Search Results - "HALFTER, Hartmut"

Idiopathic Hypersomnia Patients Revealed Longer Circadian Period Length in Peripheral Skin Fibroblasts by Materna, Linus, Halfter, Hartmut, Heidbreder, Anna, Boentert, Matthias, Lippert, Julian, Koch, Raphael, Young, Peter

“…The vast majority of living organisms have evolved a circadian rhythm of roughly 24 h in adaptation to ever-changing environmental conditions, such as the…”
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Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia by Lippert, Julian, Halfter, Hartmut, Heidbreder, Anna, Röhr, Dominik, Gess, Burkhard, Boentert, Mathias, Osada, Nani, Young, Peter

“…From single cell organisms to the most complex life forms, the 24-hour circadian rhythm is important for numerous aspects of physiology and behavior such as…”
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The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease by NIEMANN, Axel, HUBER, Nina, LAURA FELTRI, M, WRABETZ, Lawrence, YOUNG, Peter, WESSIG, Carsten, TOYKA, Klaus V, SUTER, Ueli, WAGNER, Konstanze M, SOMANDIN, Christian, HORN, Michael, LEBRUN-JULIEN, Frédéric, ANGST, Brigitte, PEREIRA, Jorge A, HALFTER, Hartmut, WELZL, Hans

“…The ganglioside-induced differentiation-associated protein 1 (GDAP1) is a mitochondrial fission factor and mutations in GDAP1 cause Charcot-Marie-Tooth…”
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Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system by Gess, Burkhard, Röhr, Dominik, Fledrich, Robert, Sereda, Michael W, Kleffner, Ilka, Humberg, Anne, Nowitzki, Johanna, Strecker, Jan-Kolja, Halfter, Hartmut, Young, Peter

“…Ascorbic acid (vitamin C) is necessary for myelination of Schwann cell/neuron cocultures and has shown beneficial effects in the treatment of a…”
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Bex1 is involved in the regeneration of axons after injury by Khazaei, Mohammad R, Halfter, Hartmut, Karimzadeh, Fereshteh, Koo, Jae Hyung, Margolis, Frank L, Young, Peter

“…J. Neurochem. (2010) 115, 910-920. ABSTRACT: Successful axonal regeneration is a complex process determined by both axonal environment and endogenous neural…”
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Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells by FANG ZHANG, CONG LI, HAIFTER, Hartmut, JINGWEN LIU

“…A number of studies have demonstrated that the STAT pathway is an important signaling cascade utilized by the IL-6 cytokine family to regulate a variety of…”
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High-Throughput Analysis of Genome-Wide Receptor Tyrosine Kinase Expression in Human Cancers Identifies Potential Novel Drug Targets by MÜLLER-TIDOW, Carsten, SCHWÄBLE, Joachim, SCHNEIDER, Paul M, BÜCHNER, Thomas, BRANDTS, Christian, BERDEL, Wolfgang E, SERVE, Hubert, STEFFEN, Björn, TIDOW, Nicola, BRANDT, Burkhardt, BECKER, Kerstin, SCHULZE-BAHR, Eric, HALFTER, Hartmut, VOGT, Ulf, METZGER, Ralf

“…Novel high-throughput analyses in molecular biology allow sensitive and rapid identification of disease-related genes and drug targets. We have used…”
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Varying survival of motoneurons and activation of distinct molecular mechanism in response to altered peripheral myelin protein 22 gene dosage by Nattkämper, Heiner, Halfter, Hartmut, Khazaei, Mohammad R, Lohmann, Tina, Gess, Burkhard, Eisenacher, Martin, Willscher, Edith, Young, Peter

“…Alteration in the expression level of peripheral myelin protein 22 (PMP22) is the most frequent cause for demyelinating neuropathies of Charcot-Marie-Tooth…”
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Sodium-dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L-ascorbic acid into Schwann cells by Gess, Burkhard, Lohmann, Christina, Halfter, Hartmut, Young, Peter

“…Ascorbic acid has been shown to be an essential component for in vitro myelination and to improve the clinical and pathological phenotype of a mouse model of…”
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HSJ1-related hereditary neuropathies: Novel mutations and extended clinical spectrum by Gess, Burkhard, Auer-Grumbach, Michaela, Schirmacher, Anja, Strom, Tim, Zitzelsberger, Manuela, Rudnik-Schöneborn, Sabine, Röhr, Dominik, Halfter, Hartmut, Young, Peter, Senderek, Jan

“…OBJECTIVES:To determine the nature and frequency of HSJ1 mutations in patients with hereditary motor and hereditary motor and sensory neuropathies…”
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Growth inhibition of newly established human glioma cell lines by leukemia inhibitory factor by HALFTER, H, KREMERSKOTHEN, J, WEBER, J, HACKER-KLOM, U, BARNEKOW, A, RINGELSTEIN, E. B, STÖGBAUER, F

