Search Results - "HACHIYA, Akira"

Autophagy Has a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes by Murase, Daiki, Hachiya, Akira, Takano, Kei, Hicks, Rachel, Visscher, Marty O., Kitahara, Takashi, Hase, Tadashi, Takema, Yoshinori, Yoshimori, Tamotsu

“…Melanin in the epidermis determines the wide variation in skin color associated with ethnic skin diversity. Ethnic differences exist regarding melanosome loss…”
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Autophagy Declines with Premature Skin Aging resulting in Dynamic Alterations in Skin Pigmentation and Epidermal Differentiation by Murase, Daiki, Kusaka-Kikushima, Ayumi, Hachiya, Akira, Fullenkamp, Rachel, Stepp, Anita, Imai, Asuka, Ueno, Mizuki, Kawabata, Keigo, Takahashi, Yoshito, Hase, Tadashi, Ohuchi, Atsushi, Nakamura, Shuhei, Yoshimori, Tamotsu

“…Autophagy is a membrane traffic system that provides sustainable degradation of cellular components for homeostasis, and is thus considered to promote health…”
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Myocardial ischemia during methylprednisolone pulse therapy with dipyridamole by Tsukahara, Takanori, Matsuoka, Daisuke, Shimada, Shun, Hachiya, Akira, Motoki, Noriko

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Prognostic Significance of QT Interval Dispersion in the Response to Intravenous Immunoglobulin Therapy in Kawasaki Disease by Motoki, Noriko, Akazawa, Yohei, Yamazaki, Shoko, Hachiya, Akira, Motoki, Hirohiko, Matsuzaki, Satoshi, Koike, Kenichi

“…Background:Kawasaki disease (KD) is classified as a systemic vasculitis syndrome and QT interval dispersion (QTD) has been associated with cardiac involvement…”
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Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants　– Implications for Fetal Programming by Akazawa, Yohei, Hachiya, Akira, Yamazaki, Shoko, Kawasaki, Yoichiro, Nakamura, Chizuko, Takeuchi, Yusuke, Kusakari, Mai, Miyosawa, Yukihide, Kamiya, Motoko, Motoki, Noriko, Koike, Kenichi, Nakamura, Tomohiko

“…Background:The purpose of this study was to clarify cardiovascular structure and function in small for gestational age (SGA) infants across a range of…”
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Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold by Kasamatsu, Shinya, Hachiya, Akira, Nakamura, Shun, Yasuda, Yuka, Fujimori, Taketoshi, Takano, Kei, Moriwaki, Shigeru, Hase, Tadashi, Suzuki, Tamio, Matsunaga, Kayoko

“…Highlights • We investigate the causes of unexpected depigmentation induced by rhododendrol. • Melanocyte damage is related to tyrosinase activity at a certain…”
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Decreased Aortic Elasticity in Children With Marfan Syndrome or Loeys-Dietz Syndrome by Akazawa, Yohei, Motoki, Noriko, Tada, Akira, Yamazaki, Shoko, Hachiya, Akira, Matsuzaki, Satoshi, Kamiya, Motoko, Nakamura, Tomohiko, Kosho, Tomoki, Inaba, Yuji

“…Background:The characteristics of aortic elasticity are unclear in children with connective tissue disorders (CTDs) such as Marfan syndrome (MFS) and…”
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Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma by Gabe, Yu, Miyaji, Akimitsu, Kohno, Masahiro, Hachiya, Akira, Moriwaki, Shigeru, Baba, Toshihide

“…•Elaborate hydroxyl radical detection after rhododendrol application to melanocytes.•Remarkable correlation of hydroxyl radical generation with melanocyte…”
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Quantitative changes in the secretion of exosomes from keratinocytes homeostatically regulate skin pigmentation in a paracrine manner by Takano, Kei, Hachiya, Akira, Murase, Daiki, Tanabe, Hiroki, Kasamatsu, Shinya, Takahashi, Yoshito, Moriwaki, Shigeru, Hase, Tadashi

“…The content and distribution of melanin in the epidermis determines the wide variety of skin colors associated with ethnic/racial diversity. Although it was…”
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Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol by Kondo, Masatoshi, Kawabata, Keigo, Sato, Kohji, Yamaguchi, Sayuri, Hachiya, Akira, Takahashi, Yoshito, Inoue, Shintaro

“…Summary Rhododendrol is a phenolic compound that shows a tyrosinase‐dependent toxicity for melanocytes and occasionally induces a vitiligo‐like skin…”
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Impact of infliximab administration before plasma exchange therapy on patients with Kawasaki disease by Shimada, Shun, Matsuoka, Daisuke, Murase, Tsubasa, Hachiya, Akira, Motoki, Noriko, Nakazawa, Yozo

