Search Results - "HALEY, S"

The heritability of human disease: estimation, uses and abuses by Tenesa, Albert, Haley, Chris S.

“…Key Points Most human diseases are dichotomous and are measured on a binary scale (disease absent (0) or present (1)). Some of the observed phenotypic…”
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Detecting epistasis in human complex traits by Wei, Wen-Hua, Hemani, Gibran, Haley, Chris S.

“…Key Points Tremendous activity in the development of methodology has now rendered the exhaustive search for pairwise genetic interactions computationally…”
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Seeing Blue Dots After COVID-19 Infection by D'Souza, Haley S, Tailor, Prashant D, Olsen, Timothy W

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Esophageal Adenocarcinoma Metastatic to the Choroid with Extrascleral Extension by D’Souza, Haley S., Dalvin, Lauren A., Wagner, Lilly H.

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Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits by Tatti, Roberta, Haley, Melissa S, Swanson, Olivia K, Tselha, Tenzin, Maffei, Arianna

“…Abstract Brain function relies on the ability of neural networks to maintain stable levels of activity, while experiences sculpt them. In the neocortex, the…”
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Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL by Lyon, A. R., Babalis, D., Morley-Smith, A. C., Hedger, M., Suarez Barrientos, A., Foldes, G., Couch, L. S., Chowdhury, R. A., Tzortzis, K. N., Peters, N. S., Rog-Zielinska, E. A., Yang, H-Y, Welch, S., Bowles, C. T., Rahman Haley, S., Bell, A. R., Rice, A., Sasikaran, T., Johnson, N. A., Falaschetti, E., Parameshwar, J., Lewis, C., Tsui, S., Simon, A., Pepper, J., Rudy, J. J., Zsebo, K. M., Macleod, K. T., Terracciano, C. M., Hajjar, R. J., Banner, N., Harding, S. E.

“…The SERCA-LVAD trial was a phase 2a trial assessing the safety and feasibility of delivering an adeno-associated vector 1 carrying the cardiac isoform of the…”
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Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways by Piñol, Ramón A., Mogul, Allison S., Hadley, Colleen K., Saha, Atreyi, Li, Chia, Škop, Vojtěch, Province, Haley S., Xiao, Cuiying, Gavrilova, Oksana, Krashes, Michael J., Reitman, Marc L.

“…The preoptic area (POA) is a key brain region for regulation of body temperature (Tb), dictating thermogenic, cardiovascular, and behavioral responses that…”
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Feasibility of an Opioid Sparing Discharge Protocol Following Laparoscopic Bariatric Surgery by Lehman, Haley S., Diaz, Sarah, Dandalides, Alissa, Carlin, Arthur M.

“…Background Opioids are commonly prescribed after laparoscopic bariatric surgery but have untoward effects including dependence and diversion. Prior…”
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Phosphonate utilization by the globally important marine diazotroph Trichodesmium by Chappell, P. D, Moffett, J. W, Haley, S. T, Waterbury, J. B, Orchard, E. D, Dyhrman, S. T, Webb, E. A

“…The factors that control the growth and nitrogen fixation rates of marine diazotrophs such as Trichodesmium have been intensively studied because of the role…”
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Vision of the future: large language models in ophthalmology by Tailor, Prashant D, D'Souza, Haley S, Li, Hanzhou, Starr, Matthew R

“…Large language models (LLMs) are rapidly entering the landscape of medicine in areas from patient interaction to clinical decision-making. This review…”
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Application of high-dimensional feature selection: evaluation for genomic prediction in man by Bermingham, M. L., Pong-Wong, R., Spiliopoulou, A., Hayward, C., Rudan, I., Campbell, H., Wright, A. F., Wilson, J. F., Agakov, F., Navarro, P., Haley, C. S.

“…In this study, we investigated the effect of five feature selection approaches on the performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction…”
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Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice by Richardson, Nicole E., Konon, Elizabeth N., Schuster, Haley S., Mitchell, Alexis T., Boyle, Colin, Rodgers, Allison C., Finke, Megan, Haider, Lexington R., Yu, Deyang, Flores, Victoria, Pak, Heidi H., Ahmad, Soha, Ahmed, Sareyah, Radcliff, Abigail, Wu, Jessica, Williams, Elizabeth M., Abdi, Lovina, Sherman, Dawn S., Hacker, Timothy A., Lamming, Dudley W.

