Search Results - "HAAG, J. D"

On the Utility of Pooling Biological Samples in Microarray Experiments by Kendziorski, C., Irizarry, R. A., K.-S. Chen, Haag, J. D., Gould, M. N., Wahba, Grace

“…Over 15% of the data sets catalogued in the Gene Expression Omnibus Database involve RNA samples that have been pooled before hybridization. Pooling affects…”
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Characterizing a rat Brca2 knockout model by COTRONEO, M. S, HAAG, J. D, DUBIELZIG, R. R, GOULD, M. N, ZAN, Y, LOPEZ, C. C, THUWAJIT, P, PETUKHOVA, G. V, CAMERINI-OTERO, R. D, GENDRON -FITZPATRICK, A, GRIEP, A. E, MURPHY, C. J

“…Evidence exists that BRCA2 carriers may have an elevated risk of breast, ovarian, colon, prostate, and pancreatic cancer. In general, carriers are defined as…”
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The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance by COTRONEO, M. S, MERRY, G. M, HAAG, J. D, LAN, H, SHEPEL, L. A, GOULD, M. N

“…Identification of high-penetrance breast cancer genes such as Brca1 has been accomplished by analysing familial cases. However, these genes occur at low…”
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Activation of the transforming growth factor β signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol by ARIAZI, E. A, SATOMI, Y, ELLIS, M. J, HAAG, J. D, WENGE SHI, SATTLER, C. A, GOULD, M. N

“…The mechanisms of action of the anticancer agent perillyl alcohol (POH), presently in Phase II clinical trials, were investigated in advanced rat mammary…”
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Limonene-induced regression of mammary carcinomas by HAAG, J. D, LINDSTROM, M. J, GOULD, M. N

“…Dietary administration of the monocyclic monoterpenoid d-limonene causes complete regression of both dimethylbenz[alpha]anthracene- and…”
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On the statistical analysis of allelic-loss data by Newton, Michael A., Gould, Michael N., Reznikoff, Catherine A., Haag, Jill D.

“…This paper concerns the statistical analysis of certain binary data arising in molecular studies of cancer. In allelic‐loss experiments, tumour cell genomes…”
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Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene by Crowell, P L, Kennan, W S, Haag, J D, Ahmad, S, Vedejs, E, Gould, M N

“…The monoterpene d-limonene has been shown to an effective, non-toxic chemopreventive agent in mammary and other rodent tumor models. The studies reported here…”
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A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors by Gould, MN, Haag, JD, Kennan, WS, Tanner, MA, Elson, CE

“…Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary…”
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Heterogeneous expression of the lipocalin NGAL in primary breast cancers by Stoesz, Steven P., Friedl, Andreas, Haag, Jill D., Lindstrom, Mary J., Clark, Gary M., Gould, Michael N.

“…We have previously shown that neu oncogene‐initiated rat mammary carcinomas uniquely over‐express neu‐related lipocalin (NRL), a member of the calycin protein…”
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Human metabolism of the experimental cancer therapeutic agent d-limonene by CROWELL, P. L, ELSON, C. E, BAILEY, H. H, ELEGBEDE, A, HAAG, J. D, GOULD, M. N

“…d-Limonene has efficacy in preclinical models of breast cancer, causing > 80% of carcinomas to regress with little host toxicity. We performed a pilot study on…”
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Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras by GOULD, M. N, MOORE, C. J, RONG ZHANG, BINGCHENG WANG, KENNAN, W. S, HAAG, J. D

“…Monoterpenes, including limonene and its in vivo rat plasma metabolites, have been shown to be inhibitors of protein isoprenylation of small G proteins,…”
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Cloning, genetic mapping and expression studies of the rat Brca1 gene by CHEN, K.-S, SHEPEL, L. A, HAAG, J. D, HEIL, G. M, GOULD, M. N

“…The breast cancer gene BRCA1 has previously been cloned from both human and mouse. We cloned a fragment of the rat Brca1 homologue in order to map it and…”
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Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels by ZHANG, R, HAAG, J. D, GOULD, M. N

“…The role of c-Ha-ras-1 oncogene activation in the multistage biological process of N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis was…”
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Genetic linkage mapping of 11 novel DNA markers and the ceruloplasmin (Cp) gene on rat chromosome 2 by Shepel, L A, Fleming, R E, Haag, J D, Brasic, G M, Gheen, M E, Simon, J S, Gould, M N

“…We have mapped 11 novel, anonymous genetic markers to rat chromosome 2. The rat ceruloplasmin gene (Cp) had been previously mapped to chromosomes 2 and…”
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Mammary carcinoma suppressor and susceptibility genes in the Wistar-Kyoto rat by Haag, J D, Newton, M A, Gould, M N

“…The Copenhagen (Cop) rat carries a homozygous mammary carcinoma suppressor (MCS) gene that prevents both spontaneous and induced mammary cancer. Here we…”
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Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene by Haag, J D, Gould, M N

“…The monoterpene perillyl alcohol has been shown to induce the regression of 81% of small mammary carcinomas and up to 75% of advanced mammary carcinomas…”
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Mammary glands of sexually immature rats are more susceptible than those of mature rats to the carcinogenic, lethal, and mutagenic effects of N-nitroso-N-methylurea by Ariazi, Jennifer L., Haag, Jill D., Lindstrom, Mary J., Gould, Michael N.

“…Knowing that the prepubertal period is a time of enhanced susceptibility for radiation‐induced human breast cancer, we used the Fischer 344 rat model to…”
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Site of expression and biological function of the rat mammary carcinoma suppressor gene by Zhang, R, Haag, J D, Gould, M N

“…The rat mammary carcinoma suppressor (MCS) gene is an autosomal dominant gene found in the Copenhagen (Cop) rat that specifically prevents carcinogen-induced…”
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ApcMin, A Mutation in the Murine Apc Gene, Predisposes to Mammary Carcinomas and Focal Alveolar Hyperplasias by MOSER, R, MATTES, E. M, DOVE, W. F, LINDSTROM, M. J, HAAG, J. D, GOULD, M. N

“…ApcMin(Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do…”
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Genetic Loci Controlling Breast Cancer Susceptibility in the Wistar-Kyoto Rat by Lan, Hong, Kendziorski, Christina M, Haag, Jill D, Shepel, Laurie A, Newton, Michael A, Gould, Michael N

“…In this study, the Wistar-Kyoto (WKy) rat was genetically characterized for loci that modify susceptibility to mammary carcinogenesis. We used a genetic…”
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