Search Results - "HAFFNER, Michael"

Divining Harm-Benefit Tradeoffs of Magnetic Resonance Imaging-targeted Biopsy by Etzioni, Ruth, Haffner, Michael C., Gulati, Roman

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Genomic and phenotypic heterogeneity in prostate cancer by Haffner, Michael C., Zwart, Wilbert, Roudier, Martine P., True, Lawrence D., Nelson, William G., Epstein, Jonathan I., De Marzo, Angelo M., Nelson, Peter S., Yegnasubramanian, Srinivasan

“…From a clinical, morphological and molecular perspective, prostate cancer is a heterogeneous disease. Primary prostate cancers are often multifocal, having…”
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Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma by Orr, Brent A, Haffner, Michael C, Nelson, William G, Yegnasubramanian, Srinivasan, Eberhart, Charles G

“…Epigenetic modification of DNA by cytosine methylation to produce 5-methylcytosine (5mC) has become well-recognized as an important epigenetic process in human…”
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Tracking the clonal origin of lethal prostate cancer by Haffner, Michael C, Mosbruger, Timothy, Esopi, David M, Fedor, Helen, Heaphy, Christopher M, Walker, David A, Adejola, Nkosi, Gürel, Meltem, Hicks, Jessica, Meeker, Alan K, Halushka, Marc K, Simons, Jonathan W, Isaacs, William B, De Marzo, Angelo M, Nelson, William G, Yegnasubramanian, Srinivasan

“…Recent controversies surrounding prostate cancer overtreatment emphasize the critical need to delineate the molecular features associated with progression to…”
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Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7 by Yamamoto, Ami, Huang, Yin, Krajina, Brad A, McBirney, Margaux, Doak, Andrea E, Qu, Sixuan, Wang, Carolyn L, Haffner, Michael C, Cheung, Kevin J

“…Necrosis in the tumor interior is a common feature of aggressive cancers that is associated with poor clinical prognosis and the development of metastasis. How…”
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Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy by Bhatia, Vipul, Kamat, Nikhil V., Pariva, Tiffany E., Wu, Li-Ting, Tsao, Annabelle, Sasaki, Koichi, Sun, Huiyun, Javier, Gerardo, Nutt, Sam, Coleman, Ilsa, Hitchcock, Lauren, Zhang, Ailin, Rudoy, Dmytro, Gulati, Roman, Patel, Radhika A., Roudier, Martine P., True, Lawrence D., Srivastava, Shivani, Morrissey, Colm M., Haffner, Michael C., Nelson, Peter S., Priceman, Saul J., Ishihara, Jun, Lee, John K.

“…Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for therapeutic targeting in prostate cancer. Here, we report broad…”
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Molecular Pathology of Prostate Cancer by Kulac, Ibrahim, Roudier, Martine P., Haffner, Michael C.

“…Molecular profiling studies have shed new light on the complex biology of prostate cancer. Genomic studies have highlighted that structural rearrangements are…”
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Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: results from a pilot clinical study by Schweizer, Michael T, Antonarakis, Emmanuel S, Wang, Hao, Ajiboye, A Seun, Spitz, Avery, Cao, Haiyi, Luo, Jun, Haffner, Michael C, Yegnasubramanian, Srinivasan, Carducci, Michael A, Eisenberger, Mario A, Isaacs, John T, Denmeade, Samuel R

“…Targeting androgen receptor (AR) axis signaling by disrupting androgen-AR interactions remains the primary treatment for metastatic prostate cancer…”
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DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases by Aryee, Martin J, Liu, Wennuan, Engelmann, Julia C, Nuhn, Philipp, Gurel, Meltem, Haffner, Michael C, Esopi, David, Irizarry, Rafael A, Getzenberg, Robert H, Nelson, William G, Luo, Jun, Xu, Jianfeng, Isaacs, William B, Bova, G Steven, Yegnasubramanian, Srinivasan

“…Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigenetic marks, including DNA methylation, are potentially…”
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PD-L1 Assays 22C3 and SP263 are Not Interchangeable in Non–Small Cell Lung Cancer When Considering Clinically Relevant Cutoffs: An Interclone Evaluation by Differently Trained Pathologists by Munari, Enrico, Rossi, Giulio, Zamboni, Giuseppe, Lunardi, Gianluigi, Marconi, Marcella, Sommaggio, Marco, Netto, George J, Hoque, Mohammad O, Brunelli, Matteo, Martignoni, Guido, Haffner, Michael C, Moretta, Francesca, Pegoraro, Maria C, Cavazza, Alberto, Samogin, Giuseppina, Furlan, Vanna, Mariotti, Francesca R, Vacca, Paola, Moretta, Lorenzo, Bogina, Giuseppe

“…Pembrolizumab is the only programmed cell death 1/programmed death-ligand 1 inhibitor for treatment of patients with non–small cell lung cancer, with a…”
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Whole Genome Sequencing Reveals Independent Clonal Origin of Bilateral Testicular Germ Cell Tumors in 2 Patients with Pure Seminoma by Biles, Michael J., Haffner, Michael C., Hanratty, Brian, Pierorazio, Phillip M.

