Necrotizing granulomatous vasculitis associated with cocaine use

Cocaine abuse may be associated with a destructive nasal and pharyngeal process felt to be due to ischemia secondary to vasoconstriction. This report is the first to document a necrotizing granulomatous vasculitis associated with nasal destruction and an oronasal fistula in a chronic cocaine user. C...

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Bibliographic Details
Published in:	Journal of rheumatology Vol. 29; no. 8; pp. 1795 - 1797
Main Authors:	GERTNER, Elie, HAMLAR, Dave
Format:	Journal Article
Language:	English
Published:	Toronto, ON The Journal of Rheumatology 01-08-2002 Journal of Rheumatology Publishing
Subjects:	Biological and medical sciences Cocaine Cocaine-Related Disorders - complications Cocaine-Related Disorders - pathology Cocaine-Related Disorders - surgery Drug addictions Granuloma - chemically induced Granuloma - pathology Granuloma - surgery Humans Male Medical sciences Middle Aged Nasal Septum - drug effects Nasal Septum - pathology Nasal Septum - surgery Necrosis Non tumoral diseases Nose Diseases - chemically induced Nose Diseases - pathology Nose Diseases - surgery Oral Fistula - chemically induced Oral Fistula - pathology Oral Fistula - surgery Otorhinolaryngology. Stomatology Paranasal Sinuses - drug effects Paranasal Sinuses - pathology Paranasal Sinuses - surgery Toxicology Treatment Outcome Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Vasculitis - chemically induced Vasculitis - pathology Vasculitis - surgery Human Granulomatous vasculitis Drug addiction Necrotizing vasculitis Upper respiratory tract Respiratory disease Toxicity Cardiovascular disease Vascular disease Case study Ester ENT disease Adult Cocaine
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Summary:	Cocaine abuse may be associated with a destructive nasal and pharyngeal process felt to be due to ischemia secondary to vasoconstriction. This report is the first to document a necrotizing granulomatous vasculitis associated with nasal destruction and an oronasal fistula in a chronic cocaine user. Cocaine is an environmental insult that may play a role in triggering cerebral and non-cerebral vasculitis including a necrotizing granulomatous vasculitis of the respiratory tract.
ISSN:	0315-162X 1499-2752