“…We have established three new cell lines deriving from malignant human gliomas. The cell lines were described in terms of both morphology and growth…”
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Sodium‐dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation by Röhr, Dominik, Halfter, Hartmut, Schulz, Jörg B., Young, Peter, Gess, Burkhard

“…Peripheral nerve myelination involves rapid production of tightly bound lipid layers requiring cholesterol biosynthesis and myelin protein expression, but also…”
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Mutations in SEPT9 cause hereditary neuralgic amyotrophy by Jonghe, Peter De, Goossens, Dirk, Kurlemann, Gert, Mononen, Tarja, Nelis, Eva, Ringelstein, E Bernd, Schirmacher, Anja, Prats, José M, Bird, Thomas D, Kuhlenbäumer, Gregor, Stögbauer, Florian, Meuleman, Jan, Young, Peter, Del-Favero, Jurgen, Broeckhoven, Christine Van, Irobi, Joy, Betz, Benjamin G, Hannibal, Mark C, Watts, Giles D J, Timmerman, Vincent, Serradell, Adolfo Pou, Vriendt, Els De, Airaksinen, Eila, Hor, Hyun, Halfter, Hartmut, Chance, Phillip F, Verpoorten, Nathalie

“…Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant recurrent neuropathy affecting the brachial plexus. HNA is triggered by environmental factors…”
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Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways by Mizuki, Masao, Fenski, Regina, Halfter, Hartmut, Matsumura, Itaru, Schmidt, Rainer, Müller, Carsten, Grüning, Wolfram, Kratz-Albers, Karsten, Serve, Susanne, Steur, Claudia, Büchner, Thomas, Kienast, Joachim, Kanakura, Yuzuru, Berdel, Wolfgang E., Serve, Hubert

“…Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications (ITD) occur in 20% of patients with acute myeloid leukemia…”
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Activation of Jak-Stat and MAPK2 Pathways by Oncostatin M Leads to Growth Inhibition of Human Glioma Cells by Halfter, Hartmut, Friedrich, Matthias, Postert, Christiane, Bernd Ringelstein, E, Stögbauer, Florian

“…Oncostatin M (OSM) is a cytokine of the IL-6 family that modulates the growth of various cell types, at least in vitro. We have recently described that OSM…”
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E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles by Young, Peter, Boussadia, Oreda, Halfter, Hartmut, Grose, Richard, Berger, Philipp, Leone, Dino P., Robenek, Horst, Charnay, Patrick, Kemler, Rolf, Suter, Ueli

“…E‐cadherin is thought to mediate intercellular adhesion in the mammalian epidermis and in hair follicles as the adhesive component of adherens junctions. We…”
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Autosomal-Dominant Striatal Degeneration Is Caused by a Mutation in the Phosphodiesterase 8B Gene by Appenzeller, Silke, Schirmacher, Anja, Halfter, Hartmut, Bäumer, Sebastian, Pendziwiat, Manuela, Timmerman, Vincent, De Jonghe, Peter, Fekete, Klára, Stögbauer, Florian, Lüdemann, Peter, Hund, Margret, Quabius, Elgar Susanne, Ringelstein, E. Bernd, Kuhlenbäumer, Gregor

“…Autosomal-dominant striatal degeneration (ADSD) is an autosomal-dominant movement disorder affecting the striatal part of the basal ganglia. ADSD is…”
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Inhibition of N-cadherin and β-catenin function reduces axon-induced Schwann cell proliferation by Gess, Burkhard, Halfter, Hartmut, Kleffner, Ilka, Monje, Paula, Athauda, Gagani, Wood, Patrick M., Young, Peter, Wanner, Ina B.

“…N‐cadherin and β‐catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC)…”
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Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression by HALFTER, Hartmut, FRIEDRICH, Matthias, RESCH, Ansgar, KULLMANN, Michael, STÖGBAUER, Florian, BERND RINGELSTEIN, E, HENGST, Ludger

“…Oncostatin M has been characterized as a potent growth inhibitor for various tumor cells. Oncostatin M-treated glioblastoma cells cease proliferation and…”
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Altered Dynamics in the Circadian Oscillation of Clock Genes in Dermal Fibroblasts of Patients Suffering from Idiopathic Hypersomnia: e85255 by Lippert, Julian, Halfter, Hartmut, Heidbreder, Anna, Rohr, Dominik, Gess, Burkhard, Boentert, Mathias, Osada, Nani, Young, Peter

“…From single cell organisms to the most complex life forms, the 24-hour circadian rhythm is important for numerous aspects of physiology and behavior such as…”
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