Search Results - "HAGEMEIJER, Anne"

Low-Dose Decitabine Versus Best Supportive Care in Elderly Patients With Intermediate- or High-Risk Myelodysplastic Syndrome (MDS) Ineligible for Intensive Chemotherapy: Final Results of the Randomized Phase III Study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group by LÜBBERT, Michael, SUCIU, Stefan, BEELDENS, Filip, MUUS, Petra, PFLÜGER, Karl-Heinz, COENS, Corneel, HAGEMEIJER, Anne, ECKART SCHAEFER, Hans, GANSER, Arnold, AUL, Carlo, DE WITTE, Theo, WIJERMANS, Pierre W, BAILA, Liliana, RÜTER, Björn Hans, PLATZBECKER, Uwe, GIAGOUNIDIS, Aristoteles, SELLESLAG, Dominik, LABAR, Boris, GERMING, Ulrich, SALIH, Helmut R

“…To compare low-dose decitabine to best supportive care (BSC) in higher-risk patients with myelodysplastic syndrome (MDS) age 60 years or older and ineligible…”
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Acquired mutations in TET2 are common in myelodysplastic syndromes by Jansen, Joop H, Langemeijer, Saskia M C, Kuiper, Roland P, Berends, Marieke, Knops, Ruth, Aslanyan, Mariam G, Massop, Marion, Stevens-Linders, Ellen, van Hoogen, Patricia, van Kessel, Ad Geurts, Raymakers, Reinier A P, Kamping, Eveline J, Verhoef, Gregor E, Verburgh, Estelle, Hagemeijer, Anne, Vandenberghe, Peter, de Witte, Theo, van der Reijden, Bert A

“…Myelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic hematopoietic disorders. Several recurrent chromosomal aberrations have been…”
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Monosomal Karyotype in Acute Myeloid Leukemia: A Better Indicator of Poor Prognosis Than a Complex Karyotype by BREEMS, Dimitri A, VAN PUTTEN, Wim L. J, LOWENBERG, Bob, DE GREEF, Georgine E, VAN ZELDEREN-BHOLA, Shama L, GERSSEN-SCHOORL, Klasien B. J, MELLINK, Clemens H. M, NIEUWINT, Aggie, JOTTERAND, Martine, HAGEMEIJER, Anne, BERNA BEVERLOO, H

“…To investigate the prognostic value of various cytogenetic components of a complex karyotype in acute myeloid leukemia (AML). Cytogenetics and overall survival…”
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A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy by LÜBBERT, Michael, RÜTER, Björn H, GALM, Oliver, BRUGGER, Wolfram, HEIL, Gerhard, HACKANSON, Björn, DESCHLER, Barbara, DÖHNER, Konstanze, HAGEMEIJER, Anne, WIJERMANS, Pierre W, DÖHNER, Hartmut, CLAUS, Rainer, SCHMOOR, Claudia, SCHMID, Mathias, GERMING, Ulrich, KUENDGEN, Andrea, RETHWISCH, Volker, GANSER, Arnold, PLATZBECKER, Uwe

“…The treatment of acute myeloid leukemia of older, medically non-fit patients still poses a highly unmet clinical need, and only few large, prospective studies…”
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Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants by Debiec-Rychter, Maria, Cools, Jan, Dumez, Herlinde, Sciot, Raf, Stul, Michel, Mentens, Nicole, Vranckx, Hilde, Wasag, Bartosz, Prenen, Hans, Roesel, Johannes, Hagemeijer, Anne, Van Oosterom, Allan, Marynen, Peter

“…Background & Aims: Resistance is a major challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). We investigated the mechanisms of…”
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Impact of induction regimen and allogeneic hematopoietic cell transplantation on outcome in younger adults with acute myeloid leukemia with a monosomal karyotype by Baron, Frédéric, Stevens-Kroef, Marian, Kicinski, Michal, Meloni, Giovanna, Muus, Petra, Marie, Jean-Pierre, Halkes, Constantijn J M, Thomas, Xavier, Vrhovac, Radovan, Albano, Francesco, Lefrère, Sr, François, Sica, Simona, Mancini, Marco, Venditti, Adriano, Hagemeijer, Anne, Jansen, Joop H, Amadori, Sergio, de Witte, Theo, Willemze, Roelof, Suciu, Stefan

