Search Results - "HACKETT, C. J"

Innate immune activation as a broad-spectrum biodefense strategy: Prospects and research challenges by Hackett, Charles J

“…Biodefense strategies require protection against a broad and largely unforeseen spectrum of pathogens—the forte of innate immune system defenses—that have…”
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Class II major histocompatibility complex-restricted T cells specific for a virion structural protein that do not recognize exogenous influenza virus: evidence that presentation of labile T cell determinants is favored by endogenous antigen synthesis by EISENLOHR, L. C, HACKETT, C. J

“…The contribution of viral infectivity to the expression of MHC class II-restricted T cell determinants was studied. A murine I-Ed-restricted T cell hybridoma…”
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Role of receptor-binding activity of the viral hemagglutinin molecule in the presentation of influenza virus antigens to helper T cells by EISENLOHR, L. C, GERHARD, W, HACKETT, C. J

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Immunogenic peptides of influenza virus subtype N1 neuraminidase identify a T-cell determinant used in class II major histocompatibility complex-restricted responses to infectious virus by HACKETT, C. J, HOROWITZ, D, WYSOCKA, M, EISENLOHR, L. C

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Individual class II-restricted antigenic determinants of the same protein exhibit distinct kinetics of appearance and persistence on antigen-presenting cells by Eisenlohr, LC, Gerhard, W, Hackett, CJ

“…The kinetics of presentation of class II-restricted T cell determinants of influenza virus hemagglutinin (HA) was investigated over a 48-h time course after…”
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A synthetic decapeptide of influenza virus hemagglutinin elicits helper T cells with the same fine recognition specificities as occur in response to whole virus by Hackett, CJ, Hurwitz, JL, Dietzschold, B, Gerhard, W

“…The immunogenicity of an isolated murine helper T cell determinant was studied. Mice were immunized with a synthetic peptide corresponding to amino acid…”
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Acid-induced conformational modification of the hemagglutinin molecule alters interaction of influenza virus with antigen-presenting cells by Eisenlohr, LC, Gerhard, W, Hackett, CJ

“…Brief exposure of influenza virus to pH 5 was found to have extensive effects upon presentation of viral Th cell antigenic determinants. This acidity,…”
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Class I H-2d-restricted cytotoxic T lymphocytes recognize the neuraminidase glycoprotein of influenza virus subtype N1 by WYSOCKA, M, HACKETT, C. J

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Microscopical Focal Destruction (Tunnels) in Exhumed Human Bones by Hackett, C.J.

“…This is a survey of microscopical focal destruction in exhumed human bones from several countries and burial times. The single change (destruction) seen in…”
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Influenza virus infection elicits class II major histocompatibility complex-restricted T cells specific for an epitope identified in the NS1 non-structural protein by Hackett, Charles J, Horowitz, Daniel, Wysocka, Maria, Dillon, Susan B

“…The 1 Wistar Institute, Thirty-Sixth Street at Spruce, Philadelphia, Pennsylvania 19104 and 2 SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania…”
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Influenza virus site recognized by a murine helper T cell specific for H1 strains. Localization to a nine amino acid sequence in the hemagglutinin molecule by HACKETT, C. J, DIETZSCHOLD, B, GERHARD, W, GHRIST, B, KNORR, R, GILLESSEN, D, MELCHERS, F

“…The functional helper T cell line Vir-2, derived from a PR8 (H1N1) influenza virus-immunized BALB/c mouse, proliferates in response to syngeneic…”
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Cell-mediated processing and presentation of T cell antigenic determinants by Hackett, C J

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On the epidemiology of yaws in African miners (1942) by Hackett, C J

“…Several points of interest arise from these unusual human yaws infections: (i) European miners contracted a treponemal infection from Africans with yaws and…”
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Influenza-specific suppression: contribution of major viral proteins to the generation and function of T suppressor cells by Hurwitz, JL, Hackett, CJ

“…Suppressor cells were generated in BALB/c mice by two sequential injections of PR8 influenza virus (A/Puerto Rico/8/34[H1N1]) and were tested for their ability…”
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Murine TH response to influenza virus: recognition of hemagglutinin, neuraminidase, matrix, and nucleoproteins by Hurwitz, JL, Hackett, CJ, McAndrew, EC, Gerhard, W

“…BALB/c mice were primed with type A influenza virus by footpad injection or by aerosol infection with PR8 [A/PR/8/34-(H1N1)]. Isolated T cells from draining…”
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Virus entry and antigen biosynthesis in the processing and presentation of class-II MHC-restricted T-cell determinants of influenza virus by Hackett, C J, Eisenlohr, L C

“…Receptor-mediated uptake of influenza virus is responsible for efficient introduction of virus particles to APC. This leads to the effective presentation to…”
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Characterization of epitopes recognized by hapten-specific CD4+ T cells by Cavani, A, Hackett, CJ, Wilson, KJ, Rothbard, JB, Katz, SI

“…Although protein-derived nominal Ags have, in many instances, been precisely determined, the epitopes recognized by hapten-specific CD4+ T cells responsible…”
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An introduction to diagnostic criteria of syphilis, treponarid and yaws (treponematoses) in dry bones, and some implications by Hackett, C J

“…Diagnostic criteria of syphilis and some other diseases are proposed from a study of 424 crania and calvariae and 250 long bones in 22 medical museums in…”
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ON THE ORIGIN OF THE HUMAN TREPONEMATOSES (PINTA, YAWS, ENDEMIC SYPHILIS AND VENEREAL SYPHILIS) by HACKETT, C J

“…A close relationship between the four human treponematoses is suggested by their clinical and epidemiological characteristics and by such limited knowledge of…”
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Private medical practice and anti-yaws campaigns in South Eastern Nigeria 1925-1950 by Hackett, C J

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