Search Results - "HALMES, N. Christine"

Evidence-based toxicology: a comprehensive framework for causation by Guzelian, Philip S, Victoroff, Michael S, Halmes, N Christine, James, Robert C, Guzelian, Christopher P

“…This paper identifies deficiencies in some current practices of causation and risk evaluation by toxicologists and formulates an evidence-based solution. The…”
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Protein targets of xenobiotic reactive intermediates by Pumford, N R, Halmes, N C

“…Many xenobiotics are metabolically activated to electrophilic intermediates that form covalent adducts with proteins; the mechanism of toxicity is either…”
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Covalent Binding of Xenobiotics to Specific Proteins in the Liver by Pumford, Neil R., Halmes, N. Christine, Hinson, Jack A.

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Reevaluating cancer risk estimates for short-term exposure scenarios by HALMES, N. Christine, ROBERTS, Stephen M, TOLSON, J. Keith, PORTIER, Christopher J

“…Estimates of cancer risk from short-term exposure to carcinogens generally rely on cancer potency values derived from chronic, lifetime-exposure studies and…”
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Immunochemical detection of oxidized proteins by Keller, Randal J, Halmes, N. Christine, Hinson, Jack A, Pumford, Neil R

“…An immunochemical assay was developed to detect carbonyl moieties that result from oxidative damage to proteins. Bovine serum albumin was reacted with hydroxyl…”
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Glutamate Dehydrogenase Covalently Binds to a Reactive Metabolite of Acetaminophen by Halmes, N. Christine, Hinson, Jack A, Martin, Brian M, Pumford, Neil R

“…The mechanism of the hepatotoxicity of the analgesic acetaminophen is believed to be mediated by covalent binding to protein; however, critical targets which…”
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Immunochemical Detection of Protein Adducts in Mice Treated with Trichloroethylene by Halmes, N. Christine, McMillan, David C, Oatis, John E, Pumford, Neil R

“…Trichloroethylene has been shown to produce tumors in rodents and is a suspect human carcinogen. In addition, a number of case reports raise the possibility…”
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The acetaminophen regioisomer 3′-hydroxyacetanilide inhibits and covalently binds to cytochrome P450 2E1 by Halmes, N.Christine, Samokyszyn, Victor M, Hinton, Thomas W, Hinson, Jack A, Pumford, Neil R

“…3′-Hydroxyacetanilide has been previously studied as a nontoxic regioisomer of the analgesic acetaminophen (4′-hydroxyacetanilide). The radiolabeled derivative…”
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Detection of trichloroethylene-protein adducts in rat liver and plasma by Halmes, N.Christine, Perkins, Everett J., McMillan, David C., Pumford, Neil R.

“…Trichloroethylene is an industrial chemical with widespread occupational exposure and is a major environmental contaminant. In a Western blot using antiserum…”
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Immunochemical detection of drug-protein adducts in acetaminophen hepatotoxicity by Hinson, J A, Roberts, D W, Halmes, N C, Gibson, J D, Pumford, N R

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