“…Plasma exchange is a therapeutic option in refractory Kawasaki disease (KD). However, the effects of other immunosuppressive treatments on plasma exchange…”
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Variation in Hsp70-1A Expression Contributes to Skin Color Diversity by Murase, Daiki, Hachiya, Akira, Fullenkamp, Rachel, Beck, Anita, Moriwaki, Shigeru, Hase, Tadashi, Takema, Yoshinori, Manga, Prashiela

“…The wide range in human skin color results from varying levels of the pigment melanin. Genetic mechanisms underlying coloration differences have been explored,…”
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The Essential Role of p53 in Hyperpigmentation of the Skin via Regulation of Paracrine Melanogenic Cytokine Receptor Signaling by Murase, Daiki, Hachiya, Akira, Amano, Yasuko, Ohuchi, Atsushi, Kitahara, Takashi, Takema, Yoshinori

“…Hyperpigmentation of the skin is characterized by increases in melanin synthesis and deposition. Although considered a significant psychosocial distress,…”
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Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids by Inoue, Takayoshi, Kuwano, Tetsuya, Uehara, Yuya, Yano, Michiko, Oya, Naoki, Takada, Naoto, Tanaka, Shodai, Ueda, Yui, Hachiya, Akira, Takahashi, Yoshito, Ota, Noriyasu, Murase, Takatoshi

“…Non-invasive acquisition of mRNA data from the skin can be extremely useful for understanding skin physiology and diseases. Inspired by the holocrine process,…”
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Expression of steroidogenic enzymes in human sebaceous glands by Inoue, Takayoshi, Miki, Yasuhiro, Kakuo, Shingo, Hachiya, Akira, Kitahara, Takashi, Aiba, Setsuya, Zouboulis, Christos C, Sasano, Hironobu

“…Androgens are well known to influence sebum synthesis and secretion. Various factors related to androgen biosynthesis are expressed in human sebaceous glands…”
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The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach by Takano, Kei, Hachiya, Akira, Murase, Daiki, Kawasaki, Akiko, Uda, Hirokazu, Kasamatsu, Shinya, Sugai, Yoshiya, Takahashi, Yoshito, Hase, Tadashi, Ohuchi, Atsushi, Suzuki, Tamio

“…Melanin in the epidermis is known to ultimately regulate human skin pigmentation. Recently, we exploited a phenotypic-based screening system composed of ex…”
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Sex steroid synthesis in human skin in situ: The roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin by Inoue, Takayoshi, Miki, Yasuhiro, Abe, Keiko, Hatori, Masahito, Hosaka, Masami, Kariya, Yoshiyuki, Kakuo, Shingo, Fujimura, Tsutomu, Hachiya, Akira, Honma, Seijiro, Aiba, Setsuya, Sasano, Hironobu

“…► Sex steroids are well known to affect various skin functions. ► We examined the local biosyntheses of sex steroids in human skin. ► Aromatase plays important…”
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Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection by Kasamatsu, Shinya, Hachiya, Akira, Fujimura, Tsutomu, Sriwiriyanont, Penkanok, Haketa, Keiichi, Visscher, Marty O., Kitzmiller, William J., Bello, Alexander, Kitahara, Takashi, Kobinger, Gary P., Takema, Yoshinori

“…UVB-induced cutaneous photodamage/photoaging is characterized by qualitative and quantitative deterioration in dermal extracellular matrix (ECM) components…”
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The Endogenous Protease Inhibitor TIMP-1 Mediates Protection and Recovery from Cutaneous Photodamage by Yokose, Urara, Hachiya, Akira, Sriwiriyanont, Penkanok, Fujimura, Tsutomu, Visscher, Marty O., Kitzmiller, William J., Bello, Alexander, Tsuboi, Ryoji, Kitahara, Takashi, Kobinger, Gary P., Takema, Yoshinori

“…UVB exposure is well known to induce skin photodamage and photoaging that correlates with qualitative and quantitative deterioration of the dermal…”
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Biphasic Expression of Two Paracrine Melanogenic Cytokines, Stem Cell Factor and Endothelin-1, in Ultraviolet B-Induced Human Melanogenesis by Hachiya, Akira, Kobayashi, Akemi, Yoshida, Yasuko, Kitahara, Takashi, Takema, Yoshinori, Imokawa, Genji

“…Stem cell factor (SCF) and endothelin-1 (ET-1) have been reported to be up-regulated at the protein and gene levels in human epidermis after ultraviolet B…”
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