Search Results - "HALAYKO, Andrew J"

Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry by Hambly, Nathan, Farooqi, M Malik, Dvorkin-Gheva, Anna, Donohoe, Kathryn, Garlick, Kristopher, Scallan, Ciaran, Chong, Sy Giin, MacIsaac, Sarah, Assayag, Deborah, Johannson, Kerri A, Fell, Charlene D, Marcoux, Veronica, Manganas, Helene, Morisset, Julie, Comes, Alessia, Fisher, Jolene H, Shapera, Shane, Gershon, Andrea S, To, Teresa, Wong, Alyson W, Sadatsafavi, Mohsen, Wilcox, Pierce G, Halayko, Andrew J, Khalil, Nasreen, Cox, Gerard, Richeldi, Luca, Ryerson, Christopher J, Kolb, Martin

“…Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by progressive physiological, symptomatic and/or radiographic worsening. The…”
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Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells by Prefontaine, David, Lajoie-Kadoch, Stephane, Foley, Susan, Audusseau, Severine, Olivenstein, Ron, Halayko, Andrew J, Lemiere, Catherine, Martin, James G, Hamid, Qutayba

“…IL-33, a new member of the IL-1 cytokine family, promotes Th2 inflammation, but evidence on the implications of this cytokine in asthma is lacking. IL-33 would…”
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MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle by Comer, Brian S, Camoretti-Mercado, Blanca, Kogut, Paul C, Halayko, Andrew J, Solway, Julian, Gerthoffer, William T

“…MicroRNA (miR)-146a and miR-146b are negative regulators of inflammatory gene expression in lung fibroblasts, epithelial cells, monocytes, and endothelial…”
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An Official American Thoracic Society Research Statement: Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling by Prakash, Y S, Halayko, Andrew J, Gosens, Reinoud, Panettieri, Jr, Reynold A, Camoretti-Mercado, Blanca, Penn, Raymond B

“…Airway remodeling (AR) is a prominent feature of asthma and other obstructive lung diseases that is minimally affected by current treatments. The goals of this…”
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Muscarinic receptor signaling in the pathophysiology of asthma and COPD by Gosens, Reinoud, Zaagsma, Johan, Meurs, Herman, Halayko, Andrew J

“…Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for asthma. Primarily used as bronchodilators, they reverse the action of…”
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Characterization of sex-related differences in allergen house dust mite-challenged airway inflammation, in two different strains of mice by Mostafa, Dina H. D., Hemshekhar, Mahadevappa, Piyadasa, Hadeesha, Altieri, Anthony, Halayko, Andrew J., Pascoe, Christopher D., Mookherjee, Neeloffer

“…Biological sex impacts disease prevalence, severity and response to therapy in asthma, however preclinical studies often use only one sex in murine models…”
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Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma by Movassagh, Hesam, Shan, Lianyu, Mohammed, Ashfaque, Halayko, Andrew J, Gounni, Abdelilah S

“…Semaphorin 3E (Sema3E) plays a crucial role in axon guidance, vascular patterning, and immune regulation. Nevertheless, the role of Sema3E in asthma is still…”
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Neuronal chemorepellent Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration by Movassagh, Hesam, MSc, Shan, Lianyu, MSc, Halayko, Andrew J., PhD, Roth, Michael, PhD, Tamm, Michael, MD, Chakir, Jamila, PhD, Gounni, Abdelilah S., PhD

“…Background Chronic airway diseases, including asthma, are characterized by increased airway smooth muscle (ASM) mass that is due in part to growth…”
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Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1 by Yeganeh, Behzad, Ghavami, Saeid, Kroeker, Andrea L, Mahood, Thomas H, Stelmack, Gerald L, Klonisch, Thomas, Coombs, Kevin M, Halayko, Andrew J

“…Subcellular trafficking within host cells plays a critical role in viral life cycles, including influenza A virus (IAV). Thus targeting relevant subcellular…”
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S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3 by Ghavami, Saeid, Eshragi, Mehdi, Ande, Sudharsana R, Chazin, Walter J, Klonisch, Thomas, Halayko, Andrew J, Mcneill, Karol D, Hashemi, Mohammad, Kerkhoff, Claus, Los, Marek

