Search Results - "HALENE, Tobias"

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders by Yu, Qianhui, He, Zhisong, Zubkov, Dmitry, Huang, Shuyun, Kurochkin, Ilia, Yang, Xiaode, Halene, Tobias, Willmitzer, Lothar, Giavalisco, Patrick, Akbarian, Schahram, Khaitovich, Philipp

“…Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in…”
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Critical Role of Histone Turnover in Neuronal Transcription and Plasticity by Maze, Ian, Wenderski, Wendy, Noh, Kyung-Min, Bagot, Rosemary C., Tzavaras, Nikos, Purushothaman, Immanuel, Elsässer, Simon J., Guo, Yin, Ionete, Carolina, Hurd, Yasmin L., Tamminga, Carol A., Halene, Tobias, Farrelly, Lorna, Soshnev, Alexey A., Wen, Duancheng, Rafii, Shahin, Birtwistle, Marc R., Akbarian, Schahram, Buchholz, Bruce A., Blitzer, Robert D., Nestler, Eric J., Yuan, Zuo-Fei, Garcia, Benjamin A., Shen, Li, Molina, Henrik, Allis, C. David

“…Turnover and exchange of nucleosomal histones and their variants, a process long believed to be static in post-replicative cells, remains largely unexplored in…”
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Understanding the genetic liability to schizophrenia through the neuroepigenome by Fullard, John F, Halene, Tobias B, Giambartolomei, Claudia, Haroutunian, Vahram, Akbarian, Schahram, Roussos, Panos

“…Abstract The Psychiatric Genomics Consortium-Schizophrenia Workgroup (PGC-SCZ) recently identified 108 loci associated with increased risk for schizophrenia…”
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Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia by Carlson, Gregory C, Talbot, Konrad, Halene, Tobias B, Gandal, Michael J, Kazi, Hala A, Schlosser, Laura, Phung, Quan H, Gur, Raquel E, Arnold, Steven E, Siegel, Steven J

“…DTNBP1 (dystrobrevin binding protein 1) is a leading candidate susceptibility gene in schizophrenia and is associated with working memory capacity in normal…”
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Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism by Liu, Xiling, Han, Dingding, Somel, Mehmet, Jiang, Xi, Hu, Haiyang, Guijarro, Patricia, Zhang, Ning, Mitchell, Amanda, Halene, Tobias, Ely, John J, Sherwood, Chet C, Hof, Patrick R, Qiu, Zilong, Pääbo, Svante, Akbarian, Schahram, Khaitovich, Philipp

“…Cognitive defects in autism spectrum disorder (ASD) include socialization and communication: key behavioral capacities that separate humans from other species…”
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Metabolome signature of autism in the human prefrontal cortex by Kurochkin, Ilia, Khrameeva, Ekaterina, Tkachev, Anna, Stepanova, Vita, Vanyushkina, Anna, Stekolshchikova, Elena, Li, Qian, Zubkov, Dmitry, Shichkova, Polina, Halene, Tobias, Willmitzer, Lothar, Giavalisco, Patrick, Akbarian, Schahram, Khaitovich, Philipp

“…Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of…”
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Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors by Hasan, Alkomiet, Mitchell, Amanda, Schneider, Anja, Halene, Tobias, Akbarian, Schahram

“…Notwithstanding the considerable advances in the treatment options for schizophrenia, the cognitive symptoms in particular are not receptive to antipsychotic…”
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Mouse behavioral endophenotypes for schizophrenia by Amann, Laura C, Gandal, Michael J, Halene, Tobias B, Ehrlichman, Richard S, White, Samantha L, McCarren, Hilary S, Siegel, Steven J

“…Abstract An endophenotype is a heritable trait that is generally considered to be more highly, associated with a gene-based neurological deficit than a disease…”
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PDE inhibitors in psychiatry – future options for dementia, depression and schizophrenia? by Halene, Tobias B., Siegel, Steven J.

“…Phosphodiesterases are key enzymes in cellular signalling pathways. They degrade cyclic nucleotides and their inhibition via specific inhibitors offers unique…”
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Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials by Featherstone, Robert E, Phillips, Jennifer M, Thieu, Tony, Ehrlichman, Richard S, Halene, Tobias B, Leiser, Steven C, Christian, Edward, Johnson, Edwin, Lerman, Caryn, Siegel, Steven J

