Search Results - "HAGIWARA, Shinji"

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7 by McClelland, Aaron D, Herman-Edelstein, Michal, Komers, Radko, Jha, Jay C, Winbanks, Catherine E, Hagiwara, Shinji, Gregorevic, Paul, Kantharidis, Phillip, Cooper, Mark E

“…The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic nephropathy (DN) with data implicating the miRNA (miR) miR-21 as a key…”
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Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice by Murakoshi, Maki, Gohda, Tomohito, Adachi, Eri, Ichikawa, Saki, Hagiwara, Shinji, Suzuki, Yusuke

“…Progranulin (PGRN) has been reported to bind tumor necrosis factor (TNF) receptor and to inhibit TNFα signaling. We evaluated the effect of augmentation of…”
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Potential Targeting of Renal Fibrosis in Diabetic Kidney Disease Using MicroRNAs by Sakuma, Hiroko, Hagiwara, Shinji, Kantharidis, Phillip, Gohda, Tomohito, Suzuki, Yusuke

“…Diabetic kidney disease (DKD) is a major health problem and one of the leading causes of end-stage renal disease worldwide. Despite recent advances, there…”
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Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b by Wang, Bo, Jha, Jay C, Hagiwara, Shinji, McClelland, Aaron D, Jandeleit-Dahm, Karin, Thomas, Merlin C, Cooper, Mark E, Kantharidis, Phillip

“…Renal fibrosis results from excessive accumulation of extracellular matrix mainly driven by transforming growth factor-β1 (TGF-β1). Certain microRNAs have been…”
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Potential of Modulating Aldosterone Signaling and Mineralocorticoid Receptor with microRNAs to Attenuate Diabetic Kidney Disease by Hagiwara, Shinji, Gohda, Tomohito, Kantharidis, Phillip, Okabe, Jun, Murakoshi, Maki, Suzuki, Yusuke

“…Diabetic Kidney Disease (DKD) is a significant complication of diabetes and primary cause of end-stage renal disease globally. The exact mechanisms underlying…”
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A Liposomal Gemcitabine, FF-10832, Improves Plasma Stability, Tumor Targeting, and Antitumor Efficacy of Gemcitabine in Pancreatic Cancer Xenograft Models by Matsumoto, Takeshi, Komori, Takashi, Yoshino, Yuta, Ioroi, Tadaaki, Kitahashi, Tsukasa, Kitahara, Hiromu, Ono, Kohei, Higuchi, Tamami, Sakabe, Masayo, Kori, Hiroshi, Kano, Masahiro, Hori, Ritsuko, Kato, Yukio, Hagiwara, Shinji

“…Purpose The clinical application of gemcitabine (GEM) is limited by its pharmacokinetic properties. The aim of this study was to characterize the stability in…”
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Intermittent Akinetic Mutism after Bilateral Paramedian Thalamic Infarction Caused by Artery of Percheron Occlusion:A Case Report by Imazato, Daisuke, Kubota, Yuichi, Ebise, Hiroki, Yokosako, Suguru, Arai, Naoyuki, Hagiwara, Shinji, Ohbuchi, Hidenori

“…Intermittent clinical course of akinetic mutism is very unusual. We describe a 74-year-old man who started to demonstrate episodes of altered mental state with…”
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Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation by Nakatani, Keisuke, Maehama, Tomohiko, Nishio, Miki, Otani, Junji, Yamaguchi, Keiko, Fukumoto, Miki, Hikasa, Hiroki, Hagiwara, Shinji, Nishina, Hiroshi, Mak, Tak Wah, Honma, Teruki, Kondoh, Yasumitsu, Osada, Hiroyuki, Yoshida, Minoru, Suzuki, Akira

“…Yes‐associated protein 1 (YAP1) and its paralogue PDZ‐binding motif (TAZ) play pivotal roles in cell proliferation, migration, and invasion, and abnormal…”
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Association of Therapeutic Intervention With Activities of Daily Living in Patients With Unruptured Intracranial Aneurysms During the Follow-up Period: Propensity Score-Matched Cohort Analysis by Arai, Naoyuki, Yoneyama, Taku, Sato, Yasunori, Ohbuchi, Hidenori, Hagiwara, Shinji, Kasuya, Hidetoshi

“…Background: We sought to evaluate the clinical outcomes and association of therapeutic intervention with activities of daily living (ADL) in patients with…”
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Nonconvulsive status epilepticus as sign of tumor recurrence by Nishiyama, Kae, Kubota, Yuichi, Ohbuchi, Hidenori, Yokosako, Suguru, Hagiwara, Shinji