“…The complex formed by two members of the S100 calcium-binding protein family, S100A8/A9, exerts apoptosisinducing activity in various cells of different…”
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Novel DNA methylation changes in mouse lungs associated with chronic smoking by Onuzulu, Chinonye Doris, Lee, Samantha, Basu, Sujata, Comte, Jeannette, Hai, Yan, Hizon, Nikho, Chadha, Shivam, Fauni, Maria Shenna, Halayko, Andrew J, Pascoe, Christopher D, Jones, Meaghan J

“…Smoking is a potent cause of asthma exacerbations, chronic obstructive pulmonary disease (COPD) and many other health defects, and changes in DNA methylation…”
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Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis by Sharma, Pawan, Alizadeh, Javad, Juarez, Maya, Samali, Afshin, Halayko, Andrew J, Kenyon, Nicholas J, Ghavami, Saeid, Zeki, Amir A

“…Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological processes essential for manifold cellular functions in health and…”
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Th17‐associated cytokines promote human airway smooth muscle cell proliferation by Chang, Ying, Al‐Alwan, Laila, Risse, Paul‐André, Halayko, Andrew J., Martin, James G., Baglole, Carolyn J., Eidelman, David H., Hamid, Qutayba

“…Increased airway smooth muscle (ASM) mass is a hallmark of airway remodeling in severe asthma. Th17‐associated cytokines, particularly IL‐17A, IL‐17F, and…”
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High-mobility group box 1 promotes extracellular matrix synthesis and wound repair in human bronchial epithelial cells by Ojo, Oluwaseun O, Ryu, Min Hyung, Jha, Aruni, Unruh, Helmut, Halayko, Andrew J

“…High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) protein that binds Toll-like receptors (e.g., TLR4) and the receptor for…”
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Glucocorticoids regulate pentraxin-3 expression in human airway smooth muscle cells by Zhang, Jingbo, Koussih, Latifa, Shan, Lianyu, Halayko, Andrew J, Tliba, Omar, Gounni, Abdelilah S

“…Pentraxin-3 (PTX3) is a multifunctional protein involved in both innate and adaptive immunity. Glucocorticoid (GC) is the first-line therapy to mitigate airway…”
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Expression of Semaphorin 3E Is Suppressed in Severe Asthma by Movassagh, Hesam, PhD, Shan, Lianyu, MSc, Chakir, Jamila, PhD, McConville, John F., MD, Halayko, Andrew J., PhD, Koussih, Latifa, PhD, Gounni, Abdelilah S., PhD

“…Summary The level of a previously unknown mediator, Semaphorin 3E, is diminished in the airways of severe allergic asthmatic patients. This study suggests a…”
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Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways by Shan, Lianyu, Redhu, Naresh Singh, Saleh, Ali, Halayko, Andrew J, Chakir, Jamila, Gounni, Abdelilah S

“…Thymic stromal lymphopoietin (TSLP) plays a pivotal role in allergic diseases such as asthma, chronic obstructive pulmonary disease, and atopic dermatitis…”
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Temporal and Spatial Patterns of Inflammation and Tissue Injury in Patients with Postoperative Respiratory Failure after Lung Resection Surgery: A Nested Case-Control Study by Kormish, Jay, Ghuman, Tejas, Liu, Richard Y, Srinathan, Sadeesh K, Tan, Lawrence, Graham, Kristen, Enns, Stephanie, Buduhan, Gordon, Halayko, Andrew J, Pascoe, Christopher D, Kidane, Biniam

“…Thoracic surgeries involving resection of lung tissue pose a risk of severe postoperative pulmonary complications, including acute respiratory distress…”
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Airway mesenchymal cell death by mevalonate cascade inhibition: Integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins by Ghavami, Saeid, Sharma, Pawan, Yeganeh, Behzad, Ojo, Oluwaseun O., Jha, Aruni, Mutawe, Mark M., Kashani, Hessam H., Los, Marek J., Klonisch, Thomas, Unruh, Helmut, Halayko, Andrew J.

“…HMG-CoA reductase, the proximal rate-limiting enzyme in the mevalonate pathway, is inhibited by statins. Beyond their cholesterol lowering impact, statins have…”
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Semaphorin 3E Alleviates Hallmarks of House Dust Mite–Induced Allergic Airway Disease by Movassagh, Hesam, Shan, Lianyu, Duke-Cohan, Jonathan S, Halayko, Andrew J, Uzonna, Jude E, Gounni, Abdelilah S

“…Semaphorins are an essential family of guidance cues ubiquitously expressed in various organs, which play diverse developmental, homeostatic, and pathological…”
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