Search Results - "HALEY, JOHN D."

Kinetics and Mechanism of Mammalian Mitochondrial Ribosome Assembly by Bogenhagen, Daniel F., Ostermeyer-Fay, Anne G., Haley, John D., Garcia-Diaz, Miguel

“…Mammalian mtDNA encodes only 13 proteins, all essential components of respiratory complexes, synthesized by mitochondrial ribosomes. Mitoribosomes contain…”
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Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease by Gujarati, Nehaben A., Frimpong, Bismark O., Zaidi, Malaika, Bronstein, Robert, Revelo, Monica P., Haley, John D., Kravets, Igor, Guo, Yiqing, Mallipattu, Sandeep K.

“…Diabetic kidney disease (DKD) is the main cause of chronic kidney disease worldwide. While injury to the podocytes, visceral epithelial cells that comprise the…”
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Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase by Pasquini, Miriam, Grosjean, Nicolas, Hixson, Kim K., Nicora, Carrie D., Yee, Estella F., Lipton, Mary, Blaby, Ian K., Haley, John D., Blaby-Haas, Crysten E.

“…The evolution of zinc (Zn) as a protein cofactor altered the functional landscape of biology, but dependency on Zn also created an Achilles’ heel,…”
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The HSP-RTK-Akt axis mediates acquired resistance to Ganetespib in HER2-positive breast cancer by Eyermann, Christopher E., Haley, John D., Alexandrova, Evguenia M.

“…Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20%…”
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Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans by Min, Kyunghun, Jannace, Thomas F, Si, Haoyu, Veeramah, Krishna R, Haley, John D, Konopka, James B

“…Microbial pathogens grow in a wide range of different morphologies that provide distinct advantages for virulence. In the fungal pathogen Candida albicans ,…”
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Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy by Thomson, Stuart, Petti, Filippo, Sujka-Kwok, Izabela, Epstein, David, Haley, John D.

“…NSCLC cells with a mesenchymal phenotype have shown a marked reduction in sensitivity to EGFR inhibitors, though the molecular rationale has remained obscure…”
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Comparative gene co-expression network analysis of epithelial to mesenchymal transition reveals lung cancer progression stages by Wang, Daifeng, Haley, John D, Thompson, Patricia

“…The epithelial to mesenchymal transition (EMT) plays a key role in lung cancer progression and drug resistance. The dynamics and stability of gene expression…”
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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib by CAREY, Kendall D, GARTON, Andrew J, ROMERO, Maria S, KAHLER, Jennifer, THOMSON, Stuart, ROSS, Sarajane, PARK, Frances, HALEY, John D, GIBSON, Neil, SLIWKOWSKI, Mark X

“…We show that two commonly occurring epidermal growth factor receptor (EGFR) somatic mutations, L858R and an in-frame deletion mutant, Del(746-750), exhibit…”
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Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition by THOMSON, Stuart, BUCK, Elizabeth, PETTI, Filippo, GRIFFIN, Graeme, BROWN, Eric, RAMNARINE, Nishal, IWATA, Kenneth K, GIBSON, Neil, HALEY, John D

“…Treatment of second- and third-line patients with non-small-cell lung carcinoma (NSCLC) with the epidermal growth factor receptor (EGFR) kinase inhibitor…”
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De novo lipogenesis represents a therapeutic target in mutant Kras non‐small cell lung cancer by Singh, Anju, Ruiz, Christian, Bhalla, Kavita, Haley, John A., Li, Qing Kay, Acquaah‐Mensah, George, Montal, Emily, Sudini, Kuladeep R., Skoulidis, Ferdinandos, Wistuba, Ignacio I., Papadimitrakopoulou, Vassiliki, Heymach, John V., Boros, Laszlo G., Gabrielson, Edward, Carretero, Julian, Wong, Kwok‐Kin, Haley, John D., Biswal, Shyam, Girnun, Geoffrey D.

