Search Results - "HACK, C"

Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement by Estapé Senti, Mariona, de Jongh, Caroline A., Dijkxhoorn, Kim, Verhoef, Johan J.F., Szebeni, Janos, Storm, Gert, Hack, C. Erik, Schiffelers, Raymond M., Fens, Marcel H., Boross, Peter

“…PEGylation of lipid-based nanoparticles and other nanocarriers is widely used to increase their stability and plasma half-life. However, either pre-existing or…”
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Granzymes regulate proinflammatory cytokine responses by Wensink, Annette C, Hack, C Erik, Bovenschen, Niels

“…Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocytes and are traditionally considered to cause apoptosis in tumor cells and virally…”
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CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain by Krukowski, Karen, Eijkelkamp, Niels, Laumet, Geoffroy, Hack, C Erik, Li, Yan, Dougherty, Patrick M, Heijnen, Cobi J, Kavelaars, Annemieke

“…Chemotherapy-induced peripheral neuropathy (CIPN), characterized by pain and numbness in hands and feet, is a common side effect of cancer treatment. In most…”
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Elevated D‐dimers in attacks of hereditary angioedema are not associated with increased thrombotic risk by Reshef, A., Zanichelli, A., Longhurst, H., Relan, A., Hack, C. E.

“…Background Recommended management of attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor (C1‐INH) deficiency (C1‐INH‐HAE) includes therapy with…”
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Bradykinin: Inflammatory Product of the Coagulation System by Hofman, Zonne, de Maat, Steven, Hack, C. Erik, Maas, Coen

“…Episodic and recurrent local cutaneous or mucosal swelling are key features of angioedema. The vasoactive agents histamine and bradykinin are highly implicated…”
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Angioedema attacks in patients with hereditary angioedema: Local manifestations of a systemic activation process by Hofman, Zonne L.M., MD, Relan, Anurag, MD, PhD, Zeerleeder, Sacha, MD, PhD, Drouet, Christian, PhD, Zuraw, Bruce, MD, Hack, C. Erik, MD, PhD

“…Hereditary angioedema (HAE) caused by a deficiency of functional C1-inhibitor (C1INH) becomes clinically manifest as attacks of angioedema. C1INH is the main…”
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Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways by Prado, Judith, Westerink, Remco H. S., Popov-Celeketic, Jelena, Steen-Louws, Cristine, Pandit, Aridaman, Versteeg, Sabine, van de Worp, Wouter, Kanters, Deon H. A. J., Reedquist, Kris A., Koenderman, Leo, Hack, C. Erik, Eijkelkamp, Niels

“…New therapeutic approaches to resolve persistent pain are highly needed. We tested the hypothesis that manipulation of cytokine receptors on sensory neurons by…”
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Serum inflammatory proteins and cognitive decline in older persons by DIK, M. G, JONKER, C, HACK, C. E, SMIT, J. H, COMIJS, H. C, EIKELENBOOM, P

“…To assess whether serum levels of the inflammatory proteins alpha(1)-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are…”
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Recombinant human C1-inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema by Zuraw, Bruce, MD, Cicardi, Marco, MD, Levy, Robyn J., MD, Nuijens, Jan H., MD, PhD, Relan, Anurag, MD, Visscher, Sonja, Haase, Gerald, MD, Kaufman, Leonard, PhD, Hack, C. Erik, MD, PhD

“…Background Hereditary angioedema (HAE) results from a genetic deficiency of C1-inhibitor. Two similar independent, randomized, saline controlled, double-blind…”
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Self-administration of C1-inhibitor concentrate in patients with hereditary or acquired angioedema caused by C1-inhibitor deficiency by Levi, Marcel, Choi, Goda, Picavet, Charles, Hack, C. Erik

“…Administration of C1-inhibitor concentrate is effective for prophylaxis and treatment of severe angioedema attacks caused by C1-inhibitor deficiency. The…”
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Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study by van Helvoort, E M, Popov-Celeketic, J, Eijkelkamp, N, Coeleveld, K, Tryfonidou, M A, Wijne, C D, Hack, C E, Lafeber, F P J G, Mastbergen, S C

“…An ideal disease modifying osteoarthritis drug (DMOAD) has chondroprotective, anti-inflammatory, and analgesic effects. This study describes the production and…”
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A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation by Hofman, Zonne L.M., Clark, Chantal C., Sanrattana, Wariya, Nosairi, Aziz, Parr, Naomi M.J., Živkovic, Minka, Krause, Karoline, Mahnke, Niklas A., Scheffel, Jörg, Hack, C. Erik, Maurer, Marcus, de Maat, Steven, Maas, Coen