“…Monosomal karyotype confers a poor prognosis in patients with acute myeloid leukemia. Here, we determined the impact of the type of remission-induction…”
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Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) by Akasaka, Takashi, Balasas, Theodore, Russell, Lisa J., Sugimoto, Kei-ji, Majid, Aneela, Walewska, Renata, Karran, E. Loraine, Brown, David G., Cain, Kelvin, Harder, Lana, Gesk, Stefan, Martin-Subero, Jose Ignacio, Atherton, Mark G., Brüggemann, Monika, Calasanz, María José, Davies, Teresa, Haas, Oskar A., Hagemeijer, Anne, Kempski, Helena, Lessard, Michel, Lillington, Debra M., Moore, Sarah, Nguyen-Khac, Florence, Radford-Weiss, Isabelle, Schoch, Claudia, Struski, Stéphanie, Talley, Polly, Welham, Melanie J., Worley, Helen, Strefford, Jon C., Harrison, Christine J., Siebert, Reiner, Dyer, Martin J.S.

“…CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid…”
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Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. Final results of a prospective randomized European Intergroup Trial by DE WITTE, Theo, HAGEMEIJER, Anne, AMADORI, Sergio, MUUS, Petra, JANSEN, Joop H, HELLSTRÖM-LINDBERG, Eva, KOVACSOVICS, Tibor, WIJERMANS, Pierre, OSSENKOPPELE, Gert, GRATWOHL, Alois, MARIE, Jean-Pierre, WILLEMZE, Roel, SUCIU, Stefan, BELHABRI, Amin, DELFORGE, Michel, KOBBE, Guido, SELLESLAG, Dominik, SCHOUTEN, Harry C, FERRANT, Augustin, BIERSACK, Harald

“…Allogeneic stem cell transplantation is usually considered the only curative treatment option for patients with advanced or transformed myelodysplastic…”
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Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor by Cools, Jan, Wlodarska, Iwona, Somers, Riet, Mentens, Nicole, Pedeutour, Florence, Maes, Brigitte, De Wolf-Peeters, Christiane, Pauwels, Patrick, Hagemeijer, Anne, Marynen, Peter

“…ALK‐positive anaplastic large‐cell lymphoma (ALCL) has been recognized as a distinct type of lymphoma in the heterogeneous group of T/Null‐ALCL. While most of…”
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MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene by Storlazzi, Clelia Tiziana, Fioretos, Thoas, Surace, Cecilia, Lonoce, Angelo, Mastrorilli, Angela, Strömbeck, Bodil, D'Addabbo, Pietro, Iacovelli, Francesco, Minervini, Crescenzio, Aventin, Anna, Dastugue, Nicole, Fonatsch, Christa, Hagemeijer, Anne, Jotterand, Martine, Mühlematter, Dominique, Lafage-Pochitaloff, Marina, Nguyen-Khac, Florence, Schoch, Claudia, Slovak, Marilyn L., Smith, Arabella, Solè, Francesc, Van Roy, Nadine, Johansson, Bertil, Rocchi, Mariano

“…Double minutes (dmin)—circular, extra-chromosomal amplifications of specific acentric DNA fragments—are relatively frequent in malignant disorders,…”
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Differential expression of KIT/PDGFRA mutant isoforms in epithelioid and mixed variants of gastrointestinal stromal tumors depends predominantly on the tumor site by Wasag, Bartosz, Debiec-Rychter, Maria, Pauwels, Patrick, Stul, Michel, Vranckx, Hilde, Oosterom, Allan Van, Hagemeijer, Anne, Sciot, Raf

“…Gastrointestinal stromal tumors (GISTs) form a distinctive group of mesenchymal neoplasms, showing differentiation towards the interstitial cells of Cajal…”
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ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor by Debiec-Rychter, Maria, Marynen, Peter, Hagemeijer, Anne, Pauwels, Patrick

“…In this report, we describe an inflammatory myofibroblastic tumor (IMT) of the urinary bladder in a 46‐year‐old man. Tumor cells presented striking…”
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The Leukemic Fusion Gene AML1-MDS1-EVI1 Suppresses CEBPA in Acute Myeloid Leukemia by Activation of Calreticulin by Helbling, Daniel, Mueller, Beatrice U., Timchenko, Nikolai A., Hagemeijer, Anne, Jotterand, Martine, Meyer-Monard, Sandrine, Lister, Andrew, Rowley, Janet D., Huegli, Barbara, Fey, Martin F., Pabst, Thomas