“…Individuals with schizophrenia show increased smoking rates which may be due to a beneficial effect of nicotine on cognition and information processing…”
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A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons by Espeso-Gil, Sergio, Halene, Tobias, Bendl, Jaroslav, Kassim, Bibi, Ben Hutta, Gabriella, Iskhakova, Marina, Shokrian, Neda, Auluck, Pavan, Javidfar, Behnam, Rajarajan, Prashanth, Chandrasekaran, Sandhya, Peter, Cyril J, Cote, Alanna, Birnbaum, Rebecca, Liao, Will, Borrman, Tyler, Wiseman, Jennifer, Bell, Aaron, Bannon, Michael J, Roussos, Panagiotis, Crary, John F, Weng, Zhiping, Marenco, Stefano, Lipska, Barbara, Tsankova, Nadejda M, Huckins, Laura, Jiang, Yan, Akbarian, Schahram

“…Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain's neuronal population and mediate cognition, food intake, and metabolism. MDN are also…”
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Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia by Gusev, Fedor E., Reshetov, Denis A., Mitchell, Amanda C., Andreeva, Tatiana V., Dincer, Aslihan, Grigorenko, Anastasia P., Fedonin, Gennady, Halene, Tobias, Aliseychik, Maria, Filippova, Elena, Weng, Zhiping, Akbarian, Schahram, Rogaev, Evgeny I.

“…Both heritability and environment contribute to risk for schizophrenia. However, the molecular mechanisms of interactions between genetic and non-genetic…”
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Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms by Schmitt, Andrea, Martins-de-Souza, Daniel, Akbarian, Schahram, Cassoli, Juliana S., Ehrenreich, Hannelore, Fischer, Andre, Fonteh, Alfred, Gattaz, Wagner F., Gawlik, Michael, Gerlach, Manfred, Grünblatt, Edna, Halene, Tobias, Hasan, Alkomiet, Hashimoto, Kenij, Kim, Yong-Ku, Kirchner, Sophie-Kathrin, Kornhuber, Johannes, Kraus, Theo F.J., Malchow, Berend, Nascimento, Juliana M., Rossner, Moritz, Schwarz, Markus, Steiner, Johann, Talib, Leda, Thibaut, Florence, Riederer, Peter, Falkai, Peter

“…Objectives: Despite progress in identifying molecular pathophysiological processes in schizophrenia, valid biomarkers are lacking for both the disease and…”
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NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure by Halene, Tobias B, Kozlenkov, Alexey, Jiang, Yan, Mitchell, Amanda C, Javidfar, Behnam, Dincer, Aslihan, Park, Royce, Wiseman, Jennifer, Croxson, Paula L, Giannaris, Eustathia Lela, Hof, Patrick R, Roussos, Panos, Dracheva, Stella, Hemby, Scott E, Akbarian, Schahram

“…Abstract Increased neuronal densities in subcortical white matter have been reported for some cases with schizophrenia. The underlying cellular and molecular…”
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Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials by Amann, Laura C, Halene, Tobias B, Ehrlichman, Richard S, Luminais, Stephen N, Ma, Nan, Abel, Ted, Siegel, Steven J

“…Abstract Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever…”
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Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice by Bodarky, Christina L, Halene, Tobias B, Ehrlichman, Richard S, Banerjee, Anamika, Ray, Rabindranath, Hahn, Chang-Gyu, Jonak, Gerald, Siegel, Steven J

“…Clinical and experimental data suggest dysregulation of N-methyl-d-aspartate receptor (NMDAR)-mediated glutamatergic pathways in schizophrenia. The interaction…”
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Epigenetic Dysregulation in the Schizophrenic Brain by Halene, Tobias B., Peter, Cyril J., Akbarian, Schahram

“…Schizophrenia (SCZ) is a severe psychiatric disorder, which lacks a unifying neuropathology. However, reproducible molecular alterations exist, including RNA…”
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Predator odor modulates auditory event-related potentials in mice by Halene, Tobias B, Talmud, Jon, Jonak, Gerald J, Schneider, Frank, Siegel, Steven J

“…Animals process information from different sensory modalities, requiring integration of signals and assignment of significance. People with schizophrenia…”
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Male and Female Mice Differ for Baseline and Nicotine-Induced Event Related Potentials by Amann, Laura C, Phillips, Jennifer M, Halene, Tobias B, Siegel, Steven J

“…The usage patterns and biological effects of cigarette smoking differ significantly among men and women. This study seeks to clarify the interaction that…”
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Remifentanil directly activates human N-methyl-D-aspartate receptors expressed in xenopus laevis oocytes by HAHNENKAMP, Klaus, NOLLET, Joke, HOENEMANN, Christian W, VAN AKEN, Hugo K, BUERKLE, Hartmut, HALENE, Tobias, SCHAUERTE, Svenja, HAHNENKAMP, Anke, HOLLMANN, Markus W, STRÜMPER, Danja, DURIEUX, Marcel E

“…Clinical studies suggest that intraoperative administration of the clinical remifentanil formulation Ultiva (GlaxoWellcome GmbH & Co, Bad Oldesloe, Germany)…”
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