“…Coagulation factor XII (FXII) drives production of the inflammatory peptide bradykinin. Pathological mutations in the F12 gene, which encodes FXII, provoke…”
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PBPK model reporting template for chemical risk assessment applications by Tan, Yu-Mei, Chan, Melissa, Chukwudebe, Amechi, Domoradzki, Jeanne, Fisher, Jeffrey, Hack, C. Eric, Hinderliter, Paul, Hirasawa, Kota, Leonard, Jeremy, Lumen, Annie, Paini, Alicia, Qian, Hua, Ruiz, Patricia, Wambaugh, John, Zhang, Fagen, Embry, Michelle

“…Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical…”
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Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond by Agostoni, Angelo, Aygören-Pürsün, Emel, Binkley, Karen E., Blanch, Alvaro, Bork, Konrad, Bouillet, Laurence, Bucher, Christoph, Castaldo, Anthony J, Cicardi, Marco, Davis, Alvin E, De Carolis, Caterina, Drouet, Christian, Duponchel, Christiane, Farkas, Henriette, Fáy, Kálmán, Fekete, Béla, Fischer, Bettina, Fontana, Luigi, Füst, George, Giacomelli, Roberto, Gröner, Albrecht, Erik Hack, C., Harmat, George, Jakenfelds, John, Juers, Mathias, Kalmár, Lajos, Kaposi, Pál N., Karádi, István, Kitzinger, Arianna, Kollár, Tímea, Kreuz, Wolfhart, Lakatos, Peter, Longhurst, Hilary J., Lopez-Trascasa, Margarita, Martinez-Saguer, Inmaculada, Monnier, Nicole, Nagy, István, Németh, Éva, Nielsen, Erik Waage, Nuijens, Jan H., O'Grady, Caroline, Pappalardo, Emanuela, Penna, Vincenzo, Perricone, Carlo, Perricone, Roberto, Rauch, Ursula, Roche, Olga, Rusicke, Eva, Späth, Peter J, Szendei, George, Takács, Edit, Tordai, Attila, Truedsson, Lennart, Varga, Lilian, Visy, Beáta, Williams, Kayla, Zanichelli, Andrea, Zingale, Lorenza

“…Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or peripheral swelling or…”
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The endothelium in sepsis: Source of and a target for inflammation by Hack, C Erik, Zeerleder, Sacha

“…OBJECTIVETo discuss a possible role of the endothelium in sepsis. DATA SOURCESStudies published in biomedical journals and our own experimental results. STUDY…”
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Disseminated intravascular coagulation in sepsis by Zeerleder, Sacha, Hack, C Erik, Wuillemin, Walter A

“…Disseminated intravascular coagulation is a frequent complication of sepsis. Coagulation activation, inhibition of fibrinolysis, and consumption of coagulation…”
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Target levels of functional C1-inhibitor in hereditary angioedema by Hack, C. E., Relan, A., van Amersfoort, E. S., Cicardi, M.

“…To cite this article: Hack CE, Relan A, van Amersfoort ES, Cicardi M. Target levels of functional C1‐inhibitor in hereditary angioedema. Allergy 2012; 67:…”
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The contributions of breast density and common genetic variation to breast cancer risk by Vachon, Celine M, Pankratz, V Shane, Scott, Christopher G, Haeberle, Lothar, Ziv, Elad, Jensen, Matthew R, Brandt, Kathleen R, Whaley, Dana H, Olson, Janet E, Heusinger, Katharina, Hack, Carolin C, Jud, Sebastian M, Beckmann, Matthias W, Schulz-Wendtland, Ruediger, Tice, Jeffrey A, Norman, Aaron D, Cunningham, Julie M, Purrington, Kristen S, Easton, Douglas F, Sellers, Thomas A, Kerlikowske, Karla, Fasching, Peter A, Couch, Fergus J

“…We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting and Data System (BI-RADS) breast density were independent risk factors…”
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Serine proteases of the human immune system in health and disease by Heutinck, Kirstin M., ten Berge, Ineke J.M., Hack, C. Erik, Hamann, Jörg, Rowshani, Ajda T.

“…Serine proteases form a large family of protein-cleaving enzymes that play an essential role in processes like blood coagulation, apoptosis and inflammation…”
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Detecting oral kallikrein-targeting therapy through triggered contact activation: A phase I study by Hofman, Zonne L.M., Clark, Chantal C., Hack, C. Erik, de Maat, Steven, Maas, Coen

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