Search Results - "HAFNER, Markus"

Proximity-CLIP provides a snapshot of protein-occupied RNA elements in subcellular compartments by Benhalevy, Daniel, Anastasakis, Dimitrios G., Hafner, Markus

“…Methods for the systematic study of subcellular RNA localization are limited, and their development has lagged behind that of proteomic tools. We combined…”
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Characterizing Expression and Processing of Precursor and Mature Human tRNAs by Hydro-tRNAseq and PAR-CLIP by Gogakos, Tasos, Brown, Miguel, Garzia, Aitor, Meyer, Cindy, Hafner, Markus, Tuschl, Thomas

“…The participation of tRNAs in fundamental aspects of biology and disease necessitates an accurate, experimentally confirmed annotation of tRNA genes and…”
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Laboratory mice born to wild mice have natural microbiota and model human immune responses by Rosshart, Stephan P, Herz, Jasmin, Vassallo, Brian G, Hunter, Ashli, Wall, Morgan K, Badger, Jonathan H, McCulloch, John A, Anastasakis, Dimitrios G, Sarshad, Aishe A, Leonardi, Irina, Collins, Nicholas, Blatter, Joshua A, Han, Seong-Ji, Tamoutounour, Samira, Potapova, Svetlana, Foster St Claire, Mark B, Yuan, Wuxing, Sen, Shurjo K, Dreier, Matthew S, Hild, Benedikt, Hafner, Markus, Wang, David, Iliev, Iliyan D, Belkaid, Yasmine, Trinchieri, Giorgio, Rehermann, Barbara

“…Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by…”
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DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions by Sauer, Markus, Juranek, Stefan A., Marks, James, De Magis, Alessio, Kazemier, Hinke G., Hilbig, Daniel, Benhalevy, Daniel, Wang, Xiantao, Hafner, Markus, Paeschke, Katrin

“…Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box…”
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Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA by Brown, Rebecca S., Anastasakis, Dimitrios G., Hafner, Markus, Kielian, Margaret

“…The alphavirus capsid protein (Cp) selectively packages genomic RNA (gRNA) into the viral nucleocapsid to produce infectious virus. Using photoactivatable…”
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Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP by Hafner, Markus, Landthaler, Markus, Burger, Lukas, Khorshid, Mohsen, Hausser, Jean, Berninger, Philipp, Rothballer, Andrea, Ascano, Manuel, Jungkamp, Anna-Carina, Munschauer, Mathias, Ulrich, Alexander, Wardle, Greg S., Dewell, Scott, Zavolan, Mihaela, Tuschl, Thomas

“…RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein…”
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Rapid image deconvolution and multiview fusion for optical microscopy by Guo, Min, Li, Yue, Su, Yijun, Lambert, Talley, Nogare, Damian Dalle, Moyle, Mark W., Duncan, Leighton H., Ikegami, Richard, Santella, Anthony, Rey-Suarez, Ivan, Green, Daniel, Beiriger, Anastasia, Chen, Jiji, Vishwasrao, Harshad, Ganesan, Sundar, Prince, Victoria, Waters, Jennifer C., Annunziata, Christina M., Hafner, Markus, Mohler, William A., Chitnis, Ajay B., Upadhyaya, Arpita, Usdin, Ted B., Bao, Zhirong, Colón-Ramos, Daniel, La Riviere, Patrick, Liu, Huafeng, Wu, Yicong, Shroff, Hari

“…The contrast and resolution of images obtained with optical microscopes can be improved by deconvolution and computational fusion of multiple views of the same…”
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The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation by Palangat, Murali, Anastasakis, Dimitrios G, Fei, Dennis Liang, Lindblad, Katherine E, Bradley, Robert, Hourigan, Christopher S, Hafner, Markus, Larson, Daniel R

“…Somatic mutations in the genes encoding components of the spliceosome occur frequently in human neoplasms, including myeloid dysplasias and leukemias, and less…”
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Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs by Schöller, Eva, Marks, James, Marchand, Virginie, Bruckmann, Astrid, Powell, Christopher A., Reichold, Markus, Mutti, Christian Daniel, Dettmer, Katja, Feederle, Regina, Hüttelmaier, Stefan, Helm, Mark, Oefner, Peter, Minczuk, Michal, Motorin, Yuri, Hafner, Markus, Meister, Gunter

“…Mitochondria contain a specific translation machinery for the synthesis of mitochondria-encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs)…”
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microRNAs are biomarkers of oncogenic human papillomavirus infections by Wang, Xiaohong, Wang, Hsu-Kun, Li, Yang, Hafner, Markus, Banerjee, Nilam Sanjib, Tang, Shuang, Briskin, Daniel, Meyers, Craig, Chow, Louise T., Xie, Xing, Tuschl, Thomas, Zheng, Zhi-Ming

