Search Results - "HALLINAN, E ANN"

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates by Wang, Jane L., Aston, Karl, Limburg, David, Ludwig, Cindy, Hallinan, Ann E., Koszyk, Francis, Hamper, Bruce, Brown, David, Graneto, Matthew, Talley, John, Maziasz, Timothy, Masferrer, Jaime, Carter, Jeffery

“…Our objective described in this Letter was to discover selective inhibitors of COX-2 that were efficacious in animal models of inflammation and pain and that…”
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4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain by Hallinan, E Ann, Kramer, Steven W, Houdek, Stephen C, Moore, William M, Jerome, Gina M, Spangler, Dale P, Stevens, Anna M, Shieh, Huey S, Manning, Pamela T, Pitzele, Barnett S

“…In the literature, the introduction of fluorine into bioactive molecules has been known to enhance the biological activity relative to the parent molecule…”
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Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor by Hallinan, E Ann, Tsymbalov, Sofya, Dorn, Clifford R, Pitzele, Barnett S, Hansen, Jr, Donald W, Moore, William M, Jerome, Gina M, Connor, Jane R, Branson, Linda F, Widomski, Deborah L, Zhang, Yan, Currie, Mark G, Manning, Pamela T

“…The 5-tetrazole amide of L-N(6)-(1-iminoethyl)lysine (L-NIL), L-N(6)-(1-iminoethyl)lysine 5-tetrazole amide (1), has been prepared and evaluated. In contrast…”
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5-Fluorinated l-Lysine Analogues as Selective Induced Nitric Oxide Synthase Inhibitors by Hallinan, E. Ann, Hagen, Timothy J, Bergmanis, Arija, Moore, William M, Jerome, Gina M, Spangler, Dale P, Stevens, Anna M, Shieh, Huey S, Manning, Pamela T, Pitzele, Barnett S

“…5(S)-Fluoro-N6-(iminoethyl)-l -lysine ( 14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was…”
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Synthesis and properties of 7,7-difluoro derivatives of the 2,6-dioxa[3.1.1]bicycloheptane ring system present in thromboxane A2 by Fried, Josef, Hallinan, E. Ann, Szwedo, Mitchell J

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3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: A potent and highly selective inducible nitric oxide synthase inhibitor by Tsymbalov, Sofya, Hagen, Timothy J., Moore, William M., Jerome, Gina M., Connor, Jane R., Manning, Pamela T., Pitzele, Barnett S., Hallinan, E.Ann

“…(3 S,4 S,5 R)-2-Imino-4-methyl-5-pentyl-3-pyrrolidinol hydrochloride ( 1) is a potent inducible nitric oxide synthase (i-NOS) inhibitor that has three times…”
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Synthesis and Biological Characterization of L-N6-(1-Iminoethyl)lysine 5-Tetrazole-amide, a Prodrug of a Selective iNOS Inhibitor by Hallinan, E. Ann, Tsymbalov, Sofya, Dorn, Clifford R, Pitzele, Barnett S, Hansen, Donald W, Moore, William M, Jerome, Gina M, Connor, Jane R, Branson, Linda F, Widomski, Deborah L, Zhang, Yan, Currie, Mark G, Manning, Pamela T

“…The 5-tetrazole amide of L-N6-(1-iminoethyl)lysine (L-NIL), L-N6-(1-iminoethyl)lysine 5-tetrazole amide (1), has been prepared and evaluated. In contrast to…”
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Synthesis and Biological Characterization of L-N 6 -(1-Iminoethyl)lysine 5-Tetrazole-amide, a Prodrug of a Selective iNOS Inhibitor by Hallinan, E. Ann, Tsymbalov, Sofya, Dorn, Clifford R., Pitzele, Barnett S., Hansen, Donald W., Moore, William M., Jerome, Gina M., Connor, Jane R., Branson, Linda F., Widomski, Deborah L., Zhang, Yan, Currie, Mark G., Manning, Pamela T.

