Search Results - "HAMAURA, TAKESHI"

Evaluation of solid dispersions on a molecular level by the Raman mapping technique by Furuyama, Naho, Hasegawa, Susumu, Hamaura, Takeshi, Yada, Shuichi, Nakagami, Hiroaki, Yonemochi, Etsuo, Terada, Katsuhide

“…Troglitazone containing two asymmetric carbons has four isomers. Crystalline troglitazone consists of two crystalline diastereomer-pairs, RR/SS and RS/SR,…”
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Prediction of recrystallization behavior of troglitazone/polyvinylpyrrolidone solid dispersion by solid-state NMR by Ito, Atsutoshi, Watanabe, Tomoyuki, Yada, Shuichi, Hamaura, Takeshi, Nakagami, Hiroaki, Higashi, Kenjirou, Moribe, Kunikazu, Yamamoto, Keiji

“…The purpose of this study was to elaborate the relationship between the 13C CP/MAS NMR spectra and the recrystallization behavior during the storage of…”
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Effects of water content in physical mixture and heating temperature on crystallinity of troglitazone-PVP K30 solid dispersions prepared by closed melting method by Hasegawa, Susumu, Hamaura, Takeshi, Furuyama, Naho, Kusai, Akira, Yonemochi, Etsuo, Terada, Katsuhide

“…Troglitazone, which possesses two asymmetric carbons, is obtained as a mixture of four isomers present in equal amounts. Troglitazone (Lot T003) has two…”
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Do Amorphous Troglitazones Prepared from Two Diastereomer-Pairs Have the Same Molecular Mobility and Crystallization Rate at the Surface? by Furuyama, Naho, Hasegawa, Susumu, Yada, Shuichi, Hamaura, Takeshi, Wakiyama, Naoki, Yonemochi, Etsuo, Terada, Katsuhide, Buckton, Graham

“…The surface of amorphous compounds crystallizes faster compared to the bulk. This suggests that molecules at the surface have high molecular mobility…”
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Solid phase transition of CS-891 enantiotropes during grinding by Yada, Shuichi, Ohya, Masaoki, Ohuchi, Yuko, Hamaura, Takeshi, Wakiyama, Naoki, Usui, Fusao, Kusai, Akira, Yamamoto, Keiji

“…The physical properties of N-[1-(4-methoxyphenyl)-1-methylethyl]-3-oxo-4-aza-5a-androst-1-ene-17β-carboxamide (CS-891), a novel and orally effective…”
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Effect of physical properties of troglitazone crystal on the molecular interaction with PVP during heating by Hasegawa, Susumu, Furuyama, Naho, Yada, Shuichi, Hamaura, Takeshi, Kusai, Akira, Yonemochi, Etsuo, Terada, Katsuhide

“…This study examined the effect of physical properties of troglitazone drug substance on the molecular interaction with polyvinylpyrrolidone K30 (PVP) during…”
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Measurement of agitation force in dissolution test and mechanical destructive force in disintegration test by Kamba, Masaharu, Seta, Yasuo, Takeda, Nao, Hamaura, Takeshi, Kusai, Akira, Nakane, Hisanori, Nishimura, Kenji

“…The purpose of this study was to investigate the effect of the agitation force and mechanical destructive force on the drug dissolution of a tablet in the…”
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Uniformity and physical states of troglitazone in solid dispersions determined by electron probe microanalysis and microthermal analysis by Hasegawa, Susumu, Hamaura, Takeshi, Furuyama, Naho, Horikawa, Samu, Kusai, Akira, Yonemochi, Etsuo, Terada, Katsuhide

“…Solid dispersions of troglitazone with PVP K30 in a weight ratio of 1:2 were prepared by the closed melting method. Solid dispersions that exhibit different…”
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Assessment of Pharmaceutical Excipient-Induced Gastrointestinal Mucosal Damage in Rats in Vivo by Measuring the Permeation of Phenolsulfonphthalein by NAKAMURA, JUNZO, TAKADA, SHIGEYUKI, UEDA, SATOSHI, HAMAURA, TAKESHI, YAMAMOTO, AKIRA, KIMURA, TOSHIKIRO, SEZAKI, HITOSHI

“…The effect of pharmaceutical excipients on the gastrointestinal mucosa in rats was examined by measuring the permeation of phenosulfonphthalein (phenol red), a…”
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Interaction between water and poly(vinylpyrrolidone) containing polyethylene glycol by Hamaura, T, Newton, J M

“…Information on the interaction between water and polymers is indispensable for manufacturing solid dispersion of a drug by hot-melt extrusion because this…”
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Effect of temperature on intestinal transfer and tissue uptake of sulfanilamide and aminopropyron in vitro by Hamaura, T, Nakane, S, Hashida, M, Sezaki, H

“…The effect of temperature on the transfer and the tissue uptake of sulfanilamide and aminopropyron, an aminopyrine derivative, was investigated using the…”
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Immunological control of drug absorption from the gastrointestinal tract: effect of local anaphylaxis on the intestinal absorption of low molecular weight drugs in the rat by Yamamoto, A, Utsumi, E, Hamaura, T, Nakamura, J, Hashida, M, Sezaki, H

“…Intestinal absorption of various drugs was examined by means of in situ recirculation technique during local anaphylaxis. The antibody was determined by…”
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An assessment of gastric ulcers in vivo: enhancement of urinary recovery after oral administration of phenolsulfonphthalein in rats by Nakamura, J, Takada, S, Ohtsuka, N, Heya, T, Ueda, S, Hamaura, T, Yamamoto, A, Kimura, T, Sezaki, H

“…The permeability of gastric wall barrier to phenolsulfonphthalein (phenol red), a poorly absorbed drug, was examined as an index of an assessment of gastric…”
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Changes in D-glucose uptake by brush-border vesicles from small intestine of rats treated with mitomycin C by Mizuno, M, Hamaura, T, Hashida, M, Sezaki, H

“…The effect of mitomycin C pre-administration on the D-glucose transport system in the intestinal brush-border membrane of rat small intestine was examined by a…”
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Characterization of mitomycin C-induced gastrointestinal damage. I. In situ recirculation experiment by Mizuno, M, Kawabata, S, Hamaura, T, Hashida, M, Sezaki, H

“…The effects of mitomycin C (MMC), an anti-tumor agent, on the intestinal absorption of various drugs in rats were investigated. Based on microscopic…”
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Characterization of mitomycin C-induced gastrointestinal damage. II. In vitro everted sac experiment by Hamaura, T, Mizuno, M, Nakane, S, Hashida, M, Sezaki, H

“…The everted gut sac technique was employed to clarify the effects of preadministration of mitomycin C (MMC) on intestinal transport of various drugs. Loss of…”
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Immunological control of drug absorption from the gastrointestinal tract: the mechanism whereby intestinal anaphylaxis interferes with the intestinal absorption of bromthymol blue in the rat by Yamamoto, A, Utsumi, E, Sakane, T, Hamaura, T, Nakamura, J, Hashida, M, Sezaki, H

“…Rats were immunized intraperitoneally with ovalbumin and the disappearance of bromthymol blue (BTB) from the intestinal lumen, its accumulation in the tissue,…”
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