Search Results - "HAMBOR, J. E"

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage by Mitchell, P G, Magna, H A, Reeves, L M, Lopresti-Morrow, L L, Yocum, S A, Rosner, P J, Geoghegan, K F, Hambor, J E

“…Proteolysis of triple-helical collagen is an important step in the progression toward irreversible tissue damage in osteoarthritis. Earlier work on the…”
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Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene by HAMBOR, J. E, MENNONE, J, COON, M. E, HANKE, J. H, KAVATHAS, P

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An Immunoregulatory Function for the CD8 Molecule by Kaplan, David R., Hambor, John E., Tykocinski, Mark L.

“…The molecular details of immunoregulatory phenomena associated with CD8+ T lymphocytes have not been clearly elucidated. We tested the hypothesis that the cell…”
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The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A by Chuang, Ellen, Fisher, Timothy S., Morgan, Rodney W., Robbins, Michael D., Duerr, James M., Vander Heiden, Matthew G., Gardner, Joseph P., Hambor, John E., Neveu, Mark J., Thompson, Craig B.

“…CD28 and CTLA-4 are related members of a family of T lymphocyte cell surface receptors that function to regulate T cell activation. We have found that the…”
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Use of an Epstein-Barr Virus Episomal Replicon for Anti-Sense RNA-Mediated Gene Inhibition in a Human Cytotoxic T-Cell Clone by Hambor, John E., Hauer, Christopher A., Shu, Hui-Kuo, Groger, Richard K., Kaplan, David R., Tykocinski, Mark L.

“…A methodology was developed for stable gene transfer into cloned nontransformed human T lymphocytes. Stable high-level gene expression was achieved in cloned…”
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CD8 functions as an inhibitory ligand in mediating the immunoregulatory activity of CD8+ cells by Hambor, JE, Kaplan, DR, Tykocinski, ML

“…Antisense and sense transfection technologies were employed in cellular coculture systems to investigate the physiologic requirements for CD8-dependent…”
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Regulation of Cytotoxic T Lymphocyte-Associated Molecule-4 by Src Kinases by Chuang, Ellen, Lee, Kyung-Mi, Robbins, Michael D, Duerr, James M, Alegre, Maria-Luisa, Hambor, John E, Neveu, Mark J, Bluestone, Jeffrey A, Thompson, Craig B

“…Cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) is a cell surface receptor expressed on activated T cells that can inhibit T cell responses induced by…”
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Assembly and regulation of the CD40 receptor complex in human B cells by Kuhné, M R, Robbins, M, Hambor, J E, Mackey, M F, Kosaka, Y, Nishimura, T, Gigley, J P, Noelle, R J, Calderhead, D M

“…CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily. Studies with human B cells show that the binding of CD154 (gp39, CD40L) to CD40…”
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Cloning, sequencing and characterization of the 5'-flanking region of the human collagenase-3 gene by Tardif, G, Pelletier, J P, Dupuis, M, Hambor, J E, Martel-Pelletier, J

“…Collagenase-3 (matrix metalloprotease-13) is a recently discovered human collagenase produced in normal articular cartilage chondrocytes and thought to be…”
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Regulation of allogeneic responses by expression of CD8 alpha chain on stimulator cells by Hambor, J E, Weber, M C, Tykocinski, M L, Kaplan, D R

“…By antisense-mediated inhibition of CD8 expression in T cell clones and expression of CD8 in non-T cell lines, we have produced several sets of CD8+/CD8-…”
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Functional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone by HAMBOR, J. E, TYKOCINSKI, M. L, KAPLAN, D. R

“…An experimental approach for defining the function of CD8 has been developed by linking anti-sense RNA mutagenesis and T cell cloning technologies. We have…”
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Repetitive Alu elements form a cruciform structure that regulates the function of the human CD8 alpha T cell-specific enhancer by Hanke, J H, Hambor, J E, Kavathas, P

“…We previously identified a T cell-specific enhancer in the last intron of the human CD8 alpha gene that is adjacent to a sequence element that significantly…”
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Impairment of macrophage migration inhibitory factor synthesis and macrophage migration in protein-malnourished mice by Hambor, J E, Fleck, L, Stevenson, J R

“…Weanling CD2F1 mice were fed isocaloric diets that were protein sufficient (PS; containing 27% casein) or protein deficient (PD; containing 8% casein). Weight…”
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Impaired Inflammatory and Pain Responses in Mice Lacking an Inducible Prostaglandin E Synthase by Trebino, Catherine E., Stock, Jeffrey L., Gibbons, Colleen P., Naiman, Brian M., Wachtmann, Timothy S., Umland, John P., Pandher, Karamjeet, Lapointe, Jean-Martin, Saha, Sipra, Roach, Marsha L., Carter, Demetrius, Thomas, Nathalie A., Durtschi, Becky A., McNeish, John D., Hambor, John E., Jakobsson, Per-Johan, Carty, Thomas J., Perez, Jose R., Audoly, Laurent P.

“…Prostaglandin (PG)E2is a potent mediator of pain and inflammation, and high levels of this lipid mediator are observed in numerous disease states. The…”
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Human T-Cell Leukemia Virus Type 1 Tax Induction of NF-κB Involves Activation of the IκB Kinase α (IKKα) and IKKβ Cellular Kinases by Geleziunas, Romas, Ferrell, Sharon, Lin, Xin, Mu, Yajun, Cunningham, Emmett T., Grant, Mark, Connelly, Margery A., Hambor, John E., Marcu, Kenneth B., Greene, Warner C.

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Embryonic Stem Cells in Predictive Cardiotoxicity: Laser Capture Microscopy Enables Assay Development by Chaudhary, Khuram W., Barrezueta, Nestor X., Bauchmann, Mary B., Milici, Anthony J., Beckius, Gretchen, Stedman, Donald B., Hambor, John E., Blake, William L., McNeish, John D., Bahinski, Anthony, Cezar, Gabriela Gebrin

“…Embryonic stem (ES) cells offer unprecedented opportunities for in vitro drug discovery and safety assessment of compounds. Cardiomyocytes derived from ES…”
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Activation and regulation of the IkappaB kinase in human B cells by CD40 signaling by Kosaka, Y, Calderhead, D M, Manning, E M, Hambor, J E, Black, A, Geleziunas, R, Marcu, K B, Noelle, R J

“…This study demonstrates that the engagement of CD40 results in the activation of the recently described IkappaB kinase (IKK) in a human B cell line. The kinase…”
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases by Geleziunas, R, Ferrell, S, Lin, X, Mu, Y, Cunningham, Jr, E T, Grant, M, Connelly, M A, Hambor, J E, Marcu, K B, Greene, W C

“…Tax corresponds to a 40-kDa transforming protein from the pathogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) that activates nuclear expression…”
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Activation and regulation of the IκB kinase in human B cells by CD40 signaling by Kosaka, Yoko, Calderhead, David M., Manning, Eric M., Hambor, John E., Black, Amelia, Geleziunas, Romas, Marcu, Kenneth B., Noelle, Randolph J.

“…This study demonstrates that the engagement of CD40 results in the activation of the recently described IκB kinase (IKK) in a human B cell line. The kinase…”
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Use of an Epstein-Barr virus episomal replicon for antisense RNA-mediated gene inhibition in a human cytotoxic T-cell clone by HAMBOR, J. E, HAUER, C. A, HUI-KUO SHU, GROGER, R. K, KAPLAN, D. R, TYKOCINSKI, M. L

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