in visual signal transduction in vertebrate photoreceptor cells…”
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Dynamics of mouse rod phototransduction and its sensitivity to variation of key parameters by Shen, L, Caruso, G, Bisegna, P, Andreucci, D, Gurevich, V V, Hamm, H E, DiBenedetto, E

“…The deep understanding of the biochemical and biophysical basis of visual transduction, makes it ideal for systems-level analysis. A sensitivity analysis is…”
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