Search Results - "HAIGWOOD, Nancy L"

Use of broadly neutralizing antibodies for HIV‐1 prevention by Pegu, Amarendra, Hessell, Ann J., Mascola, John R., Haigwood, Nancy L.

“…Summary Antibodies have a long history in antiviral therapy, but until recently, they have not been actively pursued for HIV‐1 due to modest potency and…”
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Passive and active antibody studies in primates to inform HIV vaccines by Hessell, Ann J, Malherbe, Delphine C, Haigwood, Nancy L

“…Prevention of infection remains the ultimate goal for HIV vaccination, and there is compelling evidence that antibodies directed to Envelope are necessary to…”
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Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques by Wen, Jing, Cheever, Tracy, Wang, Lan, Wu, Di, Reed, Jason, Mascola, John, Chen, Xuejun, Liu, Cuiping, Pegu, Amarendra, Sacha, Jonah B, Lu, Yunfeng, Haigwood, Nancy L, Chen, Irvin S. Y

“…Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central…”
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Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis by Spencer, David A., Goldberg, Benjamin S., Pandey, Shilpi, Ordonez, Tracy, Dufloo, Jérémy, Barnette, Philip, Sutton, William F., Henderson, Heidi, Agnor, Rebecca, Gao, Lina, Bruel, Timothée, Schwartz, Olivier, Haigwood, Nancy L., Ackerman, Margaret E., Hessell, Ann J.

“…Increasingly, antibodies are being used to treat and prevent viral infections. In the context of HIV, efficacy is primarily attributed to dose-dependent…”
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Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity by Shapiro, Mariya B., Cheever, Tracy, Malherbe, Delphine C., Pandey, Shilpi, Reed, Jason, Yang, Eun Sung, Wang, Keyun, Pegu, Amarendra, Chen, Xuejun, Siess, Don, Burke, David, Henderson, Heidi, Lewinsohn, Rebecca, Fischer, Miranda, Stanton, Jeffrey J., Axthelm, Michael K., Kahl, Christoph, Park, Byung, Lewis, Anne D., Sacha, Jonah B., Mascola, John R., Hessell, Ann J., Haigwood, Nancy L.

“…Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to abrogate infection…”
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Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines by Weiss, Svenja, Itri, Vincenza, Pan, Ruimin, Jiang, Xunqing, Luo, Christina C., Morris, Lynn, Malherbe, Delphine C., Barnette, Philip, Alexander, Jeff, Kong, Xiang-Peng, Haigwood, Nancy L., Hessell, Ann J., Duerr, Ralf, Zolla-Pazner, Susan

“…V2p and V2i antibodies (Abs) that are specific for epitopes in the V1V2 region of the HIV gp120 envelope (Env) do not effectively neutralize HIV but mediate…”
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Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques by Burwitz, Benjamin J., Wettengel, Jochen M., Mück-Häusl, Martin A., Ringelhan, Marc, Ko, Chunkyu, Festag, Marvin M., Hammond, Katherine B., Northrup, Mina, Bimber, Benjamin N., Jacob, Thomas, Reed, Jason S., Norris, Reed, Park, Byung, Moller-Tank, Sven, Esser, Knud, Greene, Justin M., Wu, Helen L., Abdulhaqq, Shaheed, Webb, Gabriela, Sutton, William F., Klug, Alex, Swanson, Tonya, Legasse, Alfred W., Vu, Tania Q., Asokan, Aravind, Haigwood, Nancy L., Protzer, Ulrike, Sacha, Jonah B.

“…Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack…”
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Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic by Spencer, David A., Shapiro, Mariya B., Haigwood, Nancy L., Hessell, Ann J.

“…Despite substantial progress in confronting the global HIV-1 epidemic since its inception in the 1980s, better approaches for both treatment and prevention…”
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Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques by Haigwood, Nancy L, Ng, Cherie T, Jaworski, J Pablo, Jayaraman, Pushpa, Sutton, William F, Delio, Patrick, Kuller, LaRene, Anderson, David, Landucci, Gary, Richardson, Barbra A, Burton, Dennis R, Forthal, Donald N

“…Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG,…”
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Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials by Balasubramanian, Preetha, Williams, Constance, Shapiro, Mariya B., Sinangil, Faruk, Higgins, Keith, Nádas, Arthur, Totrov, Maxim, Kong, Xiang-Peng, Fiore-Gartland, Andrew J., Haigwood, Nancy L., Zolla-Pazner, Susan, Hioe, Catarina E.