“…•Nonconvulsive status epilepticus may be a sign of tumor recurrence.•When seizure is uncontrolled with adequate medication, tumor excision should be considered…”
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Fractional excretion of tumor necrosis factor receptor 1 and 2 in patients with type 2 diabetes and normal renal function by Gohda, Tomohito, Kamei, Nozomu, Kubota, Mitsunobu, Tanaka, Kanako, Yamashita, Yoshinori, Sakuma, Hiroko, Kishida, Chiaki, Adachi, Eri, Koshida, Takeo, Murakoshi, Maki, Hagiwara, Shinji, Funabiki, Kazuhiko, Ueda, Seiji, Suzuki, Yusuke

“…Aims/Introduction Increased concentrations of serum tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2) are positively associated with the urinary…”
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MicroRNA in Diabetic Nephropathy : Renin Angiotensin, AGE/RAGE, and Oxidative Stress Pathway by Hagiwara, Shinji, Kantharidis, Phillip, McClelland, Aaron

“…MicroRNAs (miRNA) are a novel class of small, noncoding RNA molecules that have gained the attention of many researchers in recent years due to their ability…”
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AGE–RAGE interaction and oxidative stress in obesity-related renal dysfunction by Tomino, Yasuhiko, Hagiwara, Shinji, Gohda, Tomohito

“…Obesity is a risk factor for development of kidney disease. Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) play important roles in the…”
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FF‐10832 enables long survival via effective gemcitabine accumulation in a lethal murine peritoneal dissemination model by Higuchi, Tamami, Yokobori, Takehiko, Takahashi, Ryo, Naito, Tomoharu, Kitahara, Hiromu, Matsumoto, Takeshi, Kakinuma, Chihaya, Hagiwara, Shinji, Kuwano, Hiroyuki, Shirabe, Ken, Asao, Takayuki

“…Chemotherapy has been the treatment of choice for unresectable peritoneal dissemination; however, it is difficult to eradicate such tumors because of poor drug…”
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MicroRNA as biomarkers and regulator of cardiovascular development and disease by Hagiwara, Shinji, Kantharidis, Phillip, Cooper, Mark E

“…MicroRNAs are small noncoding RNAs that have emerged as important regulators of many biological and pathological processes, including those relevant to the…”
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Clinical predictors of intracranial injuries in infants with minor head trauma by Ohbuchi, Hidenori, MD, Hagiwara, Shinji, MD, Hirota, Kengo, MD, Koseki, Hirokazu, MD, Kuroi, Yasuhiro, MD, Arai, Naoyuki, MD, Kasuya, Hidetoshi, MD

“…Abstract Objective Minor head trauma is common in children. Though most cases are nonsignificant, minor head trauma can lead to the deterioration of…”
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Sensitivity of CT perfusion for the diagnosis of cerebral infarction by Hana, Taijun, Iwama, Junya, Yokosako, Suguru, Yoshimura, Chika, Arai, Naoyuki, Kuroi, Yasuhiro, Koseki, Hirokazu, Akiyama, Mami, Hirota, Kengo, Ohbuchi, Hidenori, Hagiwara, Shinji, Tani, Shigeru, Sasahara, Atsushi, Kasuya, Hidetoshi

“…We aimed to determine the sensitivity of CT perfusion (CTP) for the diagnosis of cerebral infarction in the acute stage. We retrospectively reviewed patients…”
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Effects of pyridoxamine (K-163) on glucose intolerance and obesity in high-fat diet C57BL/6J mice by Hagiwara, Shinji, Gohda, Tomohito, Tanimoto, Mitsuo, Ito, Takamichi, Murakoshi, Maki, Ohara, Ikko, Yamazaki, Takahiko, Matsumoto, Masakazu, Horikoshi, Satoshi, Funabiki, Kazuhiko, Tomino, Yasuhiko

“…Abstract Advanced glycation end products (AGEs) contribute to the pathogenesis of diabetes-associated complications. Previously, we reported the possible…”
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Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-A (y) Mouse by Furukawa, Masako, Gohda, Tomohito, Hagiwara, Shinji, Tanimoto, Mitsuo, Horikoshi, Satoshi, Funabiki, Kazuhiko, Tomino, Yasuhiko

“…Objective. Although angiotensin II-mediated inflammation and extracellular matrix accumulation are considered to be associated with the progression of diabetic…”
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Identifying and interpreting novel targets that address more than one diabetic complication: a strategy for optimal end organ protection in diabetes by Hagiwara, Shinji, Jha, Jay C., Cooper, Mark E.

“…It is increasingly appreciated that subjects with diabetes who develop one vascular complication are more likely to also suffer from another complication. For…”
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