“…ABSTRACT Oncogenic Kras mutations are one of the most common alterations in non‐small cell lung cancer and are associated with poor response to treatment and…”
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Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes by Xu, Huanzhou, Perez, Ramon D, Frey, Tiffany R, Burton, Eric M, Mannemuddhu, Sudha, Haley, John D, McIntosh, Michael T, Bhaduri-McIntosh, Sumita

“…Epstein-Barr virus (EBV) is an oncogenic herpesvirus and WHO class 1 carcinogen that resides in B lymphocytes of nearly all humans. While silent in most, EBV…”
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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors by Buck, Elizabeth, Eyzaguirre, Alexandra, Rosenfeld-Franklin, Maryland, Thomson, Stuart, Mulvihill, Mark, Barr, Sharon, Brown, Eric, O'Connor, Mathew, Yao, Yan, Pachter, Jonathan, Miglarese, Mark, Epstein, David, Iwata, Kenneth K, Haley, John D, Gibson, Neil W, Ji, Qun-Sheng

“…Epidermal growth factor receptor (EGFR) and insulin-like growth factor-I receptor (IGF-IR) can cooperate to regulate tumor growth and survival, and synergistic…”
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Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors by Buck, Elizabeth, Eyzaguirre, Alexandra, Brown, Eric, Petti, Filippo, McCormack, Siobhan, Haley, John D, Iwata, Kenneth K, Gibson, Neil W, Griffin, Graeme

“…The receptor for epidermal growth factor (EGFR) is overexpressed in many cancers. One important signaling pathway regulated by EGFR is the phosphatidylinositol…”
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AACR Special Conference on Epithelial-Mesenchymal Transition and Cancer Progression and Treatment by ROUSSOS, Evanthia T, KECKESOVA, Zuzana, HALEY, John D, EPSTEIN, David M, WEINBERG, Robert A, CONDEELIS, John S

“…Epithelial-mesenchymal transition (EMT) is a developmental program implicated in cancer progression and was the subject of the 2010 AACR meeting on the topic…”
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Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition by Buck, Elizabeth, Eyzaguirre, Alexandra, Barr, Sharon, Thompson, Stuart, Sennello, Regina, Young, David, Iwata, Kenneth K, Gibson, Neil W, Cagnoni, Pablo, Haley, John D

“…Overexpression and enhanced activation of the epidermal growth factor receptor (EGFR) is frequently observed in human carcinomas. Inhibitors of EGFR signaling…”
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Development of a 5-FU modified miR-129 mimic as a therapeutic for non-small cell lung cancer by Hwang, Ga-Ram, Yuen, John G., Fesler, Andrew, Farley, Hannah, Haley, John D., Ju, Jingfang

“…Lung cancer is the leading cause of cancer-related deaths in the United States with non-small cell lung cancer (NSCLC) accounting for most cases. Despite…”
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Mass Spectrometry and Pharmacological Approaches to Measuring Cooption and Reciprocal Activation of Receptor Tyrosine Kinases by Linzer, Jason, Phelps, Zachary, Vummidi, Shivasuryan, Lee, Bo Young Elizabeth, Coant, Nicolas, Haley, John D

“…Receptor tyrosine kinases (RTKs) can show extensive crosstalk, directly and indirectly. Elucidating RTK crosstalk remains an important goal in the clinical…”
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Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity by Buck, Elizabeth, Eyzaguirre, Alexandra, Haley, John D, Gibson, Neil W, Cagnoni, Pablo, Iwata, Kenneth K

“…Signaling through the receptor for epidermal growth factor receptor (EGFR) is frequently deregulated in solid tumors. Erlotinib (Tarceva, OSI-774, OSI…”
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Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer by Montal, Emily D, Bhalla, Kavita, Dewi, Ruby E, Ruiz, Christian F, Haley, John A, Ropell, Ashley E, Gordon, Chris, Haley, John D, Girnun, Geoffrey D

“…Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a…”
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Phosphotyrosine Signaling Networks in Epidermal Growth Factor Receptor Overexpressing Squamous Carcinoma Cells by Thelemann, April, Petti, Filippo, Griffin, Graeme, Iwata, Ken, Hunt, Tony, Settinari, Tina, Fenyo, David, Gibson, Neil, Haley, John D

“…Overexpression and enhanced activation of the epidermal growth factor (EGF) receptor are frequent events in human cancers that correlate with poor prognosis…”
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