Search Results - "HAIGH, J. R"

Gas concentration effects on secondary metabolite production by plant cell cultures by Linden, J C, Haigh, J R, Mirjalili, N, Phisaphalong, M

“…One aspect of secondary metabolite production that has been studied relatively infrequently is the effect of gaseous compounds on plant cell behavior. The most…”
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Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle : implications for glucose metabolism by SHEPHERD, P. R, NAVE, B. T, RINCON, J, HAIGH, R. L, FOULSTONE, E, PROUD, C, ZIERATH, J. R, SIDDLE, K, WALLBERG-HENRIKSSON, H

“…Isolated skeletal muscle from healthy individuals was used to evaluate the role of phosphoinositide 3-kinase (PI 3-kinase) in insulin signalling pathways…”
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Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells by BASKARAN RAMACHANDRAN, HOUBEN, K, ROZENBERG, Y. Y, HAIGH, J. R, VARPETIAN, A, HOWARD, B. D

“…Wild type PC12 pheochromocytoma cells express a Na(+)-dependent norepinephrine transporter that operates in the uptake of catecholamines, including dopamine…”
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Poor compliance is a major factor in unstable outpatient control of anticoagulant therapy by Kumar, S, Haigh, J R, Rhodes, L E, Peaker, S, Davies, J A, Roberts, B E, Feely, M P

“…Control of oral anticoagulant therapy in outpatients is often unsatisfactory. The contribution of poor compliance with prescribed warfarin to unstable…”
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Scopolamine and benzodiazepine models of dementia: cross-reversals by Ro 15-1788 and physostigmine by PRESTON, G. C, WARD, C, LINES, C. R, POPPLETON, P, HAIGH, J. R. M, TRAUB, M

“…The muscarinic antagonist scopolamine and the benzodiazepine lorazepam both produce transient impairments in memory and attention in normal volunteers. These…”
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Effect of warfarin on plasma concentrations of vitamin K dependent coagulation factors in patients with stable control and monitored compliance by Kumar, S, Haigh, J R, Tate, G, Boothby, M, Joanes, D N, Davies, J A, Roberts, B E, Feely, M P

“…There is a discrepancy in the results of reported studies of levels of vitamin K dependent coagulation factors in patients on warfarin therapy. This may have…”
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Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes by Navé, B T, Haigh, R J, Hayward, A C, Siddle, K, Shepherd, P R

“…To understand how the stimulation of phosphoinositide 3-kinase (PI 3-kinase) by different growth factors can activate different subsets of downstream…”
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Tolerance to the anticonvulsant effect of clonazepam in mice: no concurrent change in plasma concentration by Haigh, J R, Feely, M, Gent, J P

“…Clonazepam was administered for 10 or more days on three different dose regimens (0.5, 0.25 and 0.08 mg kg-1 twice daily) to mice given pentetrazol by slow…”
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The role of phosphatidylinositol 3-kinase activity in insulin-stimulated mitogenesis in 3T3-L1 adipocytes by Haigh, R J, Shepherd, P R, Navé, B T, Siddle, K

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N‐desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy? by Haigh, JR, Pullar, T, Gent, JP, Dailley, C, Feely, M

“…The development of anticonvulsant tolerance during 10 days treatment with either clobazam or its principal metabolite, N‐desmethylclobazam (NDMC), was compared…”
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A theory of warm prestressing: experimental validation and the implications for elastic plastic failure criteria by Chell, G G, Haigh, J R, Vitek, V

“…A theoretical explanation of warm prestressing (WPS) is proposed based on the J-integral. This is defined so that only elastic strains and distortions are…”
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Plasma concentrations of clobazam and its N-desmethyl metabolite; protection against pentetrazol-induced convulsions in mice by Haigh, J R, Gent, J P, Calvert, R

“…The anticonvulsant effects of acute administration of clobazam and its principal metabolite N-desmethylclobazam were studied in mice. Pentetrazol, given by…”
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Pentagastrin induced panic attacks : enhanced sensitivity in panic disorder patients by VAN MEGEN, H. J. G. M, WESTENBERG, H. G. M, DEN BOER, J. A, HAIGH, J. R. M, TRAUB, M

“…The effects of pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK4), were studied in 15 patients with panic disorder and 15 healthy…”
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Pharmacokinetics of N‐desmethylclobazam in healthy volunteers and patients with epilepsy by Pullar, T, Haigh, JR, Peaker, S, Feely, MP

“…1. The single dose pharmacokinetics of N‐desmethylclobazam (NDMC) and clobazam were studied in eight healthy male volunteers. 2. Steady‐state pharmacokinetic…”
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The effect of allopurinol on the steady‐state pharmacokinetics of indomethacin by Pullar, T., Myall, O., Haigh, J.R., Lowe, J.R., Dixon, JS, Bird, HA

“…The effect of 5 days treatment with allopurinol (300 mg) on the pharmacokinetics of indomethacin at steady‐state was investigated in eight patients…”
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The effect of cimetidine on the single dose pharmacokinetics of oral clobazam and N‐desmethylclobazam by Pullar, T, Edwards, D, Haigh, JR, Peaker, S, Feely, MP

“…The effect of cimetidine on the single dose pharmacokinetics of orally administered clobazam and N‐desmethylclobazam (NDMC) was studied in volunteers…”
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Penile verrucous carcinoma by McKee, P H, Lowe, D, Haigh, R J

“…Eleven patients with verrucous carcinoma of the penis are presented. The age range was from 41 to 80 years with a mean of 59 years. The pathological features…”
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RO 16-6028, a benzodiazepine receptor partial agonist, does not exhibit anticonvulsant tolerance in mice by Haigh, J R, Feely, M

“…The development of anticonvulsant tolerance with RO 16-6028, a benzodiazepine receptor partial agonist, was assessed in mice using an i.v. infusion of…”
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Free concentrations of sodium, potassium and calcium in chromaffin granules by Haigh, J R, Parris, R, Phillips, J H

“…We have measured the contents of Na+ and K+ in isolated chromaffin granules. Total contents varied between 227 and 283 nmol/mg of protein, equivalent to matrix…”
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The effects of simvastatin and pravastatin on objective and subjective measures of nocturnal sleep : a comparison of two structurally different HMG CoA reductase inhibitors in patients with primary moderate hypercholesterolaemia by ECKERNÄS, S.-Å, ROOS, B.-E, KVIDAL, P, ERIKSSON, L.-O, BLOCK, G. A, NEAFUS, R. P, HAIGH, J. R. M

“…1. It has been suggested that HMG CoA reductase inhibitors which are administered as inactive, lipophilic lactones (e.g. simvastatin) have a greater propensity…”
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