“…Immunization with HIV AIDSVAX gp120 vaccines in the phase III VAX003 and VAX004 trials did not confer protection. To understand the shortcomings in antibody…”
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Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Partially Mimics the In Vivo Development of Neutralizing Antibodies by MALHERBE, Delphine C, DORIA-ROSE, Nicole A, BARNETT, Susan, STAMATATOS, Leonidas, HAIGWOOD, Nancy L, MISHER, Lynda, BECKETT, Travis, BLAY PURYEAR, Wendy, SCHUMAN, Jason T, KRAFT, Zane, O'MALLEY, Jean, MORI, Motomi, SRIVASTAVA, Indresh

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Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor by Spencer, David A, Malherbe, Delphine C, Vázquez Bernat, Néstor, Ádori, Monika, Goldberg, Benjamin, Dambrauskas, Nicholas, Henderson, Heidi, Pandey, Shilpi, Cheever, Tracy, Barnette, Philip, Sutton, William F, Ackerman, Margaret E, Kobie, James J, Sather, D Noah, Karlsson Hedestam, Gunilla B, Haigwood, Nancy L, Hessell, Ann J

“…Vaccine efforts to combat HIV are challenged by the global diversity of viral strains and shielding of neutralization epitopes on the viral envelope…”
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Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates by Rosenberg, Yvonne J, Ordonez, Tracy, Khanwalkar, Urjeet S, Barnette, Philip, Pandey, Shilpi, Backes, Iara M, Otero, Claire E, Goldberg, Benjamin S, Crowley, Andrew R, Leib, David A, Shapiro, Mariya B, Jiang, Xiaoming, Urban, Lori A, Lees, Jonathan, Hessell, Ann J, Permar, Sallie, Haigwood, Nancy L, Ackerman, Margaret E

“…Transplacental transfer of maternal antibodies provides the fetus and newborn with passive protection against infectious diseases. While the role of the highly…”
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Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA by Krebs, Shelly J, McBurney, Sean P, Kovarik, Dina N, Waddell, Chelsea D, Jaworski, J Pablo, Sutton, William F, Gomes, Michelle M, Trovato, Maria, Waagmeester, Garret, Barnett, Susan J, DeBerardinis, Piergiuseppe, Haigwood, Nancy L

“…Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the…”
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Continuous Viral Escape and Selection by Autologous Neutralizing Antibodies in Drug-Naïve Human Immunodeficiency Virus Controllers by MAHALANABIS, Madhumita, JAYARAMAN, Pushpa, MIURA, Toshiyuki, PEREYRA, Florencia, CHESTER, E. Michael, RICHARDSON, Barbra, WALKER, Bruce, HAIGWOOD, Nancy L

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Induction of neutralizing antibodies in rhesus macaques using V3 mimotope peptides by Hessell, Ann J, McBurney, Sean, Pandey, Shilpi, Sutton, William, Liu, Lily, Li, Liuzhe, Totrov, Maxim, Zolla-Pazner, Susan, Haigwood, Nancy L, Gorny, Miroslaw K

“…Abstract RV144 vaccinees with low HIV-1 Envelope-specific IgA antibodies (Abs) also had Abs directed to the hypervariable region 3 (V3) that inversely…”
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Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth by Chukwuma, Valentine U, Kose, Nurgun, Sather, D Noah, Sapparapu, Gopal, Falk, Rachel, King, Hannah, Singh, Vidisha, Lampley, Rebecca, Malherbe, Delphine C, Ditto, Noah T, Sullivan, Jonathan T, Barnes, Trevor, Doranz, Benjamin J, Labranche, Celia C, Montefiori, David C, Kalams, Spyros A, Haigwood, Nancy L, Crowe, Jr, James E

“…Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs…”
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Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development by Malherbe, Delphine C, Wibmer, Constantinos Kurt, Nonyane, Molati, Reed, Jason, Sather, D Noah, Spencer, David A, Schuman, Jason T, Guo, Biwei, Pandey, Shilpi, Robins, Harlan, Park, Byung, Fuller, Deborah H, Sacha, Jonah B, Moore, Penny L, Hessell, Ann J, Haigwood, Nancy L

“…We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy…”
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CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques by Sarkar, Sanghita, Spencer, David A, Barnette, Philip, Pandey, Shilpi, Sutton, William F, Basu, Madhubanti, Burch, Reuben E, Cleveland, John D, Rosenberg, Alexander F, Rangel-Moreno, Javier, Keefer, Michael C, Hessell, Ann J, Haigwood, Nancy L, Kobie, James J

“…Induction of broadly neutralizing antibodies (bNAbs) is a major goal for HIV vaccine development. HIV envelope glycoprotein (Env)-specific bNAbs isolated from…”
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High Specific Infectivity of Plasma Virus from the Pre-Ramp-Up and Ramp-Up Stages of Acute Simian Immunodeficiency Virus Infection by MA, Zhong-Min, STONE, Mars, PIATAK, Mike, SCHWEIGHARDT, Becky, HAIGWOOD, Nancy L, MONTEFIORI, David, LIFSON, Jeffrey D, BUSCH, Michael P, MILLER, Christopher J

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