Search Results - "HAJJAR, K. A"

Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor by HAJJAR, K. A

“…Endothelial cells impart thromboresistance to the blood vessel wall. As modulators of fibrinolytic activity, these cells synthesize and secrete tissue…”
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An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II by HAJJAR, K. A, JACOVINA, A. T, CHACKO, J

“…Sequencing of two internal peptides from the putative human endothelial cell tissue plasminogen activator (t-PA) receptor identified an analog of the calcium-…”
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Annexin II and Bleeding in Acute Promyelocytic Leukemia by Menell, Jill S, Cesarman, Gabriela M, Jacovina, Andrew T, McLaughlin, Mary Ann, Lev, Emil A, Hajjar, Katherine A

“…In acute promyelocytic leukemia (APL) there is clonal expansion of immature promyelocytes with a characteristic balanced translocation,…”
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An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation by CESARMAN, G. M, GUEVARA, C. A, HAJJAR, K. A

“…In the preceding paper (Hajjar, K. A., Jacovina, A. T., and Chacko, J. (1994) J. Biol. Chem. 269, 21191-21197), we identified a M(r) = 40,000 endothelial cell…”
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Homocysteine: a sulph'rous fire by Hajjar, K A

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The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39 by Marcus, A J, Broekman, M J, Drosopoulos, J H, Islam, N, Alyonycheva, T N, Safier, L B, Hajjar, K A, Posnett, D N, Schoenborn, M A, Schooley, K A, Gayle, R B, Maliszewski, C R

“…We previously demonstrated that when platelets are in motion and in proximity to endothelial cells, they become unresponsive to agonists (Marcus, A.J., L.B…”
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Cellular receptors in the regulation of plasmin generation by Hajjar, K A

“…Cell surface receptors may play a significant role in the regulation of plasmin generation. Although structurally diverse, these receptors can be classified on…”
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Thrombotic thrombocytopenic purpura and sporadic hemolytic-uremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells by MITRA, D, JAFFE, E. A, WEKSLER, B, HAJJAR, K. A, SODERLAND, C, LAURENCE, J

“…Thrombotic thrombocytopenic purpura (TTP) and sporadic hemolytic-uremic syndrome (HUS) are thrombotic microangiopathies that occur in the absence of an…”
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Lipoprotein (a) regulates plasminogen activator inhibitor-1 expression in endothelial cells. A potential mechanism in thrombogenesis by ETINGIN, O. R, HAJJAR, D. P, HAJJAR, K. A, HARPEL, P. C, NACHMAN, R. L

“…Lipoprotein (a) (Lp(a)) is a low density lipoprotein-like particle which contains the plasminogen-like apolipoprotein a. Lp(a) levels are elevated in patients…”
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Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine by Hajjar, K A, Mauri, L, Jacovina, A T, Zhong, F, Mirza, U A, Padovan, J C, Chait, B T

“…Tissue plasminogen activator binds to endothelial cells via the calcium-regulated phospholipid-binding protein annexin II, an interaction that is inhibited by…”
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The endothelial cell tissue plasminogen activator receptor. Specific interaction with plasminogen by HAJJAR, K. A

“…Human endothelial cells (EC) assemble plasmin-generating proteins on their surface. We have previously identified an EC membrane protein (Mr approximately…”
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Recombinant angiostatin prevents retinal neovascularization in a murine proliferative retinopathy model by MENESES, P. I, HAJJAR, K. A, BERNS, K. I, DUVOISIN, R. M

“…Retinal neovascularization is central to the pathogenesis of proliferative diabetic retinopathy, the leading cause of blindness among the middle-aged…”
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Lipoprotein( a ) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis by Hajjar, Katherine A, Gavishi, Dov, Breslow, Jan L, Nachman, Ralph L

“…Endothelial cells play a critical role in thromboregulation by virtue of a surface-connected fibrinolytic system. Cultured endothelial cells synthesize and…”
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Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activator and urokinase by HAJJAR, K. A, HAMEL, N. M

“…Cultured human endothelial cells synthesize and secrete two types of plasminogen activator, tissue plasminogen activator (t-PA) and urokinase (u-PA). Previous…”
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Inhibition of endothelial cell thromboresistance by homocysteine by Ling, Q, Hajjar, K A

“…Homocysteine (HC) is a highly reactive thiol intermediate in amino acid metabolism, which can modify the function of endothelial cells in a myriad of ways. In…”
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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth by Benezra, Robert, Rafii, Shahin, Lyden, David, Hattori, Koichi, Dias, Sergio, Costa, Carla, Blaikie, Pamela, Butros, Linda, Chadburn, Amy, Heissig, Beate, Marks, Willy, Witte, Larry, Wu, Yan, Hicklin, Daniel, Zhu, Zhenping, Hackett, Neil R, Crystal, Ronald G, Moore, Malcolm A.S, Hajjar, Katherine A, Manova, Katia

“…The role of bone marrow (BM)-derived precursor cells in tumor angiogenesis is not known. We demonstrate here that tumor angiogenesis is associated with…”
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Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions by Marcus, A J, Safier, L B, Broekman, M J, Islam, N, Fliessbach, J H, Hajjar, K A, Kaminski, W E, Jendraschak, E, Silverstein, R L, von Schacky, C

“…Platelet activation as a result of vascular injury provokes endothelial cells to respond in a manner which limits or reverses the occlusive consequences of…”
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Binding of tissue plasminogen activator to cultured human endothelial cells by HAJJAR, K. A, HAMEL, N. M, HARPEL, P. C, NACHMAN, R. L

“…Tissue plasminogen activator (t-PA) and urokinase (u-PA), the major activators of plasminogen, are synthesized and released from endothelial cells. We…”
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THE ROLE OF LIPOPROTEIN(a) IN ATHEROGENESIS AND THROMBOSIS by Hajjar, M.D, Katherine A, Nachman, M.D, Ralph L

“…Lipoprotein(a) [Lp(a)] represents an important independent risk factor for atherosclerotic cardiovascular disease. Lp(a) constitutes a class of low-density…”
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Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor by NACHMAN, R. L, HAJJAR, K. A, SILVERSTEIN, R. L, DINARELLO, C. A

“…Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor…”
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