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Investigations of (4-cyanophenyl)ureas of sweet amino acids as potential sweeteners by Hallinan, E. Ann, Walters, D. Eric, DuBois, Grant E, Mazur, Robert H, Muller, George W

“…(4-Cyanophenyl)carbamoylglycine has a sweetness potency of 30 times sucrose and 20-fold higher than that of glycine itself We sought to determine whether the…”
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2,4-disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist by HALLINAN, E. Ann, HAGEN, Timothy J, TSYMBALOV, Sofya, STAPELFELD, Awilda, SAVAGE, Michael A

“…8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride (1, SC-51089) is a functional PGE2…”
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2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase by Hagen, Timothy J, Bergmanis, Arija A, Kramer, Steven W, Fok, Kam F, Schmelzer, Albert E, Pitzele, Barnett S, Swenton, Lydia, Jerome, Gina M, Kornmeier, Christine M, Moore, William M, Branson, Linda F, Connor, Jane R, Manning, Pamela T, Currie, Mark G, Hallinan, E. Ann

“…A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase…”
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Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE2 Antagonist, and Its Analogs by Hallinan, E. Ann, Hagen, Timothy J, Tsymbalov, Sofya, Husa, Robert K, Lee, Albert C, Stapelfeld, Awilda, Savage, Michael A

“…8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride (1, SC-51089) is a functional PGE2…”
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The synthesis of 6-trifluoroethyl- l-lysine: a method to introduce functionality at C-6 of l-lysine by Hallinan, E.Ann, Dorn, Clifford R., Moore, William M., Jerome, Gina M., Manning, Pamela T., Pitzele, Barnett S.

“…Described is a method of introducing trifluoroalkyl groups at C-6 of lysine. This chemistry has the potential to introduce a variety of functionality at C-6 of…”
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Acetamidine Lysine Derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide Dihydrochloride:  A Highly Selective Inhibitor of Human Inducible Nitric Oxide Synthase by Hallinan, E. Ann, Tsymbalov, Sofya, Finnegan, Patricia M, Moore, William M, Jerome, Gina M, Currie, Mark G, Pitzele, Barnett S

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N-Substituted dibenzoxazepines as analgesic PGE2 antagonists by Hallinan, E. Ann, Hagen, Timothy J, Husa, Robert K, Tsymbalov, Sofya, Rao, Shashidhar N, vanHoeck, Jean Pierre, Rafferty, Michael F, Stapelfeld, Awilda, Savage, Michael A, Reichman, Melvin

“…8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide (1, SC-19220) has been previously reported by us and others to be a PGE2…”
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Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE 2 Antagonist, and Its Analogs by Hallinan, E. Ann, Hagen, Timothy J., Tsymbalov, Sofya, Husa, Robert K., Lee, Albert C., Stapelfeld, Awilda, Savage, Michael A.

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STUDIES TOWARD THE SYNTHESIS OF 10,10-DIFLUOROTHROMBOXANE A(2) by HALLINAN, E ANN

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The N-Boc Group as an Activator for the a-Lithiation of Carbamates: Synthesis of 11-Substituted Dibenzoxazepines by J. Hagen, Timothy, F. Rafferty, Michael, T. Collins, Joe, J. Garland, Danny, J. Li, James, B. Norton, Monica, B. Reitz, David, Tsymbalov, Sofya, S. Pitzele, Barnett, Ann Hallinan, E.

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Formation of a dehydroalanyl residue from S-benzylcysteine upon HF cleavage of a [Sar1, Cys8]-angiotensin II peptide resin by Hallinan, E A

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Lithiation and electrophilic substitution of 8-chlorodibenz[b,f][1,4]-oxazepine-10-tert-butylcarbamate: The preparation of novel fused heterocyclic derivatives of 8-chlorodibenzoxazepine by Li, James J., Chrusciel, R. Alan, Norton, Monica B., Reitz, David B., Hagen, Timothy J., Tsymbalov, Sofya, Hallinan, E. Ann

“…Lithiation of 8‐chlorodibenz[b,f][1,4]oxazepine‐10‐tert‐butylcarbamate (1) is described. Electrophilic substitution of the resulting N‐Boc dibenzoxazepine α‐…”
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