“…The pathophysiology of bilateral testicular germ cell tumors (TGCT) is poorly understood. It is unclear if they develop independently, arise from common…”
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Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration-Resistant Prostate Cancer by Coleman, Ilsa M, DeSarkar, Navonil, Morrissey, Colm, Xin, Li, Roudier, Martine P, Sayar, Erolcan, Li, Dapei, Corey, Eva, Haffner, Michael C, Nelson, Peter S

“…To determine whether metastatic castration-resistant prostate cancers (mCRPC) partition into molecular phenotypes corresponding to intrinsic differentiation…”
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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression by Jana, Sujata, Brahma, Sandipan, Arora, Sonali, Wladyka, Cynthia L., Hoang, Patrick, Blinka, Steven, Hough, Rowan, Horn, Jessie L., Liu, Yuzhen, Wang, Li-Jie, Depeille, Philippe, Smith, Eric, Montgomery, Robert B., Lee, John K., Haffner, Michael C., Vakar-Lopez, Funda, Grivas, Petros, Wright, Jonathan L., Lam, Hung-Ming, Black, Peter C., Roose, Jeroen P., Ryazanov, Alexey G., Subramaniam, Arvind R., Henikoff, Steven, Hsieh, Andrew C.

“…We uncover a tumor-suppressive process in urothelium called transcriptional-translational conflict caused by deregulation of the central chromatin remodeling…”
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Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer by Haffner, Michael C., Guner, Gunes, Taheri, Diana, Netto, George J., Palsgrove, Doreen N., Zheng, Qizhi, Guedes, Liana Benevides, Kim, Kunhwa, Tsai, Harrison, Esopi, David M., Lotan, Tamara L., Sharma, Rajni, Meeker, Alan K., Chinnaiyan, Arul M., Nelson, William G., Yegnasubramanian, Srinivasan, Luo, Jun, Mehra, Rohit, Antonarakis, Emmanuel S., Drake, Charles G., De Marzo, Angelo M.

“…Antibodies targeting the programmed cell death protein 1/programmed death-ligand 1 (PD-L1) interaction have shown clinical activity in multiple cancer types…”
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Gleason pattern 4 with cribriform morphology on biopsy is associated with adverse clinicopathological findings in a prospective radical prostatectomy cohort by Haffner, Michael C., Salles, Daniela C., Gao, Guofeng, Epstein, Jonathan I.

“…The prognostic significance of the Gleason grading system has been well established. However, individual Gleason patterns comprise heterogeneous morphologies…”
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Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression by Hughes, Robert M, Simons, Brian W, Khan, Hamda, Miller, Rebecca, Kugler, Valentina, Torquato, Samantha, Theodros, Debebe, Haffner, Michael C, Lotan, Tamara, Huang, Jessie, Davicioni, Elai, An, Steven S, Riddle, Ryan C, Thorek, Daniel L J, Garraway, Isla P, Fertig, Elana J, Isaacs, John T, Brennen, W Nathaniel, Park, Ben H, Hurley, Paula J

“…Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple cell types within the tumor microenvironment. Here…”
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Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements by Nelson, William G, Yegnasubramanian, Srinivasan, Haffner, Michael C, Aryee, Martin J, Toubaji, Antoun, Esopi, David M, Albadine, Roula, Gurel, Bora, Isaacs, William B, Bova, G Steven, Liu, Wennuan, Xu, Jianfeng, Meeker, Alan K, Netto, George, De Marzo, Angelo M

“…Srinivasan Yegnasubramanian and colleagues show that androgen signaling promotes recruitment of androgen receptor and TOP2B to sites of TMPRSS2 - ERG genomic…”
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Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence by Tomasetti, Cristian, Poling, Justin, Roberts, Nicholas J., London, Nyall R., Pittman, Meredith E., Haffner, Michael C., Rizzo, Anthony, Baras, Alex, Karim, Baktiar, Kim, Antonio, Heaphy, Christopher M., Meeker, Alan K., Hruban, Ralph H., Iacobuzio-Donahue, Christine A., Vogelstein, Bert

“…A new evaluation of previously published data suggested to us that the accumulation of mutations might slow, rather than increase, as individuals age. To…”
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Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers by Haffner, Michael C, Chaux, Alcides, Meeker, Alan K, Esopi, David M, Gerber, Jonathan, Pellakuru, Laxmi G, Toubaji, Antoun, Argani, Pedram, Iacobuzio-Donahue, Christine, Nelson, William G, Netto, George J, De Marzo, Angelo M, Yegnasubramanian, Srinivasan

“…DNA methylation at the 5-position of cytosines (5 mC) represents an important epigenetic modification involved in tissue differentiation and is frequently…”
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Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer by DeLucia, Diana C, Cardillo, Thomas M, Ang, Lisa, Labrecque, Mark P, Zhang, Ailin, Hopkins, James E, De Sarkar, Navonil, Coleman, Ilsa, da Costa, Rui M Gil, Corey, Eva, True, Lawrence D, Haffner, Michael C, Schweizer, Michael T, Morrissey, Colm, Nelson, Peter S, Lee, John K

“…Neuroendocrine prostate cancer (NEPC) is an aggressive form of castration-resistant prostate cancer (CRPC) for which effective therapies are lacking. We…”
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