Search Results - "HA, H. R"

Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues by Waldhauser, K M, Brecht, K, Hebeisen, S, Ha, H R, Konrad, D, Bur, D, Krähenbühl, S

“…Background and purpose: Amiodarone (2‐n‐butyl‐3‐[3,5 diiodo‐4‐diethylaminoethoxybenzoyl]‐benzofuran, B2‐O‐CH2CH2‐N‐diethyl) is an effective class III…”
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Amiodarone Inhibits Arterial Thrombus Formation and Tissue Factor Translation by Breitenstein, A, Stämpfli, S F, Camici, G G, Akhmedov, A, Ha, H R, Follath, F, Bogdanova, A, Lüscher, T F, Tanner, F C

“…BACKGROUND—In patients with coronary artery disease and reduced ejection fraction, amiodarone reduces mortality by decreasing sudden death. Because the latter…”
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Structure-effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination by HA, H. R, STIEGER, B, GRASSI, G, ALTORFER, H. R, FOLLATH, F

“…Amiodarone (AMI) has proven to be a potent anti-arrhythmic compound. Due to the structural similarity between AMI and thyroid hormone, it is possible that the…”
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Prolonged sedation due to accumulation of conjugated metabolites of midazolam by Bauer, T M, Ritz, R, Haberthür, C, Ha, H R, Hunkeler, W, Sleight, A J, Scollo-Lavizzari, G, Haefeli, W E

“…Midazolam is a short-acting benzodiazepine routinely used in intensive-care medicine. Conjugates of its main metabolite, alpha-hydroxymidazolam, have been…”
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Metabolism of theophylline by cDNA‐expressed human cytochromes P‐450 by Ha, HR, Chen, J, Freiburghaus, AU, Follath, F

“…1. Theophylline metabolism was studied using seven human cytochrome P‐ 450 isoforms (CYPs), namely CYP1A1, 1A2, 2A6, 2B6, 2D6, 2E1 and 3A4, and microsomal…”
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Biotransformation of caffeine by cDNA-expressed human cytochromes P-450 by HA, H. R, CHEN, J, KRÄHENBÜHL, S, FOLLATH, F

“…The biotransformation of caffeine has been studied in vitro using human cytochrome P-450 isoenzymes (CYPs) expressed in human B-lymphoblastoid cell lines,…”
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Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone by Kozlik, P., Ha, H. R., Stieger, B., Bigler, L., Follath, F.

“…1. Amiodarone (AMI) is a potent anti-arrhythmic drug and mono-N-desethylamiodarone (MDEA) is its only known metabolite. It was found recently that in rabbit…”
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Myocardial amiodarone concentrations after short- and long-term treatment in patients with end-stage heart failure by CANDINAS, R, FRIELINGSDORF, J, HA, H. R, CARREL, T, TURINA, M, FOLLATH, F

“…Pharmacokinetics and tissue concentrations of amiodarone may vary considerably in end-stage heart failure, but may be crucial for treatment efficiency and…”
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Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease  - and  -Secretase via Distinct Mechanisms by Mitterreiter, S., Page, R. M., Kamp, F., Hopson, J., Winkler, E., Ha, H.-R., Hamid, R., Herms, J., Mayer, T. U., Nelson, D. J., Steiner, H., Stahl, T., Zeitschel, U., Rossner, S., Haass, C., Lichtenthaler, S. F.

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Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria by Spaniol, Markus, Bracher, Roswitha, Ha, Hui Riem, Follath, Ferenc, Krähenbühl, Stephan

“…Background : Amiodarone is a well-known mitochondrial toxin consisting of a benzofuran ring (ring A) coupled to a p-OH-benzene structure substituted with 2…”
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Nonlinear kinetics of propafenone metabolites in healthy man by VOZEH, S, HAEFELI, W, HA, H.-R, VLCEK, J, FOLLATH, F

“…The pharmacokinetics of oral and i.v. propafenone and its major metabolites have been investigated in 8 healthy subjects. The total body clearance of…”
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In vitro inhibition of midazolam and quinidine metabolism by flavonoids by Ha, H R, Chen, J, Leuenberger, P M, Freiburghaus, A U, Follath, F

“…Studies in humans in vivo have demonstrated that substances found in grapefruit juice may increase the bioavailability of dihydropyridine derivatives as a…”
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Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man by Kupferschmidt, Hugo H. T., Fattinger, Karin E., Ha, Huy Riem, Follath, Ferenc, Krähenbühl, Stephan

“…Aims  Saquinavir is a potent HIV protease inhibitor whose effectiveness is limited in vivo by its low bioavailability. Since saquinavir is metabolized by…”
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Are there stereoselective electrophysiologic effects of intravenously administered (S)- or (R)-propafenone hydrochloride in patients with supraventricular tachycardia ? by CANDINAS, R, GLOOR, H. O, LINDNER, W, HA, H. R, BUCHINGER, W, AMANN, F. W, FOLLATH, F

“…The electrophysiological effects of intravenously administered pure (S)- and (R)-propafenone hydrochloride has been determined for the first time in humans-12…”
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Chronic verapamil administration lowers portal pressure and improves hepatic function in rats with liver cirrhosis by Reichen, J, Hirlinger, A, Ha, H R, Sägesser, S

“…The effects of verapamil on portal pressure, microsomal liver function and extravascular albumin space were investigated in rats rendered cirrhotic by chronic…”
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Interaction Between Amiodarone and Lidocaine by Ha, Huy Riem, Candinas, Reto, Stieger, Bruno, Meyer, Urs A, Follath, Ferenc

“…SUMMARYWe investigated the in vitro and in vivo interaction between amiodarone and lidocaine. The interaction on a molecular level was first studied in…”
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Midazolam in plasma from hospitalized patients as measured by gas-liquid chromatography with electron-capture detection by Ha, H R, Funk, B, Maitre, P O, Zbinden, A M, Follath, F, Thomson, D A

“…The present assay was developed for quantifying midazolam in plasma of patients hospitalized in intensive-care units or undergoing anesthesia and receiving…”
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Interaction between grapefruit juice and midazolam in humans by Kupferschmidt, H H, Ha, H R, Ziegler, W H, Meier, P J, Krähenbühl, S

“…To investigate the effects of grapefruit juice on the pharmacokinetics and dynamics of midazolam. Eight healthy male subjects participated in this open…”
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Evaluation of a rapid ultrafiltration technique for determination of quinidine protein binding and comparison with equilibrium dialysis by Ha, H R, Vozeh, S, Follath, F

“…The free level ultrafiltration (UF) assay by the enzyme multiplied immunoassay technique (EMIT) for determination of unbound quinidine concentration in serum…”
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Pharmacokinetics of midazolam in patients recovering from cardiac surgery by Maitre, P O, Funk, B, Crevoisier, C, Ha, H R

“…The pharmacokinetics of midazolam has been studied in patients recovering from cardiac surgery, who required sedation for postoperative mechanical ventilation…”
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