“…Protein-restricted diets promote health and longevity in many species. While the precise components of a protein-restricted diet that mediate the beneficial…”
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VviERF6Ls: an expanded clade in Vitis responds transcriptionally to abiotic and biotic stresses and berry development by Toups, Haley S, Cochetel, Noé, Gray, Dennis, Cramer, Grant R

“…VviERF6Ls are an uncharacterized gene clade in Vitis with only distant Arabidopsis orthologs. Preliminary data indicated these transcription factors may play a…”
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Genomic analysis of family data reveals additional genetic effects on intelligence and personality by Hill, W. David, Arslan, Ruben C., Xia, Charley, Luciano, Michelle, Amador, Carmen, Navarro, Pau, Hayward, Caroline, Nagy, Reka, Porteous, David J., McIntosh, Andrew M., Deary, Ian J., Haley, Chris S., Penke, Lars

“…Pedigree-based analyses of intelligence have reported that genetic differences account for 50–80% of the phenotypic variation. For personality traits these…”
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Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing by Zhang, Qian, Vallerga, Costanza L, Walker, Rosie M, Lin, Tian, Henders, Anjali K, Montgomery, Grant W, He, Ji, Fan, Dongsheng, Fowdar, Javed, Kennedy, Martin, Pitcher, Toni, Pearson, John, Halliday, Glenda, Kwok, John B, Hickie, Ian, Lewis, Simon, Anderson, Tim, Silburn, Peter A, Mellick, George D, Harris, Sarah E, Redmond, Paul, Murray, Alison D, Porteous, David J, Haley, Christopher S, Evans, Kathryn L, McIntosh, Andrew M, Yang, Jian, Gratten, Jacob, Marioni, Riccardo E, Wray, Naomi R, Deary, Ian J, McRae, Allan F, Visscher, Peter M

“…DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from…”
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Epigenetic prediction of complex traits and death by McCartney, Daniel L, Hillary, Robert F, Stevenson, Anna J, Ritchie, Stuart J, Walker, Rosie M, Zhang, Qian, Morris, Stewart W, Bermingham, Mairead L, Campbell, Archie, Murray, Alison D, Whalley, Heather C, Gale, Catharine R, Porteous, David J, Haley, Chris S, McRae, Allan F, Wray, Naomi R, Visscher, Peter M, McIntosh, Andrew M, Evans, Kathryn L, Deary, Ian J, Marioni, Riccardo E

“…Genome-wide DNA methylation (DNAm) profiling has allowed for the development of molecular predictors for a multitude of traits and diseases. Such predictors…”
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Drought tolerance of the grapevine, Vitis champinii cv. Ramsey, is associated with higher photosynthesis and greater transcriptomic responsiveness of abscisic acid biosynthesis and signaling by Cochetel, Noé, Ghan, Ryan, Toups, Haley S, Degu, Asfaw, Tillett, Richard L, Schlauch, Karen A, Cramer, Grant R

“…Grapevine is an economically important crop for which yield and berry quality is strongly affected by climate change. Large variations in drought tolerance…”
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RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice by Turner, Kyrah L, Morris, Haley S, Awinda, Peter O, Fitzsimons, Daniel P, Tanner, Bertrand C W

“…Hypertrophic cardiomyopathy (HCM) is the leading genetic cause of heart disease. The heart comprises several proteins that work together to properly facilitate…”
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Bioinspired Diversification Approach Toward the Total Synthesis of Lycodine-Type Alkaloids by Haley, Hannah M. S, Payer, Stefan E, Papidocha, Sven M, Clemens, Simon, Nyenhuis, Jonathan, Sarpong, Richmond

“…Nitrogen heterocycles (azacycles) are common structural motifs in numerous pharmaceuticals, agrochemicals, and natural products. Many powerful methods have…”
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Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS) by Fernandez-Pujals, Ana Maria, Adams, Mark James, Thomson, Pippa, McKechanie, Andrew G, Blackwood, Douglas H R, Smith, Blair H, Dominiczak, Anna F, Morris, Andrew D, Matthews, Keith, Campbell, Archie, Linksted, Pamela, Haley, Chris S, Deary, Ian J, Porteous, David J, MacIntyre, Donald J, McIntosh, Andrew M

“…The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently,…”
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