“…Cellular and viral microRNAs (miRNAs) are the transcriptional products of RNA polymerase II and are regulated by transcriptional factors for their differential…”
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Epigenetic repression of antiviral genes by SARS-CoV-2 NSP1 by Anastasakis, Dimitrios G, Benhalevy, Daniel, Çuburu, Nicolas, Altan-Bonnet, Nihal, Hafner, Markus

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the innate immune machinery through multiple viral proteins, including nonstructural…”
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Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response by Lipchina, Inna, Elkabetz, Yechiel, Hafner, Markus, Sheridan, Robert, Mihailovic, Aleksandra, Tuschl, Thomas, Sander, Chris, Studer, Lorenz, Betel, Doron

“…MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency…”
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Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3 by Wang, Saifeng, Chim, Bryan, Su, Yijun, Khil, Pavel, Wong, Madeline, Wang, Xiantao, Foroushani, Amir, Smith, Patrick T, Liu, Xiuhuai, Li, Rui, Ganesan, Sundar, Kanellopoulou, Chrysi, Hafner, Markus, Muljo, Stefan A

“…Fetal hematopoietic stem and progenitor cells (HSPCs) hold promise to cure a wide array of hematological diseases, and we previously found a role for the…”
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The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation by Benhalevy, Daniel, Gupta, Sanjay K., Danan, Charles H., Ghosal, Suman, Sun, Hong-Wei, Kazemier, Hinke G., Paeschke, Katrin, Hafner, Markus, Juranek, Stefan A.

“…The CCHC-type zinc finger nucleic acid-binding protein (CNBP/ZNF9) is conserved in eukaryotes and is essential for embryonic development in mammals. It has…”
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Global target mRNA specification and regulation by the RNA-binding protein ZFP36 by Mukherjee, Neelanjan, Jacobs, Nicholas C, Hafner, Markus, Kennington, Elizabeth A, Nusbaum, Jeffrey D, Tuschl, Thomas, Blackshear, Perry J, Ohler, Uwe

“…ZFP36, also known as tristetraprolin or TTP, and ELAVL1, also known as HuR, are two disease-relevant RNA-binding proteins (RBPs) that both interact with…”
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Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing by Hafner, Markus, Landgraf, Pablo, Ludwig, Janos, Rice, Amanda, Ojo, Tolulope, Lin, Carolina, Holoch, Daniel, Lim, Cindy, Tuschl, Thomas

“…Distinct classes of small RNAs, 20–32 nucleotides long, play important regulatory roles for diverse cellular processes. It is therefore important to identify…”
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Profiling of m6A RNA modifications identified an age‐associated regulation of AGO2 mRNA stability by Min, Kyung‐Won, Zealy, Richard W., Davila, Sylvia, Fomin, Mikhail, Cummings, James C., Makowsky, Daniel, Mcdowell, Catherine H., Thigpen, Haley, Hafner, Markus, Kwon, Sang‐Ho, Georgescu, Constantin, Wren, Jonathan D., Yoon, Je‐Hyun

“…Summary Gene expression is dynamically regulated in a variety of mammalian physiologies. During mammalian aging, there are changes that occur in protein…”
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Absolute quantification of microRNAs by using a universal reference by Bissels, Ute, Wild, Stefan, Tomiuk, Stefan, Holste, Angela, Hafner, Markus, Tuschl, Thomas, Bosio, Andreas

“…MicroRNAs (miRNAs) are a species of small RNAs approximately 21-23-nucleotides long that have been shown to play an important role in many different cellular,…”
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RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries by Hafner, Markus, Renwick, Neil, Brown, Miguel, Mihailović, Aleksandra, Holoch, Daniel, Lin, Carolina, Pena, John T G, Nusbaum, Jeffrey D, Morozov, Pavel, Ludwig, Janos, Ojo, Tolulope, Luo, Shujun, Schroth, Gary, Tuschl, Thomas

“…Sequencing of small RNA cDNA libraries is an important tool for the discovery of new RNAs and the analysis of their mutational status as well as expression…”
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The viral and cellular microRNA targetome in lymphoblastoid cell lines by Skalsky, Rebecca L, Corcoran, David L, Gottwein, Eva, Frank, Christopher L, Kang, Dong, Hafner, Markus, Nusbaum, Jeffrey D, Feederle, Regina, Delecluse, Henri-Jacques, Luftig, Micah A, Tuschl, Thomas, Ohler, Uwe, Cullen, Bryan R

“…Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV…”
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