Search Results - "HAIYONG HAN"

RNA Interference to Knock Down Gene Expression by Han, Haiyong

“…RNA interference (RNAi) is a biological process by which double-stranded RNA (dsRNA) induces sequence-specific gene silencing by targeting mRNA for…”
Get more information

Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression by Yoshida, Kazuhiro, Toden, Shusuke, Ravindranathan, Preethi, Han, Haiyong, Goel, Ajay

“…Development of resistance to chemotherapeutic drugs is a major challenge in the care of patients with pancreatic ductal adenocarcinoma (PDAC). Acquired…”
Get full text

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer by Whatcott, Clifford J, Diep, Caroline H, Jiang, Ping, Watanabe, Aprill, LoBello, Janine, Sima, Chao, Hostetter, Galen, Shepard, H Michael, Von Hoff, Daniel D, Han, Haiyong

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by high levels of fibrosis, termed desmoplasia, which is thought to hamper the efficacy of…”
Get full text

Perineural invasion and associated pain in pancreatic cancer by Han, Haiyong, Bapat, Aditi A, Hostetter, Galen, Von Hoff, Daniel D

“…Key Points Perineural invasion (PNI) is the process through which cancer cells invade the perineural spaces of surrounding nerves and is not simply the…”
Get full text

Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions by Lin, Wei, Noel, Pawan, Borazanci, Erkut H, Lee, Jeeyun, Amini, Albert, Han, In Woong, Heo, Jin Seok, Jameson, Gayle S, Fraser, Cory, Steinbach, Margaux, Woo, Yanghee, Fong, Yuman, Cridebring, Derek, Von Hoff, Daniel D, Park, Joon Oh, Han, Haiyong

“…Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor cells constantly…”
Get full text

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism by Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.

“…Our recent ERK1/2 inhibitor analyses in pancreatic ductal adenocarcinoma (PDAC) indicated ERK1/2-independent mechanisms maintaining MYC protein stability. To…”
Get full text

Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors by Al-Hader, Ahmad, Al-Rohil, Rami N, Han, Haiyong, Hoff, Daniel Von

“…Pancreatic carcinomas with acinar differentiation are rare,accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell…”
Get full text

Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer by Whatcott, Clifford J, Ng, Serina, Barrett, Michael T, Hostetter, Galen, Von Hoff, Daniel D, Han, Haiyong

“…ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC kinase family and has been shown to play a role in cell migration, ECM…”
Get full text

Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells by Bapat, Aditi A, Munoz, Ruben M, Von Hoff, Daniel D, Han, Haiyong

“…Perineural invasion (PNI) is thought to be one of the factors responsible for the high rate of tumor recurrence after surgery and the pain generation…”
Get full text

Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer by Li, Yuan, Xu, Caiming, Han, Haiyong, Pascual-Sabater, Silvia, Fillat, Cristina, Goel, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor survival rates, primarily due to the limited effectiveness of gemcitabine…”
Get full text

Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies by Shen, Jiayin, Hu, Yingwen, Putt, Karson S, Singhal, Sunil, Han, Haiyong, Visscher, Daniel W, Murphy, Linda M, Low, Philip S

“…A number of folate receptor (FR) targeted small molecular drugs and monoclonal antibodies have been introduced into clinical trials to treat FR positive…”
Get full text

Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma by Okuno, Keisuke, Xu, Caiming, Pascual-Sabater, Silvia, Tokunaga, Masanori, Han, Haiyong, Fillat, Cristina, Kinugasa, Yusuke, Goel, Ajay

“…Gemcitabine (Gem)-based chemotherapy is one of the first-line treatments for pancreatic ductal adenocarcinoma (PDAC). However, its clinical effect is limited…”
Get full text

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR) by Botrus, Gehan, Miller, Richard M, Uson Junior, Pedro Luiz Serrano, Kannan, Geoffrey, Han, Haiyong, Von Hoff, Daniel D

“…High rates of cell proliferation and protein synthesis in pancreatic cancer are among many factors leading to endoplasmic reticulum (ER) stress. To restore…”
Get full text

Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression by Li, Xiaoming, Shepard, H Michael, Cowell, Jessica A, Zhao, Chunmei, Osgood, Ryan J, Rosengren, Sanna, Blouw, Barbara, Garrovillo, Sheryl A, Pagel, Mark D, Whatcott, Clifford J, Han, Haiyong, Von Hoff, Daniel D, Taverna, Darin M, LaBarre, Michael J, Maneval, Daniel C, Thompson, Curtis B

“…The tumor microenvironment (TME) evolves to support tumor progression. One marker of more aggressive malignancy is hyaluronan (HA) accumulation. Here, we…”
Get full text

Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look by Whatcott, Clifford J, Han, Haiyong, Posner, Richard G, Hostetter, Galen, Von Hoff, Daniel D

“…Increased extracellular matrix (ECM) deposition is a characteristic observed in many solid tumors. Increased levels of one ECM component-namely, hyaluronan…”
Get more information

Advanced glycation end product (AGE) targeting antibody SIWA318H is efficacious in preclinical models for pancreatic cancer by Rossi, Gabriela R., Jensen, Ashley, Ng, Serina, Yin, Zhirong, Li, Aimin, Misra, Anjan, Von Hoff, Daniel D., Gruber, Lewis, Gruber, Misty, Han, Haiyong

“…SIWA318H is a novel monoclonal antibody that selectively targets an advanced glycation end product biomarker found in damaged/dysfunctional cells exhibiting…”
Get full text

Ultra-Sensitive Automated Profiling of EpCAM Expression on Tumor-Derived Extracellular Vesicles by Amrollahi, Pouya, Rodrigues, Meryl, Lyon, Christopher J, Goel, Ajay, Han, Haiyong, Hu, Tony Y

“…Extracellular vesicles (EVs) are abundant in most biological fluids and considered promising biomarker candidates, but the development of EV biomarker assays…”
Get full text

Synergistic Effect between Erlotinib and MEK Inhibitors in KRAS Wild-Type Human Pancreatic Cancer Cells by DIEP, Caroline H, MUNOZ, Ruben M, CHOUDHARY, Ashish, VON HOFF, Daniel D, HAIYONG HAN

“…The combination of erlotinib and gemcitabine has shown a small but statistically significant survival advantage when compared with gemcitabine alone in…”
Get full text

Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist by Wnorowski, Artur, Dudzik, Danuta, Bernier, Michel, Wójcik, Jakub, Keijzers, Guido, Diaz-Ruiz, Alberto, Mazur, Karolina, Zhang, Yongqing, Han, Haiyong, Scheibye-Knudsen, Morten, Jozwiak, Krzysztof, Barbas, Coral, Wainer, Irving W.

“…Metabolic reprogramming contributes to oncogenesis, tumor growth, and treatment resistance in pancreatic ductal adenocarcinoma (PDAC). Here we report the…”
Get full text

Tumor and Peritoneum-Associated Macrophage Gene Signature as a Novel Molecular Biomarker in Gastric Cancer by Sullivan, Kevin M, Li, Haiqing, Yang, Annie, Zhang, Zhifang, Munoz, Ruben R, Mahuron, Kelly M, Yuan, Yate-Ching, Paz, Isaac Benjamin, Von Hoff, Daniel, Han, Haiyong, Fong, Yuman, Woo, Yanghee

“…A spectrum of immune states resulting from tumor resident macrophages and T-lymphocytes in the solid tumor microenvironment correlates with patient outcomes…”
Get full text