Search Results - "HAHNFELDT, Philip"

The Emerging Hallmarks of Metabolic Reprogramming and Immune Evasion: Distinct or Linked? by KAREVA, Irina, HAHNFELDT, Philip

“…The role of the immune system in tumor elimination has been shown to be increasingly ambiguous, as many tumors not only escape recognition by the adaptive…”
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Classical mathematical models for description and prediction of experimental tumor growth by Benzekry, Sébastien, Lamont, Clare, Beheshti, Afshin, Tracz, Amanda, Ebos, John M L, Hlatky, Lynn, Hahnfeldt, Philip

“…Despite internal complexity, tumor growth kinetics follow relatively simple laws that can be expressed as mathematical models. To explore this further,…”
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Evolution and phenotypic selection of cancer stem cells by Poleszczuk, Jan, Hahnfeldt, Philip, Enderling, Heiko

“…Cells of different organs at different ages have an intrinsic set of kinetics that dictates their behavior. Transformation into cancer cells will inherit these…”
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Therapeutic implications from sensitivity analysis of tumor angiogenesis models by Poleszczuk, Jan, Hahnfeldt, Philip, Enderling, Heiko

“…Anti-angiogenic cancer treatments induce tumor starvation and regression by targeting the tumor vasculature that delivers oxygen and nutrients. Mathematical…”
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Global dormancy of metastases due to systemic inhibition of angiogenesis by Benzekry, Sébastien, Gandolfi, Alberto, Hahnfeldt, Philip

“…Autopsy studies of adults dying of non-cancer causes have shown that virtually all of us possess occult, cancerous lesions. This suggests that, for most…”
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A Multicompartment Mathematical Model of Cancer Stem Cell-Driven Tumor Growth Dynamics by Weekes, Suzanne L., Barker, Brian, Bober, Sarah, Cisneros, Karina, Cline, Justina, Thompson, Amanda, Hlatky, Lynn, Hahnfeldt, Philip, Enderling, Heiko

“…Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying proliferation capacities and tumorigenic potentials. As a central…”
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Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion by Wilkie, Kathleen P., Hahnfeldt, Philip

“…Cancer dormancy, a state in which cancer cells persist in a host without significant growth, is a natural forestallment of progression to manifest disease and…”
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Transcriptional network governing the angiogenic switch in human pancreatic cancer by Abdollahi, Amir, Schwager, Christian, Kleeff, Jörg, Esposito, Irene, Domhan, Sophie, Peschke, Peter, Hauser, Kai, Hahnfeldt, Philip, Hlatky, Lynn, Debus, Jürgen, Peters, Jeffrey M, Friess, Helmut, Folkman, Judah, Huber, Peter E

“…A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression. Here we devise a strategy…”
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A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation by Shuryak, Igor, Hahnfeldt, Philip, Hlatky, Lynn, Sachs, Rainer K., Brenner, David J.

“…As the number of cancer survivors grows, prediction of radiotherapy-induced second cancer risks becomes increasingly important. Because the latency period for…”
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Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue by Wage, Justin, Ma, Lili, Peluso, Michael, Lamont, Clare, Evens, Andrew M., Hahnfeldt, Philip, Hlatky, Lynn, Beheshti, Afshin

“…Age plays a crucial role in the interplay between tumor and host, with additional impact due to irradiation. Proton irradiation of tumors induces biological…”
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Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype by Enderling, Heiko, Hlatky, Lynn, Hahnfeldt, Philip

“…Aside from the stepwise genetic alterations known to underlie cancer cell creation, the microenvironment is known to profoundly influence subsequent tumor…”
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A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: Approach by Shuryak, Igor, Hahnfeldt, Philip, Hlatky, Lynn, Sachs, Rainer K., Brenner, David J.

“…Mathematical models of radiation carcinogenesis are important for understanding mechanisms and for interpreting or extrapolating risk. There are two classes of…”
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A Proposed Quantitative Index for Assessing the Potential Contribution of Reprogramming to Cancer Stem Cell Kinetics by Hahnfeldt, Philip, Naidu, Mamta, McDonald, J. Tyson, Gao, Xuefeng, Hlatky, Lynn

“…Enrichment of cancer stem cells (CSCs) is thought to be responsible for glioblastoma multiforme (GBM) recurrence after radiation therapy. Simulation results…”
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Evaluating biomarkers to model cancer risk post cosmic ray exposure by Sridharan, Deepa M., Asaithamby, Aroumougame, Blattnig, Steve R., Costes, Sylvain V., Doetsch, Paul W., Dynan, William S., Hahnfeldt, Philip, Hlatky, Lynn, Kidane, Yared, Kronenberg, Amy, Naidu, Mamta D., Peterson, Leif E., Plante, Ianik, Ponomarev, Artem L., Saha, Janapriya, Snijders, Antoine M., Srinivasan, Kalayarasan, Tang, Jonathan, Werner, Erica, Pluth, Janice M.

“…Robust predictive models are essential to manage the risk of radiation-induced carcinogenesis. Chronic exposure to cosmic rays in the context of the complex…”
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Radiation-Induced Reprogramming of Pre-Senescent Mammary Epithelial Cells Enriches Putative CD44+/CD24−/low Stem Cell Phenotype by Gao, Xuefeng, Sishc, Brock J., Nelson, Christopher B., Hahnfeldt, Philip, Bailey, Susan M., Hlatky, Lynn

“…The enrichment of putative CD44 + /CD24 −/low breast stem cell populations following exposure to ionizing radiation (IR) has been ascribed to their inherent…”
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Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth by Benzekry, Sebastien, Beheshti, Afshin, Hahnfeldt, Philip, Hlatky, Lynn

“…In 1999, Hahnfeldt . proposed a mathematical model for tumor growth as dictated by reciprocal communications between tumor and its associated vasculature,…”
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A mathematical model of systemic inhibition of angiogenesis in metastatic development by Dhersin, Jean-Stéphane, Benzekry, Sébastien, Gandolfi, Alberto, Hahnfeldt, Philip

“…We present a mathematical model describing the time development of a population of tumors subject to mutual angiogenic inhibitory signaling. Based on…”
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The host support niche as a control point for tumor dormancy: implications for tumor development and beyond by Hahnfeldt, Philip

“…An increasingly appreciated focus of carcinogenesis research is on mechanisms governing tumor growth after the fact of cancer cell creation. Of particular…”
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Cancer stem cells in solid tumors: Is ‘evading apoptosis’ a hallmark of cancer? by Enderling, Heiko, Hahnfeldt, Philip

“…Conventional wisdom has long held that once a cancer cell has developed it will inevitably progress to clinical disease. Updating this paradigm, it has more…”
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The Tumor Growth Paradox and Immune System-Mediated Selection for Cancer Stem Cells by Hillen, Thomas, Enderling, Heiko, Hahnfeldt, Philip

“…Cancer stem cells (CSCs) drive tumor progression, metastases, treatment resistance, and recurrence. Understanding CSC kinetics and interaction with their…”
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