Search Results - "HAILES, Helen C"

Reaction Solvent Selection:  The Potential of Water as a Solvent for Organic Transformations by Hailes, Helen C

“…The increasing need for more sustainable strategies in organic synthesis has led to a growing interest in the use of water and other nonclassical solvents…”
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Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines by Lichman, Benjamin R., Zhao, Jianxiong, Hailes, Helen C., Ward, John M.

“…The Pictet–Spengler reaction (PSR) involves the condensation and ring closure between a β-arylethylamine and a carbonyl compound. The combination of dopamine…”
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Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines by Erdmann, Vanessa, Lichman, Benjamin R., Zhao, Jianxiong, Simon, Robert C., Kroutil, Wolfgang, Ward, John M., Hailes, Helen C., Rother, Dörte

“…Chemoenzymatic and enzymatic cascade reactions enable the synthesis of complex stereocomplementary 1,3,4‐trisubstituted tetrahydroisoquinolines (THIQs) with…”
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Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials by Sehl, Torsten, Hailes, Helen C., Ward, John M., Wardenga, Rainer, von Lieres, Eric, Offermann, Heike, Westphal, Robert, Pohl, Martina, Rother, Dörte

“…Two steps in one pot: An enzyme cascade consisting of a lyase and an (R)‐ or (S)‐selective ω‐transaminase (TA) provides (1R,2R)‐norpseudoephedrine and…”
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The performance and environmental impact of pro-oxidant additive containing plastics in the open unmanaged environment-a review of the evidence by Sciscione, Fabiola, Hailes, Helen C, Miodownik, Mark

“…Pro-oxidant additive containing (PAC) plastics is a term that describes a growing number of plastics which are designed to degrade in the unmanaged natural…”
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Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants by Wang, Yu, Subrizi, Fabiana, Carter, Eve M., Sheppard, Tom D., Ward, John M., Hailes, Helen C.

“…Benzylisoquinoline alkaloid derived pharmaceuticals are widely applied in modern medicines. Recent studies on the microbial production of benzylisoquinolines…”
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pET expression vector customized for efficient seamless cloning by Dobrijevic, Dragana, Nematollahi, Lily A, Hailes, Helen C, Ward, John M

“…Here we present a modification of the widely used pET29 expression vector for use in rapid and straightforward parallel cloning via a gene replacement and…”
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Liquid-microjet photoelectron spectroscopy of the green fluorescent protein chromophore by Tau, Omri, Henley, Alice, Boichenko, Anton N., Kleshchina, Nadezhda N., Riley, River, Wang, Bingxing, Winning, Danielle, Lewin, Ross, Parkin, Ivan P., Ward, John M., Hailes, Helen C., Bochenkova, Anastasia V., Fielding, Helen H.

“…Green fluorescent protein (GFP), the most widely used fluorescent protein for in vivo monitoring of biological processes, is known to undergo photooxidation…”
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One-pot, two-step transaminase and transketolase synthesis of l-gluco-heptulose from l-arabinose by Bawn, Maria, Subrizi, Fabiana, Lye, Gary J., Sheppard, Tom D., Hailes, Helen C., Ward, John M.

“…•Characterisation of new thermostable transketolase and transaminase enzymes towards L-arabinose and L-serine.•Explored novel thermostable transaminases to…”
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Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids by Pesnot, Thomas, Gershater, Markus C, Ward, John M, Hailes, Helen C

“…A one-pot synthesis of tetrahydroisoquinoline alkaloids in a phosphate buffer has been achieved, and a reaction mechanism proposed. The utilisation of mild…”
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The substrate specificity, enantioselectivity and structure of the (R)‐selective amine : pyruvate transaminase from Nectria haematococca by Sayer, Christopher, Martinez‐Torres, Ruben J., Richter, Nina, Isupov, Michail N., Hailes, Helen C., Littlechild, Jennifer A., Ward, John M.

“…During the last decade the use of transaminases for the production of pharmaceutical and fine chemical intermediates has attracted a great deal of attention…”
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Mechanism of resonant electron emission from the deprotonated GFP chromophore and its biomimetics by Bochenkova, Anastasia V, Mooney, Ciarán R S, Parkes, Michael A, Woodhouse, Joanne L, Zhang, Lijuan, Lewin, Ross, Ward, John M, Hailes, Helen C, Andersen, Lars H, Fielding, Helen H

“…The Green Fluorescent Protein (GFP), which is widely used in bioimaging, is known to undergo light-induced redox transformations. Electron transfer is thought…”
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Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the Brain by Kenny, Gavin D, Bienemann, Alison S, Tagalakis, Aristides D, Pugh, John A, Welser, Katharina, Campbell, Frederick, Tabor, Alethea B, Hailes, Helen C, Gill, Steven S, Lythgoe, Mark F, McLeod, Cameron W, White, Edward A, Hart, Stephen L

“…Abstract Convection enhanced delivery (CED) is a method of direct injection to the brain that can achieve widespread dispersal of therapeutics, including gene…”
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The use of tyrosinases in a chemoenzymatic cascade as a peptide ligation strategy by Ni, Yeke, Wang, Yu, Tabor, Alethea B, Ward, John M, Hailes, Helen C

“…Peptides play many key roles in biological systems and numerous methods have been developed to generate both natural and unnatural peptides. However,…”
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Development of a microwave-assisted sustainable conversion of furfural hydrazones to functionalised phthalimides in ionic liquids by Karaluka, Valerija, Murata, Kengo, Masuda, Shinto, Shiramatsu, Yuto, Kawamoto, Takuji, Hailes, Helen C, Sheppard, Tom D, Kamimura, Akio

“…A sustainable synthetic procedure to convert furfural hydrazones into functionalised phthalimides was developed. The reaction was performed in a microwave…”
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Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations by Foster, Robert W., Tame, Christopher J., Hailes, Helen C., Sheppard, Tom D.

“…(Cyclooctadiene)(pentamethylcyclopentadiene)ruthenium chloride [Cp*RuCl(cod)] has been used to catalyze the regioselective cyclization of amide‐tethered diynes…”
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Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis by Roddan, Rebecca, Ward, John M., Keep, Nicholas H., Hailes, Helen C.

“…Pictet–Spenglerases provide a key role in the biosynthesis of many biologically active alkaloids. There is increasing use of these biocatalysts as an…”
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Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium by Manunta, Maria D I, McAnulty, Robin J, Tagalakis, Aristides D, Bottoms, Stephen E, Campbell, Frederick, Hailes, Helen C, Tabor, Alethea B, Laurent, Geoffrey J, O'Callaghan, Christopher, Hart, Stephen L

“…Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must…”
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Gene Delivery Using Ternary Lipopolyplexes Incorporating Branched Cationic Peptides: The Role of Peptide Sequence and Branching by Welser, Katharina, Campbell, Frederick, Kudsiova, Laila, Mohammadi, Atefeh, Dawson, Natalie, Hart, Stephen L, Barlow, David J, Hailes, Helen C, Lawrence, M. Jayne, Tabor, Alethea B

“…Cationic peptide sequences, whether linear, branched, or dendritic, are widely used to condense and protect DNA in both polyplex and lipopolyplex gene delivery…”
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Enhancing and Reversing the Stereoselectivity of Escherichia coli Transketolase via Single-Point Mutations by Smith, Mark E. B., Hibbert, Edward G., Jones, Alexander B., Dalby, Paul A., Hailes, Helen C.

“…Chiral auxiliary methodology and chiral assays have been developed to establish the enantiomeric purities of erythrulose and 1,3‐dihydroxypentan‐2‐one…”
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