“…The leukemic fusion gene AML1-MDS1-EVI1 (AME) encodes a chimeric transcription factor that results from the t(3,21)(q26;q22) translocation seen in patients…”
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EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22 by De Weer, An, Speleman, Frank, Cauwelier, Barbara, Van Roy, Nadine, Yigit, Nurten, Verhasselt, Bruno, De Moerloose, Barbara, Benoit, Yves, Noens, Lucien, Selleslag, Dominik, Lippert, Eric, Struski, Stephanie, Bastard, Christian, De Paepe, Anne, Vandenberghe, Peter, Hagemeijer, Anne, Dastugue, Nicole, Poppe, Bruce, on behalf of Groupe Francais de Cytogenetique Hematologique (GFCH)

“…1 Centre for Medical Genetics Gent (CMGG), Ghent University Hospital, Ghent, Belgium 2 Department of Hematology, Hospital St-Jan, Bruges, Belgium 3 Department…”
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Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances by Franke, Sabine, Wlodarska, Iwona, Maes, Brigitte, Vandenberghe, Peter, Delabie, Jan, Hagemeijer, Anne, De Wolf-Peeters, Chris

“…Single-cell polymerase chain reaction (PCR) has been used as a tool to demonstrate clonality and B-cell origin of Reed-Sternberg (RS) cells in Hodgkin disease…”
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Histologic Localization of PLAG1 (Pleomorphic Adenoma Gene 1) in Pleomorphic Adenoma of the Salivary Gland: Cytogenetic Evidence of Common Origin of Phenotypically Diverse Cells by Debiec-Rychter, Maria, Van Valckenborgh, Isabelle, Van den Broeck, Christel, Hagemeijer, Anne, Van de Ven, Wim J M, Kas, Koen, Van Damme, Boudewijn, Voz, Marianne L

“…Pleomorphic adenoma gene 1 (PLAG1), a zinc finger transcription factor gene, is consistently rearranged and overexpressed in human pleomorphic adenomas of the…”
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The Cryptic inv(2)(p23q35) Defines a New Molecular Genetic Subtype of ALK-Positive Anaplastic Large-Cell Lymphoma by Wlodarska, Iwona, De Wolf-Peeters, Chris, Falini, Brunangelo, Verhoef, Gregor, Morris, Stephan W., Hagemeijer, Anne, Van denBerghe, Herman

“…Recently, a distinctive entity characterized by expression of the anaplastic lymphoma kinase (ALK) protein [most frequently due to the…”
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Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: Report from an International Workshop by Block, AnneMarie W., Carroll, Andrew J., Hagemeijer, Anne, Lucienne Michaux, van Lom, Kirsten, Olney, Harold J., Baer, Maria R.

“…Seventy‐seven patients were identified with Rare recurring (excluding 11q23, 21q22, inv(16), and t(15;17)) chromosome abnormalities among 511 patients with…”
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Gemtuzumab Ozogamicin Versus Best Supportive Care in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Unsuitable for Intensive Chemotherapy: Results of the Randomized Phase III EORTC-GIMEMA AML-19 Trial by Amadori, Sergio, Suciu, Stefan, Selleslag, Dominik, Aversa, Franco, Gaidano, Gianluca, Musso, Maurizio, Annino, Luciana, Venditti, Adriano, Voso, Maria Teresa, Mazzone, Carla, Magro, Domenico, De Fabritiis, Paolo, Muus, Petra, Alimena, Giuliana, Mancini, Marco, Hagemeijer, Anne, Paoloni, Francesca, Vignetti, Marco, Fazi, Paola, Meert, Liv, Ramadan, Safaa Mahmoud, Willemze, Roel, de Witte, Theo, Baron, Frédéric

“…To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute…”
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Fluorescence in situ hybridization characterization of new translocations involving TEL (ETV6) in a wide spectrum of hematologic malignancies by WLODARSKA, I, LA STARZA, R, MARYNEN, P, BAENS, M, DIERLAMM, J, UYTTEBROECK, A, SELLESLAG, D, FRANCINE, A, MECUCCI, C, HAGEMEIJER, A, VAN DEN BERGHE, H

“…The ETV6 (also known as TEL) gene on chromosome 12p13 is the target of a number of translocations associated with various hematologic malignancies. The…”
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